TERMIUM Plus^®

Fiche 1,  Justifications,  Anglais

Record number: 1, Textual support number: 1 CONT

ARNI, or an angiotensin receptor/neprilysin inhibitor, is made up of two drugs put together to treat heart failure. It contains an ARB (angiotensin II receptor blocker) and a neprilysin inhibitor.  6, fiche 1, Anglais, - angiotensin%20II%20receptor%20and%20neprilysin%20inhibitor

Record number: 1, Textual support number: 2 CONT

Angiotensin II receptor–neprilysin inhibitors. Sacubitril-valsartan is a fixed dose combination of the angiotensin II receptor blocker valsartan and the neprilysin inhibitor sacubitril. ... Sacubitril/valsartan is a combination product. Sacubritil acts as a neprilysin inhibitor and works by blocking the action of neprilysin, inhibiting the breakdown of natriuretic peptides. This results in increased diuresis, vasodilation, reduction in blood pressure and work on the heart. Valsartan is an angiotensin receptor blocker and inhibits the RAAS [renin-angiotensin aldosterone system] ... to reduce the maladaptive response to cardiac failure. Neprilysin breaks down angiotensin II, so sacubitril given alone would result in an accumulation of angiotensin II. For this reason, it must be combined with an angiotensin receptor blocker to block the effect of excess angiotensin II.  2, fiche 1, Anglais, - angiotensin%20II%20receptor%20and%20neprilysin%20inhibitor

Fiche 1,  Justifications,  Français

Record number: 1, Textual support number: 1 OBS

Médicament composé de deux agents actifs qui est employé pour traiter l'insuffisance cardiaque.  2, fiche 1, Français, - inhibiteur%20de%20la%20n%C3%A9prilysine%2Fantagoniste%20des%20r%C3%A9cepteurs%20de%20l%27angiotensine%20II

Fiche 1,  Justifications,  Espagnol

Fiche 2,  Justifications,  Anglais

Record number: 2, Textual support number: 1 CONT

Angiotensin II receptor blockers do not inhibit ACE [angiotensin-converting enzymes]. Instead, they block the vasoconstricting and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the angiotensin I receptors in many tissues, especially in the vascular smooth muscle and adrenal gland tissues.  8, fiche 2, Anglais, - angiotensin%20II%20receptor%20blocker

Fiche 2,  Justifications,  Français

Record number: 2, Textual support number: 1 CONT

Les antagonistes des récepteurs de l'angiotensine II (ARA II) s'opposent à l'action de l'angiotensine II, puissant vasoconstricteur favorisant en outre la rétention hydrosodée et la sécrétion d'aldostérone.  2, fiche 2, Français, - antagoniste%20des%20r%C3%A9cepteurs%20de%20l%27angiotensine%20II

Fiche 2,  Justifications,  Espagnol

Fiche 3,  Justifications,  Anglais

Record number: 3, Textual support number: 1 DEF

A vasoactive octapeptide produced by the action of angiotensin-converting enzyme on angiotensin I [that] produces stimulation of vascular smooth muscle, promotes aldosterone production, and stimulates the sympathetic nervous system.  3, fiche 3, Anglais, - angiotensin%20II

Record number: 3, Textual support number: 1 CONT

Angiotensin II (Ang II) raises blood pressure (BP) by a number of actions, the most important ones being vasoconstriction, sympathetic nervous stimulation, increased aldosterone biosynthesis and renal actions. Other Ang II actions include induction of growth, cell migration, and mitosis of vascular smooth muscle cells, increased synthesis of collagen type I and III in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis.  4, fiche 3, Anglais, - angiotensin%20II

Fiche 3,  Justifications,  Français

Record number: 3, Textual support number: 1 CONT

Dans le sang, la rénine réagit avec un substrat d'origine hépatique, l'angiotensinogène [...], pour donner l'angiotensine I, décapeptide dépourvu d'activité biologique. L'angiotensine I est ensuite transformée par une enzyme de conversion pour donner une octapeptide, l'angiotensine II, possédant plusieurs activités biologiques. L'angiotensine II est ensuite dégradée au niveau rénal par des angiotensinases, donnant des peptides inactifs (l'angiotensine III, heptapeptide, possède encore certaines propriétés biologiques, mais son activité est moindre comparée à celle de l'angiotensine II).  2, fiche 3, Français, - angiotensine%20II

Fiche 3,  Justifications,  Espagnol