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The researchers who studied the German and Austrian patients ... had initially called the syndrome vaccine-induced prothrombotic immune thrombocytopenia; [two teams of researchers] now suggest a slightly simpler name: vaccine-induced immune thrombotic thrombocytopenia (VITT).  4, fiche 1, Anglais, - vaccine%2Dinduced%20immune%20thrombotic%20thrombocytopenia

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... the patients had unusual antibodies that trigger clotting reactions, which use up the body's platelets and can block blood vessels, leading to potentially deadly strokes or embolisms. The symptoms resemble a rare reaction to the drug heparin, called heparin-induced thrombocytopenia(HIT), in which the immune system makes antibodies to a complex of heparin and a protein called platelet factor 4(PF4), triggering platelets to form dangerous clots throughout the body.  4, fiche 1, Anglais, - vaccine%2Dinduced%20immune%20thrombotic%20thrombocytopenia

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La trombocitopenia trombótica inmunitaria inducida por vacunas (VITT, por sus siglas en inglés) se define como un síndrome clínico caracterizado por todas las anomalías de laboratorio y radiológicas descritas a continuación que ocurren en individuos de 4 a 30 días después de la vacunación con Ad26.COV2 (Johnson & Johnson) o ChAdOx1 nCoV-19(Oxford-A. Zeneca).  1, fiche 1, Espagnol, - trombocitopenia%20inmune%20tromb%C3%B3tica%20inducida%20por%20vacuna

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Ordinarily, heparin prevents clotting and does not affect the platelets, components of the blood that help form blood clots. Triggered by the immune system in response to heparin, HIT causes a low platelet count (thrombocytopenia).  2, fiche 2, Anglais, - heparin%2Dinduced%20thrombocytopenia

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Reacción adversa protrombótica, mediada por activación de anticuerpos antiplaquetarios (mayoritariamente IgG [inmonoglobulinas G) contra el complejo formado por el factor plaquetario y la heparina, en individuos en tratamiento con este fármaco.  1, fiche 2, Espagnol, - trombocitopenia%20inducida%20por%20heparina

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Heparin-induced thrombocytopenia with thrombosis(HITT) is a paradoxical prothrombotic complication of anticoagulant therapy. As many as 3% of patients undergoing cardiac surgery develop clinical HIT [heparin-induced thrombocytopenia] presenting as thrombocytopenia with or without thrombosis within 5–10 days of heparin exposure. Thrombotic complications associated with HIT carry a mortality rate of 5–10%.  2, fiche 3, Anglais, - heparin%2Dinduced%20thrombocytopenia%20with%20thrombosis

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