TERMIUM Plus^®

Fiche 1,  Justifications,  Anglais

Record number: 1, Textual support number: 1 DEF

A cannabinoid receptor antagonist for the adjunctive management of obesity in individuals with a BMI [body mass index] of 30 kg/m² or more, or in individuals with a BMI above 27 kg/m² in the presence of other risk factors such as type 2 diabetes or dyslipidaemia.  5, fiche 1, Anglais, - 5%2D%284%2Dchlorophenyl%29%2D1%2D%282%2C4%2Ddichlorophenyl%29%2D4%2Dmethyl%2DN%2Dpiperidin%2D1%2Dyl%2D1H%2Dpyrazole%2D3%2Dcarboxamide

Record number: 1, Textual support number: 1 CONT

Rimonabant, as a selective CB1 receptor [cannabinoid receptor 1] endocannabinoid blocker, is believed to act in two areas : the brain, where it reduces hunger, hence promoting weight loss; and in adipose tissue, where it increases levels of adiponectin, the cytokine secreted by fat tissue.  6, fiche 1, Anglais, - 5%2D%284%2Dchlorophenyl%29%2D1%2D%282%2C4%2Ddichlorophenyl%29%2D4%2Dmethyl%2DN%2Dpiperidin%2D1%2Dyl%2D1H%2Dpyrazole%2D3%2Dcarboxamide

Record number: 1, Textual support number: 1 OBS

5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N- piperidin-1-yl-1H-pyrazole-3-carboxamide: form recommended by the IUPAC (International Union of Pure and Applied Chemistry) for the systematic name corresponding to the CAS number indicated on the present record.  1, fiche 1, Anglais, - 5%2D%284%2Dchlorophenyl%29%2D1%2D%282%2C4%2Ddichlorophenyl%29%2D4%2Dmethyl%2DN%2Dpiperidin%2D1%2Dyl%2D1H%2Dpyrazole%2D3%2Dcarboxamide

Record number: 1, Textual support number: 2 OBS

H; N-: These capital letters must be italicized.  1, fiche 1, Anglais, - 5%2D%284%2Dchlorophenyl%29%2D1%2D%282%2C4%2Ddichlorophenyl%29%2D4%2Dmethyl%2DN%2Dpiperidin%2D1%2Dyl%2D1H%2Dpyrazole%2D3%2Dcarboxamide

Record number: 1, Textual support number: 3 OBS

rimonabant: United States adopted name (USAN); international nonproprietary name (INN).  7, fiche 1, Anglais, - 5%2D%284%2Dchlorophenyl%29%2D1%2D%282%2C4%2Ddichlorophenyl%29%2D4%2Dmethyl%2DN%2Dpiperidin%2D1%2Dyl%2D1H%2Dpyrazole%2D3%2Dcarboxamide

Record number: 1, Textual support number: 4 OBS

Rimonabant is currently being sold in the United Kingdom by Sanofi-Aventis and in Denmark by Sanofi-Synthelabo under the trade name Acomplia (which is the name used in 18 countries, as of 2007). Riobant, Slimona and Rimoslim are generic forms available in India. If approved in the United States, it is intended to be marketed under the name Zimulti.  8, fiche 1, Anglais, - 5%2D%284%2Dchlorophenyl%29%2D1%2D%282%2C4%2Ddichlorophenyl%29%2D4%2Dmethyl%2DN%2Dpiperidin%2D1%2Dyl%2D1H%2Dpyrazole%2D3%2Dcarboxamide

Record number: 1, Textual support number: 5 OBS

Chemical formula: C₂₂H₂₁Cl₃N₄O  9, fiche 1, Anglais, - 5%2D%284%2Dchlorophenyl%29%2D1%2D%282%2C4%2Ddichlorophenyl%29%2D4%2Dmethyl%2DN%2Dpiperidin%2D1%2Dyl%2D1H%2Dpyrazole%2D3%2Dcarboxamide

Fiche 1,  Justifications,  Français

Record number: 1, Textual support number: 1 DEF

[...] antagoniste sélectif du récepteur cannabinoïde de type 1 [utilisé comme anorexigène] qui joue un rôle dans la régulation de l'équilibre énergétique et du métabolisme glucidolipidique [et qui a] démontré son efficacité sur la perte de poids, la réduction du tour de taille et l'amélioration des paramètres lipidiques et glucidiques.  3, fiche 1, Français, - 5%2D%284%2Dchloroph%C3%A9nyl%29%2D1%2D%282%2C4%2Ddichloroph%C3%A9nyl%29%2D4%2Dm%C3%A9thyl%2DN%2Dpip%C3%A9ridin%2D1%2Dyl%2D1H%2Dpyrazole%2D3%2Dcarboxamide

Record number: 1, Textual support number: 1 CONT

Acomplia (rimonabant) est approuvé en Suisse pour le traitement des patients obèses ou en surpoids avec au moins un facteur de risque cardiovasculaire associé.  4, fiche 1, Français, - 5%2D%284%2Dchloroph%C3%A9nyl%29%2D1%2D%282%2C4%2Ddichloroph%C3%A9nyl%29%2D4%2Dm%C3%A9thyl%2DN%2Dpip%C3%A9ridin%2D1%2Dyl%2D1H%2Dpyrazole%2D3%2Dcarboxamide

Record number: 1, Textual support number: 1 OBS

5-(4-chlorophényl)-1-(2,4-dichlorophényl)-4-méthyl-N- pipéridin-1-yl-1H-pyrazole-3-carboxamide : forme recommandée par l'UICPA (Union internationale de chimie pure et appliquée) pour le nom systématique correspondant au numéro CAS indiqué sur la présente fiche.  1, fiche 1, Français, - 5%2D%284%2Dchloroph%C3%A9nyl%29%2D1%2D%282%2C4%2Ddichloroph%C3%A9nyl%29%2D4%2Dm%C3%A9thyl%2DN%2Dpip%C3%A9ridin%2D1%2Dyl%2D1H%2Dpyrazole%2D3%2Dcarboxamide

Record number: 1, Textual support number: 2 OBS

H; N- : Ces lettres majuscules s'écrivent en italique.  1, fiche 1, Français, - 5%2D%284%2Dchloroph%C3%A9nyl%29%2D1%2D%282%2C4%2Ddichloroph%C3%A9nyl%29%2D4%2Dm%C3%A9thyl%2DN%2Dpip%C3%A9ridin%2D1%2Dyl%2D1H%2Dpyrazole%2D3%2Dcarboxamide

Record number: 1, Textual support number: 3 OBS

rimonabant : dénomination commune internationale (DCI).  5, fiche 1, Français, - 5%2D%284%2Dchloroph%C3%A9nyl%29%2D1%2D%282%2C4%2Ddichloroph%C3%A9nyl%29%2D4%2Dm%C3%A9thyl%2DN%2Dpip%C3%A9ridin%2D1%2Dyl%2D1H%2Dpyrazole%2D3%2Dcarboxamide

Record number: 1, Textual support number: 4 OBS

Acomplia : Nom sous lequel la compagnie Sanofi-aventis commercialise le principe actif du rimonabant.  6, fiche 1, Français, - 5%2D%284%2Dchloroph%C3%A9nyl%29%2D1%2D%282%2C4%2Ddichloroph%C3%A9nyl%29%2D4%2Dm%C3%A9thyl%2DN%2Dpip%C3%A9ridin%2D1%2Dyl%2D1H%2Dpyrazole%2D3%2Dcarboxamide

Record number: 1, Textual support number: 5 OBS

Formule chimique : C₂₂H₂₁Cl₃N₄O  6, fiche 1, Français, - 5%2D%284%2Dchloroph%C3%A9nyl%29%2D1%2D%282%2C4%2Ddichloroph%C3%A9nyl%29%2D4%2Dm%C3%A9thyl%2DN%2Dpip%C3%A9ridin%2D1%2Dyl%2D1H%2Dpyrazole%2D3%2Dcarboxamide

Fiche 1,  Justifications,  Espagnol

Fiche 2,  Justifications,  Anglais

Record number: 2, Textual support number: 1 DEF

A cytokine produced by adipocytes in response to metabolic or extracellular signals.  1, fiche 2, Anglais, - adiponectin

Record number: 2, Textual support number: 1 OBS

[Adiponectin] lowers blood glucose level and reduces the level of triglycerides in the muscles and the production of fat. It may be exploited for treatment of insulin-resistant diabetes.  1, fiche 2, Anglais, - adiponectin

Fiche 2,  Justifications,  Français

Record number: 2, Textual support number: 1 DEF

Protéine de 247 acides aminés, sécrétée par les adipocytes et présente dans le plasma.  1, fiche 2, Français, - adiponectine

Record number: 2, Textual support number: 1 OBS

L'adiponectine potentialise les effets de l'insuline.  1, fiche 2, Français, - adiponectine

Fiche 2,  Justifications,  Espagnol