TERMIUM Plus^®

Fiche 1,  Justifications,  Anglais

Record number: 1, Textual support number: 1 DEF

A cannabinoid receptor antagonist for the adjunctive management of obesity in individuals with a BMI [body mass index] of 30 kg/m² or more, or in individuals with a BMI above 27 kg/m² in the presence of other risk factors such as type 2 diabetes or dyslipidaemia.  5, fiche 1, Anglais, - 5%2D%284%2Dchlorophenyl%29%2D1%2D%282%2C4%2Ddichlorophenyl%29%2D4%2Dmethyl%2DN%2Dpiperidin%2D1%2Dyl%2D1H%2Dpyrazole%2D3%2Dcarboxamide

Record number: 1, Textual support number: 1 CONT

Rimonabant, as a selective CB1 receptor [cannabinoid receptor 1] endocannabinoid blocker, is believed to act in two areas : the brain, where it reduces hunger, hence promoting weight loss; and in adipose tissue, where it increases levels of adiponectin, the cytokine secreted by fat tissue.  6, fiche 1, Anglais, - 5%2D%284%2Dchlorophenyl%29%2D1%2D%282%2C4%2Ddichlorophenyl%29%2D4%2Dmethyl%2DN%2Dpiperidin%2D1%2Dyl%2D1H%2Dpyrazole%2D3%2Dcarboxamide

Record number: 1, Textual support number: 1 OBS

5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N- piperidin-1-yl-1H-pyrazole-3-carboxamide: form recommended by the IUPAC (International Union of Pure and Applied Chemistry) for the systematic name corresponding to the CAS number indicated on the present record.  1, fiche 1, Anglais, - 5%2D%284%2Dchlorophenyl%29%2D1%2D%282%2C4%2Ddichlorophenyl%29%2D4%2Dmethyl%2DN%2Dpiperidin%2D1%2Dyl%2D1H%2Dpyrazole%2D3%2Dcarboxamide

Record number: 1, Textual support number: 2 OBS

H; N-: These capital letters must be italicized.  1, fiche 1, Anglais, - 5%2D%284%2Dchlorophenyl%29%2D1%2D%282%2C4%2Ddichlorophenyl%29%2D4%2Dmethyl%2DN%2Dpiperidin%2D1%2Dyl%2D1H%2Dpyrazole%2D3%2Dcarboxamide

Record number: 1, Textual support number: 3 OBS

rimonabant: United States adopted name (USAN); international nonproprietary name (INN).  7, fiche 1, Anglais, - 5%2D%284%2Dchlorophenyl%29%2D1%2D%282%2C4%2Ddichlorophenyl%29%2D4%2Dmethyl%2DN%2Dpiperidin%2D1%2Dyl%2D1H%2Dpyrazole%2D3%2Dcarboxamide

Record number: 1, Textual support number: 4 OBS

Rimonabant is currently being sold in the United Kingdom by Sanofi-Aventis and in Denmark by Sanofi-Synthelabo under the trade name Acomplia (which is the name used in 18 countries, as of 2007). Riobant, Slimona and Rimoslim are generic forms available in India. If approved in the United States, it is intended to be marketed under the name Zimulti.  8, fiche 1, Anglais, - 5%2D%284%2Dchlorophenyl%29%2D1%2D%282%2C4%2Ddichlorophenyl%29%2D4%2Dmethyl%2DN%2Dpiperidin%2D1%2Dyl%2D1H%2Dpyrazole%2D3%2Dcarboxamide

Record number: 1, Textual support number: 5 OBS

Chemical formula: C₂₂H₂₁Cl₃N₄O  9, fiche 1, Anglais, - 5%2D%284%2Dchlorophenyl%29%2D1%2D%282%2C4%2Ddichlorophenyl%29%2D4%2Dmethyl%2DN%2Dpiperidin%2D1%2Dyl%2D1H%2Dpyrazole%2D3%2Dcarboxamide

Fiche 1,  Justifications,  Français

Record number: 1, Textual support number: 1 DEF

[...] antagoniste sélectif du récepteur cannabinoïde de type 1 [utilisé comme anorexigène] qui joue un rôle dans la régulation de l'équilibre énergétique et du métabolisme glucidolipidique [et qui a] démontré son efficacité sur la perte de poids, la réduction du tour de taille et l'amélioration des paramètres lipidiques et glucidiques.  3, fiche 1, Français, - 5%2D%284%2Dchloroph%C3%A9nyl%29%2D1%2D%282%2C4%2Ddichloroph%C3%A9nyl%29%2D4%2Dm%C3%A9thyl%2DN%2Dpip%C3%A9ridin%2D1%2Dyl%2D1H%2Dpyrazole%2D3%2Dcarboxamide

Record number: 1, Textual support number: 1 CONT

Acomplia (rimonabant) est approuvé en Suisse pour le traitement des patients obèses ou en surpoids avec au moins un facteur de risque cardiovasculaire associé.  4, fiche 1, Français, - 5%2D%284%2Dchloroph%C3%A9nyl%29%2D1%2D%282%2C4%2Ddichloroph%C3%A9nyl%29%2D4%2Dm%C3%A9thyl%2DN%2Dpip%C3%A9ridin%2D1%2Dyl%2D1H%2Dpyrazole%2D3%2Dcarboxamide

Record number: 1, Textual support number: 1 OBS

5-(4-chlorophényl)-1-(2,4-dichlorophényl)-4-méthyl-N- pipéridin-1-yl-1H-pyrazole-3-carboxamide : forme recommandée par l'UICPA (Union internationale de chimie pure et appliquée) pour le nom systématique correspondant au numéro CAS indiqué sur la présente fiche.  1, fiche 1, Français, - 5%2D%284%2Dchloroph%C3%A9nyl%29%2D1%2D%282%2C4%2Ddichloroph%C3%A9nyl%29%2D4%2Dm%C3%A9thyl%2DN%2Dpip%C3%A9ridin%2D1%2Dyl%2D1H%2Dpyrazole%2D3%2Dcarboxamide

Record number: 1, Textual support number: 2 OBS

H; N- : Ces lettres majuscules s'écrivent en italique.  1, fiche 1, Français, - 5%2D%284%2Dchloroph%C3%A9nyl%29%2D1%2D%282%2C4%2Ddichloroph%C3%A9nyl%29%2D4%2Dm%C3%A9thyl%2DN%2Dpip%C3%A9ridin%2D1%2Dyl%2D1H%2Dpyrazole%2D3%2Dcarboxamide

Record number: 1, Textual support number: 3 OBS

rimonabant : dénomination commune internationale (DCI).  5, fiche 1, Français, - 5%2D%284%2Dchloroph%C3%A9nyl%29%2D1%2D%282%2C4%2Ddichloroph%C3%A9nyl%29%2D4%2Dm%C3%A9thyl%2DN%2Dpip%C3%A9ridin%2D1%2Dyl%2D1H%2Dpyrazole%2D3%2Dcarboxamide

Record number: 1, Textual support number: 4 OBS

Acomplia : Nom sous lequel la compagnie Sanofi-aventis commercialise le principe actif du rimonabant.  6, fiche 1, Français, - 5%2D%284%2Dchloroph%C3%A9nyl%29%2D1%2D%282%2C4%2Ddichloroph%C3%A9nyl%29%2D4%2Dm%C3%A9thyl%2DN%2Dpip%C3%A9ridin%2D1%2Dyl%2D1H%2Dpyrazole%2D3%2Dcarboxamide

Record number: 1, Textual support number: 5 OBS

Formule chimique : C₂₂H₂₁Cl₃N₄O  6, fiche 1, Français, - 5%2D%284%2Dchloroph%C3%A9nyl%29%2D1%2D%282%2C4%2Ddichloroph%C3%A9nyl%29%2D4%2Dm%C3%A9thyl%2DN%2Dpip%C3%A9ridin%2D1%2Dyl%2D1H%2Dpyrazole%2D3%2Dcarboxamide

Fiche 1,  Justifications,  Espagnol

Fiche 2,  Justifications,  Anglais

Record number: 2, Textual support number: 1 CONT

Ghrelin, a new obesity related peptide and endogenous ligand for growth hormone seretagogue receptor(GHS-Rs), regulates pituitary growth hormone(GH) secretion. GHS-Rs distributed on hypothalamic neurons and in the brainstem. Ghrelin participates in energy balance in rodents by decreasing fat utilization without significantly changing energy expenditure or locomotor activity. Peripheral daily administration of Ghrelin caused weight gain by reducing fat utilization in mice and rats. Intracerebroventricular administration of Ghrelin generated a dose-dependent increase in food intake and body weight  1, fiche 2, Anglais, - ghrelin

Fiche 2,  Justifications,  Français

Record number: 2, Textual support number: 1 DEF

Neuropeptide stimulant la sécrétion de l'hormone de croissance.  1, fiche 2, Français, - ghr%C3%A9line

Record number: 2, Textual support number: 1 OBS

Neuropeptide qui joue un rôle dans le métabolisme des gras.  2, fiche 2, Français, - ghr%C3%A9line

Fiche 2,  Justifications,  Espagnol

Fiche 3,  Justifications,  Anglais

Record number: 3, Textual support number: 1 CONT

Leptin was identified in 1994 as the product of a gene that is defective in an obese strain of mice, ob/ob. Injection of leptin into the obese mice led to a return to normal weight, a result that made news headlines way beyond the scientific press. Further studies have shown that weight loss is a complex process, involving impaired response to leptin or the leptin receptor.  1, fiche 3, Anglais, - leptin

Record number: 3, Textual support number: 1 OBS

The Cytokine Bulletin, Summer 1996. Leptin, an Obesity Factor. Leptin was identified in 1994 as the product of a gene that is defective in an obese strain in INTERNET at the address mentioned in c.  2, fiche 3, Anglais, - leptin

Fiche 3,  Justifications,  Français

Record number: 3, Textual support number: 1 CONT

Depuis l'isolement du gène ob en 1994, on a montré que son produit, baptisé leptine, peut corriger plusieurs types d'obésité chez la souris, liés ou non à une mutation de ce gène.  2, fiche 3, Français, - leptine

Record number: 3, Textual support number: 2 CONT

Le gène de la leptine serait bien associé aux formes extrêmes d'obésité humaine. Ce résultat est publié par les équipes du CNRS EP10 (Lille) et du service de nutrition de l'Hôtel-Dieu (Paris), alors que certaines observations commençaient à faire douter que ce gène, mis en cause dans un modèle murin d'obésité, ait un rôle dans l'affection chez l'homme. Comme la démonstration qui vient d'être apportée ne concerne que les obésités extrêmes, la question du déterminisme génétique reste toutefois ouverte pour les obésités " tout venant ".  3, fiche 3, Français, - leptine

Fiche 3,  Justifications,  Espagnol

Fiche 4,  Justifications,  Anglais

Record number: 4, Textual support number: 1 CONT

Both helper T cells and cytoxic T cells express their T cell antigen receptor in a molecular complex involving three other polypeptide chains. These three chains comprise the CD3 subunit in man. The three chains of CD3 are the [gamma] chain(molecular weight 20 kD), the [delta] chain(molecular weight 20 kD) and the [epsilon] chain(molecular weight 20 kD). These chains are non-covalently associated with each other and the ab heterodimer of the TCR(T cell receptor).  1, fiche 4, Anglais, - CD3%20subunit

Fiche 4,  Justifications,  Français

Record number: 4, Textual support number: 1 CONT

L'activation des cellules T nécessite [...] l'intervention de molécules de transduction (CD3) [...]. Parmi ces molécules spécifiques des cellules T «associées au récepteur», la molécule CD3 a un statut particulier par son association physique avec l'hétérodimère [alpha][bêta] et son rôle dans l'activation cellulaire. [...] Il s'agit d'un complexe moléculaire comprenant plusieurs chaînes polypeptidiques : [...]. Trois ont été identifiées chez l'homme et cinq chez la souris.  1, fiche 4, Français, - mol%C3%A9cule%20CD3

Fiche 4,  Justifications,  Espagnol