TERMIUM Plus^®

Fiche 1,  Justifications,  Anglais

Record number: 1, Textual support number: 1 CONT

A real difference in pathogenicity between HIV-1 and HIV-2 could be significant, and it would be important to determine its molecular basis. The two viruses infect the same populations of cells, binding the same CD4 receptor, but there are some differences in their genetic material and therefore in proteins. One of the most obvious is the presence in HIV-1 of the vpu gene, which is absent in HIV-(and in SIV, for that matter). Perhaps the product of this gene, a small 16-kilodalton peptide, enpathogenicity. Similarly, HIV-2 and SIV contain the vpx gene; HIV-1 does not. If this gene's 12-kilodalton product somehow slows the proliferation or spread of the virus or reduces its ability cells, that too could help to explain why HIV-2 and SIV appear to be less regularly pathogenic than HIV-1.  1, fiche 1, Anglais, - vpx%20gene

Fiche 1,  Justifications,  Français

Record number: 1, Textual support number: 1 CONT

L'organisation du génome du HIV est plus complexe que celle des autres rétrovirus. En plus des gènes dits de structure, gag, pol et env, qui produisent les constituants de la particule virale, on trouve plusieurs gènes, plus petits situés entre les gènes pol et env. Cette région comporte le gène vif, qui est le plus grand de cette partie du génome, le gène vpr, et le gène vpx chez HIV-2 et SIV, les premiers segments des gènes encodant les protéines régulatrices Tat et Rev ainsi que dans certains isolats, le gène vpu. Un autre gène unique au virus du groupe HIV, nef, est situé dans la partie terminale du génome, après le gène env chevauchant le LTR de droite.  2, fiche 1, Français, - g%C3%A8ne%20vpx

Fiche 1,  Justifications,  Espagnol

Fiche 2,  Justifications,  Anglais

Record number: 2, Textual support number: 1 DEF

A 96-amino acid(14 kd) protein, which is incorporated into the virion. It interacts with the p6gag part of the Pr55gag precursor. Vpr detected in the cell is localized to the nucleus. Proposed functions for Vpr include the nuclear import of preintegration complexes, cell growth arrest, transactivation of cellular genes, and induction of cellular differentiation. Found in HIV-1, HIV-2, SIVmac and SIVmnd. It is homologous to VPX of SIVagm.  2, fiche 2, Anglais, - viral%20protein%20u

Record number: 2, Textual support number: 1 OBS

Glossary in molecular biology (Portions of the glossary text were taken directly or modified from definitions in the U.S. Congress Office of Technology Assessment document).  3, fiche 2, Anglais, - viral%20protein%20u

Fiche 2,  Justifications,  Français

Record number: 2, Textual support number: 1 DEF

Une des protéines du rétrovirus HIV-1 qui participe avec la protéine Vif à la maturation du virus.  2, fiche 2, Français, - prot%C3%A9ine%20virale%20u

Fiche 2,  Justifications,  Espagnol

Record number: 2, Textual support number: 1 OBS

Uno de los tres genes auxiliares del VIH [virus de la inmunodeficiencia humana].  1, fiche 2, Espagnol, - vpu

Fiche 3,  Justifications,  Anglais

Record number: 3, Textual support number: 1 DEF

A 96-amino acid(14 kd) protein, which is incorporated into the virion. It interacts with the p6gag part of the Pr55gag precursor. the Vpr detected in the cell is localized to the nucleus. Proposed funtions for Vpr include the nuclear import of preintegration complexes, cell growth arrest, transactivation of cellular genes, and induction of cellular differentiation. Found in HIV-1, HIV-2, SIVmac and SIVmnd, It is homologous to VPX of SIVmgm.  2, fiche 3, Anglais, - virus%2Dencoded%20protein

Record number: 3, Textual support number: 1 OBS

Glossary of molecular biology (portions of the glossary text were taken directly or modified from definitions in the U.S. Congress Office of Technology Assessment document).  3, fiche 3, Anglais, - virus%2Dencoded%20protein

Fiche 3,  Justifications,  Français

Record number: 3, Textual support number: 1 CONT

Le processus de transcription inverse commence pendant l'encapsidation de l'ARN. Il n'est pas initié par un ARN de transfert, comme chez les rétrovirus, mais par une protéine virale qui n'est autre que la polymérase.  3, fiche 3, Français, - prot%C3%A9ine%20virale

Record number: 3, Textual support number: 1 OBS

Équivalents français approuvés par l'Unité de recherche en vaccinologie, Laboratoire et Service d'infectiologie, Centre hospitalier de l'université Laval (CHUL), Québec.  4, fiche 3, Français, - prot%C3%A9ine%20virale

Fiche 3,  Justifications,  Espagnol

Fiche 4,  Justifications,  Anglais

Record number: 4, Textual support number: 1 DEF

Additional virion and non-virion-associated proteins produced by HIV/SIV retroviruses : Vif, Vpr, Vpu, Vpx, Nef. Although the accessory proteins are in general not necessary for viral propagation in tissue culture, they have been conserved in the different isolates; this conservation and experimental observations suggest that their role in vivo is very important.  1, fiche 4, Anglais, - accessory%20protein

Record number: 4, Textual support number: 1 OBS

Glossary in molecular biology (Portions of the glossary text were taken directly or modified from definitions in the U.S. Congress Office of Technology Assessment document).  2, fiche 4, Anglais, - accessory%20protein

Fiche 4,  Justifications,  Français

Fiche 4,  Justifications,  Espagnol