TERMIUM Plus^®

Fiche 1,  Justifications,  Anglais

Record number: 1, Textual support number: 1 DEF

The dose-response point that marks the starting point for low-dose extrapolation.  3, fiche 1, Anglais, - point%20of%20departure

Record number: 1, Textual support number: 1 CONT

The POD may be a NOAEL [no observed adverse effect level]/LOAEL [lowest observed adverse effect level], but ideally is established from BMD [benchmark dose] modeling of the experimental data, and generally corresponds to a selected estimated low-level of response(e. g., 1 to 10% incidence for a quantal effect).  3, fiche 1, Anglais, - point%20of%20departure

Fiche 1,  Justifications,  Français

Record number: 1, Textual support number: 1 CONT

Le point de départ est généralement le LOAEL [dose minimale avec effet nocif observé] ou le NOAEL [dose sans effet nocif observé] mais pour les études les plus récentes l'utilisation de la BMD [dose repère] est préférée.  2, fiche 1, Français, - point%20de%20d%C3%A9part

Fiche 1,  Justifications,  Espagnol

Fiche 2,  Justifications,  Anglais

Record number: 2, Textual support number: 1 DEF

The lowest dose in a toxicity study that results in an observed adverse effect (usually one dosage level above the NOAEL [no-observed-adverse-effect level]).  3, fiche 2, Anglais, - lowest%2Dobserved%2Dadverse%2Deffect%20level

Record number: 2, Textual support number: 1 OBS

An adverse effect is a change in the morphology, physiology, growth, development or lifespan of an organism that results in impairment of its capacity to compensate for additional stress or an increase in its susceptibility to the harmful effects of other environmental influences.  3, fiche 2, Anglais, - lowest%2Dobserved%2Dadverse%2Deffect%20level

Record number: 2, Textual support number: 2 OBS

lowest-observed-adverse-effect level: term used by Environment Canada.  4, fiche 2, Anglais, - lowest%2Dobserved%2Dadverse%2Deffect%20level

Fiche 2,  Justifications,  Français

Record number: 2, Textual support number: 1 DEF

La plus faible dose qui, dans une étude de toxicité, produit un effet nocif observé (d'ordinaire, un niveau de dose au-dessus de la DSENO [dose sans effet nocif observé]).  2, fiche 2, Français, - dose%20minimale%20avec%20effet%20nocif%20observ%C3%A9

Record number: 2, Textual support number: 1 OBS

Un effet nocif est une altération significative de la morphologie, de la physiologie, de la croissance, du développement ou de l'espérance de vie d'un organisme, qui nuit à sa capacité de s'ajuster à un nouveau stress ou qui augmente sa susceptibilité aux effets nuisibles d'autres influences présentes dans l'environnement.  2, fiche 2, Français, - dose%20minimale%20avec%20effet%20nocif%20observ%C3%A9

Record number: 2, Textual support number: 2 OBS

dose minimale avec effet nocif observé : terme en usage à Environnement Canada.  3, fiche 2, Français, - dose%20minimale%20avec%20effet%20nocif%20observ%C3%A9

Fiche 2,  Justifications,  Espagnol

Record number: 2, Textual support number: 1 DEF

Dosis más baja determinada experimentalmente en la cual se ha observado una expresión estadística o biológica del efecto tóxico de interés.  6, fiche 2, Espagnol, - nivel%20de%20efecto%20adverso%20m%C3%A1s%20bajo%20observado

Record number: 2, Textual support number: 1 CONT

El nivel mínimo de efectos adversos observables (NMEAO), [es] el nivel más bajo en que se han observado efectos de intoxicación, generalmente empleado cuando se aplican dosificaciones intermitentes y repetidas. Tanto el NEANO [nivel de efectos adversos no observables] como el NMEAO, no incorporan [...] la variación de susceptibilidad individual, o sensibilidad de la población.  4, fiche 2, Espagnol, - nivel%20de%20efecto%20adverso%20m%C3%A1s%20bajo%20observado

Fiche 3,  Justifications,  Anglais

Record number: 3, Textual support number: 1 CONT

The next step, the quantitative dose-response analysis..., includes determining the no-observed-adverse-effect-level(NOAEL) and/or the lowest-observed-adverse-effect-level(LOAEL) for each study and type of effect. Because of the limitations associated with the use of the NOAEL, the Agency is beginning to use an additional approach, the benchmark dose approach... If the data are considered sufficient for risk assessment, and if reproductive toxicity occurs at the lowest toxic dose level(i. e., the critical effect), an RfD or RfC, based on adverse reproductive effects, could be derived.  3, fiche 3, Anglais, - toxic%20dose%20level

Record number: 3, Textual support number: 1 OBS

TDL: toxic dose level. This is sometimes also abbreviated as TDLo or TCLo. [See these other records in TERMIUM, which correspond to the related concepts "toxic dose low" and to "toxic concentration low".]  4, fiche 3, Anglais, - toxic%20dose%20level

Fiche 3,  Justifications,  Français

Fiche 3,  Justifications,  Espagnol