TERMIUM Plus^®

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Pooling—sometimes referred to as pool testing or pooled testing—means combining respiratory samples from several people and conducting one laboratory test on the combined pool of samples to detect SARS-CoV-2 [severe acute respiratory syndrome coronavirus 2], the virus that causes COVID-19.  2, fiche 1, Anglais, - pooled%20testing

Fiche 1,  Justifications,  Français

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Analyse biologique qui est effectuée sur un ensemble de prélèvements réalisés au sein d'une population et préalablement mélangés, pour y rechercher la présence d'un marqueur.  1, fiche 1, Français, - test%20group%C3%A9%20sur%20%C3%A9chantillons%20m%C3%A9lang%C3%A9s

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test groupé sur échantillons mélangés; test groupé : désignations et définition publiées au Journal officiel de la République française le 7 août 2022.  4, fiche 1, Français, - test%20group%C3%A9%20sur%20%C3%A9chantillons%20m%C3%A9lang%C3%A9s

Fiche 1,  Justifications,  Espagnol

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La técnica estadística conocida como prueba de grupo [...] puede contribuir al ahorro de recursos cuantiosos para la estimación y detección de enfermedades infecciosas en ciencia animal cuando la prevalencia es menor o igual al 10%.  1, fiche 1, Espagnol, - prueba%20de%20grupo

Fiche 2,  Justifications,  Anglais

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"Gain of function" is a general term.... it is used to describe a change to the genome of any biological entity – a living organism such as an animal, insect, plant, virus, bacterium or fungus – through any process so that it acquires a new or enhanced function. Changes to the genome may occur spontaneously in nature or as the result of an experimental manipulation in a laboratory.  3, fiche 2, Anglais, - gain%20of%20function

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Un gain de fonction est obtenu par la modification du génome d'un organisme ou d'un microorganisme. Cette modification peut survenir spontanément ou résulter d'une manipulation en laboratoire.  2, fiche 2, Français, - gain%20de%20fonction

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Fiche 3,  Justifications,  Anglais

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A document certifying that a person is considered immune against a specific infectious disease.  1, fiche 3, Anglais, - immunity%20certificate

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Immunity passports could be implemented on the basis of either a laboratory test of immune response(a correlate of protection) or an immunising event(infection or vaccination), which would identify individuals less likely to get disease or transmit virus when exposed to SARS-CoV-2.  3, fiche 3, Anglais, - immunity%20certificate

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A vaccine passport is a type of immunity passport.  4, fiche 3, Anglais, - immunity%20certificate

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Document qui atteste qu'une personne est considérée comme immunisée contre une maladie infectieuse donnée.  2, fiche 3, Français, - certificat%20d%27immunit%C3%A9

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[L'Estonie] a développé une application dite «passeport immunitaire», permettant aux personnes ayant développé des anticorps de témoigner, par exemple auprès des employeurs, du risque réduit de propager le coronavirus.  5, fiche 3, Français, - certificat%20d%27immunit%C3%A9

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Un passeport vaccinal est un type de passeport immunitaire.  6, fiche 3, Français, - certificat%20d%27immunit%C3%A9

Fiche 3,  Justifications,  Espagnol

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La Organización Mundial de la Salud (OMS) ha puesto en tela de juicio la eficacia del llamado pasaporte inmunitario, un certificado que identifica a quién ha pasado la enfermedad y estaría libre de volver a infectarse. La OMS advierte de que no hay evidencias suficientes sobre la inmunidad que aportan los anticuerpos que genera un individuo tras superar la COVID-19 ni si protegen ante segundas infecciones.  1, fiche 3, Espagnol, - certificado%20de%20inmunidad

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Laboratory confirmation of COVID-19... consists of detection of two genomic targets [or detection] of a single target... and detection of COVID-19 virus by sequencing.  2, fiche 4, Anglais, - laboratory%20confirmation

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Tous les cas cliniques de rougeole doivent avoir une confirmation en laboratoire à moins d'avoir un lien épidémiologique avec un cas confirmé [...]  2, fiche 4, Français, - confirmation%20en%20laboratoire

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Fiche 5,  Justifications,  Anglais

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Research is on hairpin catalytic RNA, a catalytic RNA discovered and characterized here in my laboratory at Northern Illinois University. Hairpin catalytic RNA is a molecule which can be engineered to very efficiently cleave target RNA sequences in a unique and efficient reaction. The catalytic RNA can thus be used for the specific down regulation of gene expression since it can be designed to destroy mRNA. Current applications being developed are down regulation of selected genes, including those in the virus HIV-1. Thus it has potential as an AIDS therapeutic.  1, fiche 5, Anglais, - catalytic%20RNA

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Macromolécule biologique d'acide ribonucléique susceptible d'agir comme une enzyme et de catalyser des réactions chimiques.  1, fiche 5, Français, - ARN%20catalytique

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Molécula de ARN [ácido ribonucleico] que puede catalizar la ruptura química de sí misma o de otras moléculas de ARN.  1, fiche 5, Espagnol, - ARN%20catal%C3%ADtico

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The rabies antibody test is indicated for individuals who because of high risk exposure to possibly rabid animals have been previously immunized against the virus. This population typically includes veterinarians, animal control officers, laboratory personnel and other workers who come in frequent contact with potentially rabid animals. The result of this test will determine if an individual has had a successful sero-conversion after immunization.  1, fiche 6, Anglais, - rabies%20antibody%20test

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There is always the possibility of a laboratory escape of the virus due to a breakdown in biosecurity(by human or mechanical error) or even deliberate introduction  1, fiche 7, Anglais, - laboratory%20escape%20of%20the%20virus

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Aucune amplification de virus de classe 4 dans des cellules en culture ni d'expérience chez les animaux n'est envisagée. Ainsi, les risques d'accidents et de propagation de virus à l'extérieur du laboratoire sont quasi inexistants.  1, fiche 7, Français, - propagation%20de%20virus%20%C3%A0%20l%27ext%C3%A9rieur%20du%20laboratoire

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Fiche 8,  Justifications,  Anglais

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The primary interest of this laboratory is in the mechanism of cell transformation and oncogenicity of receptor protein tyrosine kinases(RPTKs). Currently, we are studying the ros oncogene, originally discovered in an avian sarcoma virus, human insulin receptor(IR) and human insulin-like growth factor I receptor(IGFR). Molecular basis for the oncogenic activation as well as signalling transduction pathways responsible for normal and oncogenic functions of those receptor PTKs are being explored. Regulation and intervention of those oncogenic RPTKs by potential suppressor "anti-oncogene" such as protein tyrosine phosphatase(PTPase) and dominant-negative mutants of downstream signalling molecules are being inquired. Finally, potential role of those and other RPTKs in the development and progression of human malignancy, particularly breast cancer, are also being examined.  1, fiche 8, Anglais, - oncogenicity

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[...] les cellules utilisées doivent être soumises à des épreuves de tumorigénicité [...]. Bien que les techniques biochimiques permettent un dosage assez précis de la quantité d'ADN dans le produit fini, une mesure indépendante de la tumorigénicité potentielle doit être également fournie.  3, fiche 8, Français, - oncog%C3%A9nicit%C3%A9

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Fiche 9,  Justifications,  Anglais

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Unlike drugs, to which HIV can develop resistance by genetically reshaping its component parts, the engineered(smart bomb) virus attacks a feature that HIV probably cannot alter without rendering itself harmless. In laboratory experiments, it reduced HIV to undetectable levels, raising the possibility of an entirely new kind of therapy for treating AIDS and maybe other viral diseases.  1, fiche 9, Anglais, - HIV%2Dhunting%20virus

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The virus doesn’t seem to infect any cells other than those infected with HIV. The method consists of reprogramming a virus, changing its natural target so that it kills another virus. However, the therapy based on injection of live viruses is unlikely to be approved easily.  1, fiche 9, Anglais, - HIV%2Dhunting%20virus

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The HIV-hunting virus has been designed by Dr. John Rose and his colleagues at Yale University School of Medicine this year. They worked with a well-understood virus that infects cattle, known as VSV, or vesicular stomatitis virus and stripped out the gene that makes its protein coat. In its place, they inserted human genes for the two proteins that constitutes the T-cell lack. This created a novel virus, coated with T-cell lock proteins avid to find HIV keys, a sort of HIV in reverse. When added to culture of infected human T-cells, the redesigned viruses sought out and killed them.  1, fiche 9, Anglais, - HIV%2Dhunting%20virus

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Fiche 10,  Justifications,  Anglais

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As well, we are continuing to explore a new approach to subunit vaccine design introduced by our laboratory a number of years ago(see Carayanniotis and Barber(1987) Nature 327, 59). By conjugation of purified protein or synthetic peptide antigens to monoclonal antibodies specific for defined cell surface determinants in vivo(e. g. class II MHC), it is possible to induce an effective antibody response to the "targeted" antigen(for recent data see Skea and Barber(1993) J. Immunol. 151, 3557). We are currently using recombinant DNA approaches to "engineer" specific B-and T-cell epitopes into selected sites on immunotargeting antibodies. In addition to our work using influenza virus as a model, we are also studying conserved B-and T-cell epitopes from HIV in order to develop a candidate AIDS vaccine.  2, fiche 10, Anglais, - immunotargeting

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Fiche 11,  Justifications,  Anglais

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Experimental substrate is developed within this facility and from the Transplant Research Surgery Laboratory, creating directly translational research in organ transplantation. Current research projects are investigating gene transfer vectorology, in vitro models of allograft rejection, and screening for genetic determinants of chronic rejection. The laboratory is fully equipped, including a tissue culture facility, cold room, recombinant virus culture incubators and thermocyclers for polymerase chain reaction assays.  1, fiche 11, Anglais, - vectorology

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L'Association française contre les myopathies (AFM) prépare l'installation pour le début de l'année 1997 d'une nouvelle unité de recherche en vectorologie sur le site du Généthon à Évry. Ce laboratoire, qui représente un investissement de 90 millions de francs sur cinq ans, se consacrera à la recherche et au développement de vecteurs pour les thérapies génique et cellulaire.  2, fiche 11, Français, - vectorologie

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