TERMIUM Plus^®

Fiche 1,  Justifications,  Anglais

Record number: 1, Textual support number: 1 DEF

A recombinant form of Human Interferon Beta made by Triton Biosciences designed to treat HIV infection and Kaposi's Sarcoma. It is classified as : antineoplastic, antiviral, immunomodulator, antiretroviral.  1, fiche 1, Anglais, - interferon%20beta%2D1b

Record number: 1, Textual support number: 1 CONT

BETASERON : Berlex Canada, interferon beta-1b is an immunomodulator used in ambulatory patients with relapsing-remitting multiple sclerosis. Betaseron is a highly purified, sterile, lyophilized protein product produced by recombinant DNA techniques and formulated for use by injection. It is manufactured by bacterial fermentation of a strain of E. coli that bears a genetically engineered plasmid containing the gene for human interferon betaser17. The native gene was obtained from human fibroblasts and altered in a way that substitutes serine for the cysteine residue found at position 17.  1, fiche 1, Anglais, - interferon%20beta%2D1b

Fiche 1,  Justifications,  Français

Fiche 1,  Justifications,  Espagnol

Fiche 2,  Justifications,  Anglais

Record number: 2, Textual support number: 1 DEF

The variety of interferon that is produced by sensitized T lymphocytes on stimulation by specific antigens.  1, fiche 2, Anglais, - gamma%20interferon

Record number: 2, Textual support number: 1 OBS

Besides its action in preventing viral replication, it is a macrophage-activating factor. It is structurally quite distinct from the classical interferons(alpha interferon and Beta interferon).  1, fiche 2, Anglais, - gamma%20interferon

Fiche 2,  Justifications,  Français

Record number: 2, Textual support number: 1 DEF

Cytokine produite par les lymphocytes T, et les cellules NK et qui induit l'expression des molécules de classe II du CMH, la différenciation des monocytes en macrophages et l'activation de leurs différentes propriétés.  1, fiche 2, Français, - interf%C3%A9ron%20gamma

Fiche 2,  Justifications,  Espagnol

Record number: 2, Textual support number: 1 OBS

Secretado por células T [como] reacción ante un antígeno, suprime la reproducción viral y actúa como linfocina, estimulando a los monocitos, macrófagos y otras células del sistema inmune.  1, fiche 2, Espagnol, - interfer%C3%B3n%20gamma

Fiche 3,  Justifications,  Anglais

Record number: 3, Textual support number: 1 CONT

Interferons are a family of naturally occurring small proteins that are produced and secreted by cells in response to viral infection. Alpha and beta interferons are classified type 1 interferons and include more than 25 different molecules. Consensus interferon(CIFN) is a novel, recombinant type 1 interferon containing 166 amino acids. CIFN was derived by scanning the sequences of natural alpha interferons and assigning the most frequently observed amino acid in each corresponding position. CIFN, when compared on an equal mass basis with interferon(IFN) alfa-2 and alpha-2b in in vitro assays, typically displays 5-10 tiems higher biological activity.  1, fiche 3, Anglais, - Consensus%20Interferon

Fiche 3,  Justifications,  Français

Record number: 3, Textual support number: 1 CONT

Par analogie avec la séquence consensus, courte séquence nucléotidique, d'ADN ou d'ARN, impliqué dans un mécanisme commun de signalisation et qui (voir kapbi 1993 pour la suite)  1, fiche 3, Français, - interf%C3%A9ron%20consensus

Fiche 3,  Justifications,  Espagnol

Fiche 4,  Justifications,  Anglais

Record number: 4, Textual support number: 1 CONT

Alpha and beta interferons play an important role in the regulation of the normal immune response. The abnormal production of type I interferons can, however, lead to an inappropriate immune response and to the development of autoimmunity and to the rejection of allografts. The cloning of the type I interferon receptor in our laboratory has enabled us to synthesise soluble variants of the receptor and to isolate a monoclonal antibody capable of inhibiting the biologic action of all the type I interferons tested. We have shown that treatment of monkeys with the anti-interferon receptor antibody together with a subeffective dose of cyclosporin A results in permanent survival of skin and bone marrow allografts.  1, fiche 4, Anglais, - anti%2Dinterferon

Fiche 4,  Justifications,  Français

Record number: 4, Textual support number: 1 CONT

Les immunomodulateurs agissent soit en bloquant les lymphocytes qui franchissent la barrière sang-cerveau (le copolymère, bien toléré, mais qui n'est pas encore autorisé en Europe) soit en s'opposant à l'action de certaines molécules destructives de la myéline (l'interféron ß). Ils réduisent la fréquence des poussées d'environ 30%; l'interféron ß semble, en outre, retarder l'apparition du handicap. En revanche, ce dernier présente des effets secondaires (fatigue, maux de tête, fièvre), qui disparaissent toutefois au bout de quelques semaines. Autre inconvénient, environ 20% des patients développent des anticorps anti-interféron ß.  2, fiche 4, Français, - anti%2Dinterf%C3%A9ron

Fiche 4,  Justifications,  Espagnol