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The researchers who studied the German and Austrian patients ... had initially called the syndrome vaccine-induced prothrombotic immune thrombocytopenia; [two teams of researchers] now suggest a slightly simpler name: vaccine-induced immune thrombotic thrombocytopenia (VITT).  4, fiche 1, Anglais, - vaccine%2Dinduced%20immune%20thrombotic%20thrombocytopenia

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... the patients had unusual antibodies that trigger clotting reactions, which use up the body's platelets and can block blood vessels, leading to potentially deadly strokes or embolisms. The symptoms resemble a rare reaction to the drug heparin, called heparin-induced thrombocytopenia (HIT), in which the immune system makes antibodies to a complex of heparin and a protein called platelet factor 4 (PF4), triggering platelets to form dangerous clots throughout the body.  4, fiche 1, Anglais, - vaccine%2Dinduced%20immune%20thrombotic%20thrombocytopenia

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Fiche 1,  Justifications,  Espagnol

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La trombocitopenia trombótica inmunitaria inducida por vacunas (VITT, por sus siglas en inglés) se define como un síndrome clínico caracterizado por todas las anomalías de laboratorio y radiológicas descritas a continuación que ocurren en individuos de 4 a 30 días después de la vacunación con Ad26.COV2 (Johnson & Johnson) o ChAdOx1 nCoV-19(Oxford-A. Zeneca).  1, fiche 1, Espagnol, - trombocitopenia%20inmune%20tromb%C3%B3tica%20inducida%20por%20vacuna

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Thrombocytopenia is a condition in which you have a low blood platelet count. Platelets (thrombocytes) are colorless blood cells that help blood clot.  4, fiche 2, Anglais, - thrombocytopenia

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Thrombocytopenia means you have fewer than 150,000 platelets per microliter of circulating blood.  4, fiche 2, Anglais, - thrombocytopenia

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Diminution du nombre de plaquettes au-dessous de 150 000 par mm³ de sang circulant [...]  4, fiche 2, Français, - thrombocytop%C3%A9nie

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Descenso del nivel de plaquetas por debajo de ciertos parámetros.  2, fiche 2, Espagnol, - trombocitopenia

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Ordinarily, heparin prevents clotting and does not affect the platelets, components of the blood that help form blood clots. Triggered by the immune system in response to heparin, HIT causes a low platelet count (thrombocytopenia).  2, fiche 3, Anglais, - heparin%2Dinduced%20thrombocytopenia

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Reacción adversa protrombótica, mediada por activación de anticuerpos antiplaquetarios (mayoritariamente IgG [inmonoglobulinas G) contra el complejo formado por el factor plaquetario y la heparina, en individuos en tratamiento con este fármaco.  1, fiche 3, Espagnol, - trombocitopenia%20inducida%20por%20heparina

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Heparin-induced thrombocytopenia with thrombosis (HITT) is a paradoxical prothrombotic complication of anticoagulant therapy. As many as 3% of patients undergoing cardiac surgery develop clinical HIT [heparin-induced thrombocytopenia] presenting as thrombocytopenia with or without thrombosis within 5–10 days of heparin exposure. Thrombotic complications associated with HIT carry a mortality rate of 5–10%.  2, fiche 4, Anglais, - heparin%2Dinduced%20thrombocytopenia%20with%20thrombosis

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Fiche 5,  Justifications,  Anglais

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Cf. "Improved assay for detection of platelet specific PLA1 antibodies in neonatal alloimmune thrombocytopenia". Vox Sanguinis, 1982, vol. 43, pp. 76-81.  1, fiche 5, Anglais, - neonatal%20alloimmune%20thrombocytopenia

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Les thrombopénies néonatales allo-immunes (TNA) sont dues à une immunisation de la mère contre des antigènes portés par les plaquettes du fœtus. Dans la majorité des accidents, c'est le système PLA OU ZW qui est en cause, une femme de groupe PLA1 négatif développe un anticorps contre l'antigène PLA1 de son fœtus.  1, fiche 5, Français, - thrombop%C3%A9nie%20n%C3%A9o%2Dnatale%20allo%2Dimmune

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thrombopénie néonatale alloimmune : Source : Revue française de transfusion et immuno-hématologie, vol. 28, 1985, n° 6, p. 625.  3, fiche 5, Français, - thrombop%C3%A9nie%20n%C3%A9o%2Dnatale%20allo%2Dimmune

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Fiche 6,  Justifications,  Anglais

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[An] X-linked recessive syndrome is characterized clinically by the triad of eczema, thrombocytopenic purpura, and undue susceptibility to infection.  3, fiche 6, Anglais, - Wiskott%2DAldrich%20syndrome

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Often there is prolonged oozing from the circumcision site or bloody diarrhea during infancy. Atopic dermatitis and recurrent infections usually develop during the first year of life. Infections are caused by pneumococci and other bacteria with polysaccharide capsules, resulting in episodes of otitis media, pneumonia, meningitis, and sepsis. Later, infections with Pneumocystis carinii and the herpesviruses become more frequent.  3, fiche 6, Anglais, - Wiskott%2DAldrich%20syndrome

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Déficit immunitaire, héréditaire, de transmission récessive liée au chromosome X [...] caractérisé par l'association d'une thrombopénie, d'un eczéma, d'infections à répétition et éventuellement de manifestations auto-immunes et de lymphomes.  1, fiche 6, Français, - syndrome%20de%20Wiskott%2DAldrich

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