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Fiche 1,  Justifications,  Anglais

Record number: 1, Textual support number: 1 DEF

A type of hypersensitivity that (in contrast to immediate hypersensitivity) takes 24 to 72 hours to develop and is mediated by T lymphocytes rather than by antibodies.  1, fiche 1, Anglais, - delayed%20hypersensitivity

Record number: 1, Textual support number: 1 OBS

Delayed hypersensitivity is a term used to denote the subset of type IV hypersensitivity involving cytokine release and macrophage activation, as opposed to direct cytolysis but can be used more broadly, even sometimes being used synonymously with type IV hypersensitivity.  1, fiche 1, Anglais, - delayed%20hypersensitivity

Fiche 1,  Justifications,  Français

Record number: 1, Textual support number: 1 DEF

[Hypersensitivité qui] survient entre 24 et 36 heures après le contact antigène-anticorps.  1, fiche 1, Français, - hypersensibilit%C3%A9%20diff%C3%A9r%C3%A9e

Record number: 1, Textual support number: 1 OBS

L'hypersensibilité différée n'est pas médiée par des anticorps mais par des lymphocytes T chez des sujets non sensibilisés.  2, fiche 1, Français, - hypersensibilit%C3%A9%20diff%C3%A9r%C3%A9e

Record number: 1, Textual support number: 2 OBS

Les exemples d'hypersensitivité différée sont nombreux : réactions cutanées à la tuberculine, aux piqûres d'insectes, à des produits chimiques; réaction de rejet, etc.  1, fiche 1, Français, - hypersensibilit%C3%A9%20diff%C3%A9r%C3%A9e

Fiche 1,  Justifications,  Espagnol

Fiche 2,  Justifications,  Anglais

Record number: 2, Textual support number: 1 CONT

Activation of macrophages by bacterial lipopolysaccharide(LPS) induces transcription of genes that encode for proinflammatory regulators of the immune response. Previous work has suggested that activation of the transcription factor activator protein 1(AP-1) is one LPS-induced event that mediates this response. Consistent with this notion, we found that LPS stimulated AP-1-mediated transcription of a transfected reporter gene in the murine macrophage cell line RAW 264. 7. As AP-1 activity is regulated in part by activation of the c-Jun N-terminal kinase(JNK), which phosphorylates and subsequently increases the transcriptional activity of c-Jun, we examined whether LPS treatment of macrophages resulted in activation of this kinase.  3, fiche 2, Anglais, - jun%20N%2Dterminal%20kinase

Record number: 2, Textual support number: 1 OBS

PNAS Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-sti. Proceedings of the National Academy of Sciences Volume 93, Number 07; Pages: 2774-2778 Immunology.  4, fiche 2, Anglais, - jun%20N%2Dterminal%20kinase

Fiche 2,  Justifications,  Français

Record number: 2, Textual support number: 1 OBS

JNK  2, fiche 2, Français, - prot%C3%A9ine%20JNK

Fiche 2,  Justifications,  Espagnol

Fiche 3,  Justifications,  Anglais

Record number: 3, Textual support number: 1 DEF

An enhanced bactericidal activity of macrophages due to any increase in the number of lysosomes and in the secretion of microbicidal products. It is induced, in association with specific delayed hypersensitivity, by various intracellular parasites, such as Listeria and Salmonella.  1, fiche 3, Anglais, - macrophage%20activation

Fiche 3,  Justifications,  Français

Record number: 3, Textual support number: 1 DEF

Augmentation des fonctions des macrophages sous l'action de médiateurs produits par les lymphocytes T sensibilisés en présence de l'antigène (comme le MAF, macrophage activation factor). Il faut distinguer cette activation «fonctionnelle» de l'augmentation du nombre et peut-être de l'activité des macrophages péritonéaux consécutive à une injection de substances irritantes comme le thioglycolate de sodium, parfois aussi désignée sous le terme d'activation.  1, fiche 3, Français, - activation%20des%20macrophages

Fiche 3,  Justifications,  Espagnol