TERMIUM Plus^®

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Researchers first evaluate experimental vaccines in the laboratory and animal models. If a vaccine candidate is safe and appears promising in these preclinical experiments, it may go on to be carefully tested in people. Experimental vaccines undergo several phases of clinical testing to establish their safety and efficacy.  3, fiche 1, Anglais, - experimental%20vaccine

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Dans une première partie, le candidat-vaccin serait essayé sur quelques volontaires qui n'ont guère de risque de rencontrer le virus et sur lesquels il s'agirait simplement de vérifier si la vaccination provoque une montée d'anticorps.  4, fiche 1, Français, - vaccin%20exp%C3%A9rimental

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As well, we are continuing to explore a new approach to subunit vaccine design introduced by our laboratory a number of years ago(see Carayanniotis and Barber(1987) Nature 327, 59). By conjugation of purified protein or synthetic peptide antigens to monoclonal antibodies specific for defined cell surface determinants in vivo(e. g. class II MHC), it is possible to induce an effective antibody response to the "targeted" antigen(for recent data see Skea and Barber(1993) J. Immunol. 151, 3557). We are currently using recombinant DNA approaches to "engineer" specific B-and T-cell epitopes into selected sites on immunotargeting antibodies. In addition to our work using influenza virus as a model, we are also studying conserved B-and T-cell epitopes from HIV in order to develop a candidate AIDS vaccine.  2, fiche 2, Anglais, - immunotargeting

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