TERMIUM Plus^®

Fiche 1,  Justifications,  Anglais

Record number: 1, Textual support number: 1 CONT

A very original set of experiments carried out by the Unit of Molecular Biology of Gene Expression concerns another protein essential for mouse development that is also a transcription factor. This factor known as KBF2 or RBP-Jk is homologous to a Drosophila gene product, Su(H)(Suppressor of Hairless), which belongs to the Notch signal transduction cascade involved in regulating the competence of a cell to respond to specific developmental cues. A likely function of the Su(H) protein is to serve as an anchor on DNA for non DNA-binding transcriptional activators. This function is conserved in the Notch pathway : the activation of this transmembrane receptor likely involves a proteolytic cleavage step which releases its intracellular domain; following nuclear translocation, it activates its target genes by binding to the Su(H) protein, which is already bound to several sites in the target promoters.  2, fiche 1, Anglais, - Su%28H%29%20protein

Fiche 1,  Justifications,  Français

Record number: 1, Textual support number: 1 CONT

La protéine Su(H), impliquée dans l'activité de transmission de ce signal, semble capable de s'associer à la région intracellulaire de Notch. C'est un facteur de transcription qui se lie à certaines séquences localisées dans les promoteurs de plusieurs des gènes cibles de Notch.  1, fiche 1, Français, - prot%C3%A9ine%20Su%28H%29

Fiche 1,  Justifications,  Espagnol

Fiche 2,  Justifications,  Anglais

Record number: 2, Textual support number: 1 CONT

A mechanism known as lateral inhibition controls the hability of cells to respond to these various differentiation signals. One of the best studied example is the Notch activation pathway, which controls the differentiation of numerous cell types during development of Drosophila and C. elegans.  1, fiche 2, Anglais, - Notch%20activation%20pathway

Fiche 2,  Justifications,  Français

Record number: 2, Textual support number: 1 CONT

Au cours du développement embryonnaire des organismes multicellulaires complexes, un mécanisme nommé inhibition ou spécification latérale permet de contrôler dans l'espace et le temps la capacité des cellules de répondre à des signaux de différenciation. On a récemment mis à jour certains éléments des voies de transmission du signal par le récepteur Notch qui contrôle la différenciation de nombreux types cellulaires [...].  1, fiche 2, Français, - voie%20de%20transmission%20du%20signal%20Notch

Fiche 2,  Justifications,  Espagnol