TERMIUM Plus^®

Fiche 1,  Justifications,  Anglais

Record number: 1, Textual support number: 1 DEF

A recombinant protease with activity against components of the interface between the retina and the vitreous humour, used for treatment of symptomatic vitreomacular adhesion.  3, fiche 1, Anglais, - ocriplasmin

Record number: 1, Textual support number: 1 CONT

Vitreomacular adhesion can lead to pathologic traction and macular hole. The standard treatment for severe, symptomatic vitreomacular adhesion is vitrectomy. Ocriplasmin is a recombinant protease with activity against fibronectin and laminin, components of the vitreoretinal interface.  4, fiche 1, Anglais, - ocriplasmin

Record number: 1, Textual support number: 1 OBS

[Ocriplasmin] works by dissolving the proteins that link the vitreous to the macula in this condition, thus preventing posterior detachment of the vitreous from the retina.  3, fiche 1, Anglais, - ocriplasmin

Fiche 1,  Justifications,  Français

Record number: 1, Textual support number: 1 CONT

L'ocriplasmine (ou microplasmine) est une forme tronquée de la plasmine. Elle possède une activité protéolytique contre la fibronectine et la laminine, deux composants de l'interface vitréo-rétinienne. Des études précliniques et cliniques ont suggéré que l'ocriplasmine pouvait induire une liquéfaction du vitré et favoriser un DPV [décollement postérieur du vitré] [...]  1, fiche 1, Français, - ocriplasmine

Fiche 1,  Justifications,  Espagnol

Fiche 2,  Justifications,  Anglais

Record number: 2, Textual support number: 1 CONT

The diagnosis of NVCM is... based on the presence of intraretinal cystoid spaces on OCT [optical coherence tomography] and the absence of leakage and pooling on late-phase FA [fluorescein angiography].... There are many causes of cystoid maculopathies, most of them being due to a breakdown of the inner or outer BRB [blood-retinal barrier],... and others being due to a variety of causes in the absence of fluorescein leakage, when FA is performed, referred to as NVCM. The causes of NVCM may be mechanical due to antero-posterior VMT [vitreomacular traction] or to tangential epiretinal traction or tension. Retinal dystrophies are another group of heterogeneous diseases in which cystoid spaces may occur in the macula with or without fluorescein leakage and often attributed to neuronal degeneration. Acquired dysfunction of the RPE [retinal pigment epithelium] or drug toxicity may be responsible for NVCM.  1, fiche 2, Anglais, - non%2Dvasogenic%20cystoid%20maculopathy

Fiche 2,  Justifications,  Français

Record number: 2, Textual support number: 1 CONT

[...] les maculopathies cystoïdes non vasogéniques, qui ne sont pas associées à une rupture de la barrière hématorétinienne (sans diffusion angiographique) et qui comprennent quant à elles les maladies héréditaires [...], certaines toxicités médicamenteuses (taxanes, tamoxifène), la choriorétinopathie séreuse centrale, la CAR («cancer-associated retinopathy»), le fovéoschisis du myope fort, les fossettes colobomateuses, le glaucome avancé.  1, fiche 2, Français, - maculopathie%20cysto%C3%AFde%20non%20vasog%C3%A9nique

Fiche 2,  Justifications,  Espagnol