TERMIUM Plus^®

Fiche 1,  Justifications,  Anglais

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Heterologous, or recombinant, proteins are produced when recombinant DNA technology is used to ensure the expression of a gene product in an organism in which it would not normally be made.  2, fiche 1, Anglais, - recombinant%20protein

Fiche 1,  Justifications,  Français

Fiche 1,  Justifications,  Espagnol

Record number: 1, Textual support number: 1 DEF

Proteína codificada por un gen clonado.  1, fiche 1, Espagnol, - prote%C3%ADna%20recombinante

Fiche 2,  Justifications,  Anglais

Record number: 2, Textual support number: 1 CONT

Pronuclear injection is used to generate animals that express gene sequences under the control of a heterologous promoter.  2, fiche 2, Anglais, - heterologous%20promoter

Record number: 2, Textual support number: 1 OBS

Heterologous(meaning ’derived from a different organism’) refers to the fact that often the transferred protein was initially cloned from or derived from a different cell type or a different species from the recipient.  3, fiche 2, Anglais, - heterologous%20promoter

Fiche 2,  Justifications,  Français

Record number: 2, Textual support number: 1 CONT

L'injection pronucléaire est utilisée pour produire des animaux qui expriment les séquences de gènes sous le contrôle d'un promoteur hétérologue.  1, fiche 2, Français, - promoteur%20h%C3%A9t%C3%A9rologue

Fiche 2,  Justifications,  Espagnol

Fiche 3,  Justifications,  Anglais

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A heteropolymeric protein, consisting of an ordered association of functionally and structurally different enzymes, which catalyse successive steps in a chain of metabolic reactions.  4, fiche 3, Anglais, - multienzyme%20complex

Record number: 3, Textual support number: 1 CONT

The multienzyme complex is an example of heterologous protein-protein interaction in a functional complex. The known multienzyme complexes consist of 2-7 different catalytic units associated noncovalently, with no associated lipids, nucleic acids or enzymatically inactive protein.  4, fiche 3, Anglais, - multienzyme%20complex

Fiche 3,  Justifications,  Français

Record number: 3, Textual support number: 1 CONT

Les enzymes ne sont pas distribuées au hasard dans la cellule. Elles sont localisées dans divers compartiments cellulaires et fréquemment elles sont disposées de façon ordonné dans le réseau macromoléculaire de la cellule et des organites cellulaires pour former ce qu'on appelle un système multi-enzymatique.  3, fiche 3, Français, - complexe%20multienzymatique

Fiche 3,  Justifications,  Espagnol

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Fiche 4,  Justifications,  Espagnol

Fiche 5,  Justifications,  Anglais

Record number: 5, Textual support number: 1 CONT

A method for enhancing the secretion of heterologous proteins in Escherichia coli by optimizing, as opposed to simply maximizing, the translational level of a given protein is described. Random alteration of the translational initiation region(TIR) of the Heat-Stable Enterotoxin II(STII) signal sequence resulted in a library of vectors with varied translational strenghts.  1, fiche 5, Anglais, - translational%20initiation%20region

Fiche 5,  Justifications,  Français

Fiche 5,  Justifications,  Espagnol

Fiche 6,  Justifications,  Anglais

Record number: 6, Textual support number: 1 CONT

There are some questions as to methodology [concerning research in molecular and developmental genetics] Things such as possible difficulties with interpretation of data from using heterologous biochemical assays and correlating in vitro protein phosphorylation sites with in vivo sites of phosphorylation could have been better addressed....  1, fiche 6, Anglais, - protein%20phosphorylation

Record number: 6, Textual support number: 2 CONT

Protein kinase C-mediated bidirectional regulation of DNA synthesis, RB protein phosphorylation, and cyclin-dependent kinases in human vascular endothelial cells ... Agents which activate protein kinase C or otherwise enhance protein phosphorylation caused a substantial decrease in A beta production in vitro ... The muscarinic inhibition of cyclic AMP (cAMP) mediated contractile effects may not only be the result of a reduction in cAMP levels, but may also involve cAMP linked protein phosphorylation in the heart ... Recent studies in Alzheimer brains have shown aberrant protein phosphorylation, suggesting an alteration in protein kinases and/or phosphoprotein phosphatases ... [Source: PASCAL database].  2, fiche 6, Anglais, - protein%20phosphorylation

Fiche 6,  Justifications,  Français

Record number: 6, Textual support number: 1 CONT

L'exemple le plus ancien et le plus célèbre des régulations par phosphorylation de protéines est celui de la glycogène phosphorylase, déjà rencontrée comme protéine allostérique. Nous savons qu'un 2e mécanisme règle l'activité de la protéine puisqu'elle peut passer par phosphorylation d'une forme b peu active à une forme a très active. Une seule phosphorylation sur chaque sous-unité du dimère suffit [...]  1, fiche 6, Français, - phosphorylation%20de%20prot%C3%A9ines

Fiche 6,  Justifications,  Espagnol