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Record number: 1, Textual support number: 1 CONT

The DNA-binding domains appear to have well-defined structural motifs: by contrast, mutational studies of the activator domains suggest a disquieting picture of a conformationally ill-defined polypeptide that can function almost irrespective of sequence, provided only that there is a sufficient excess of acidic residues clustered or peppered about. Thus, the elegant molecular machinery that so reliably controls expression of eukaryotic polymerase II-transcribed genes relies on nearly shapeless molecular components dubbed "acid blobs" or perhaps more aptly "negative noodles".  1, fiche 1, Anglais, - acid%20blob

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