TERMIUM Plus^®

Fiche 1,  Justifications,  Anglais

Record number: 1, Textual support number: 1 DEF

An enzyme which is induced in cells affected with DNA viruses and which catalyses the phosphorylation of thymidine to thymidylic acid, in the process of DNA synthesis.  3, fiche 1, Anglais, - thymidine%20kinase

Record number: 1, Textual support number: 1 CONT

In papovavirus-infected cells the induced enzyme is cellular in origin, but the thymidine kinase induced by Herpesvirus is specified by the virus Genome, and differs in several properties from the cell enzyme.  3, fiche 1, Anglais, - thymidine%20kinase

Fiche 1,  Justifications,  Français

Record number: 1, Textual support number: 1 CONT

Cette enzyme virale, la thymidine kinase, n’ est présente que dans les cellules infectées.  1, fiche 1, Français, - thymidine%20kinase

Fiche 1,  Justifications,  Espagnol

Record number: 1, Textual support number: 1 DEF

Enzima que permite a una célula utilizar una vía metabólica alternativa para incorporar timidina en el ADN.  1, fiche 1, Espagnol, - timidina%20quinasa

Record number: 1, Textual support number: 1 OBS

Se utiliza como marcador seleccionable para identificar las células eucarióticas transfectadas.  1, fiche 1, Espagnol, - timidina%20quinasa

Fiche 2,  Justifications,  Anglais

Record number: 2, Textual support number: 1 CONT

In another application of gene therapy we have used an adenoviral vector that carries the gene for herpes simplex virus thymidine kinase (HSV-tk). Cells expressing HSV-tk will convert the anti-viral drug ganciclovir (GCV) to a form that is toxic to rapidly dividing cells. Using this adenoviral vector we have repeatedly shown robust tumoricidal effects in a variety of animal models of CNS tumor and will soon take this treatment to phase I clinical trials. We are extending this work to the manipulation of the CNSs immune response to tumors using adenoviral vectors that carry several cytokine genes.  1, fiche 2, Anglais, - herpes%20simplex%20virus%20thymidine%20kinase

Fiche 2,  Justifications,  Français

Record number: 2, Textual support number: 1 CONT

Traitement du glioblastome multiforme-une tumeur létale du cerveau-par transduction tumorale in vivo du gène codant la thymidine kinase du virus herpès simplex(HSV-TK), suivie par l'administration de ganciclovir, tel est l'intitulé des essais cliniques de phase II qui ont débuté en juin dernier en Belgique.  1, fiche 2, Français, - thimidine%20kinase%20du%20virus%20herp%C3%A8s%20simplex

Fiche 2,  Justifications,  Espagnol

Fiche 3,  Justifications,  Anglais

Record number: 3, Textual support number: 1 DEF

An anti-viral agent.  4, fiche 3, Anglais, - adenine%20arabinoside

Record number: 3, Textual support number: 1 OBS

Synthesized in 1960, it was subsequently found as a naturally occurring nucleoside in culture filtrates of streptomyces antibioticus. Mode of action nuclear but it probably inhibits viral DNA polymerase. It neither directly inactivates virus nor prevents attachment. It is active against herpesvirus and poxvirus; less so against adenovirus and papovirus. With the exception oncovirus the drug has no action against RNA viruses.  4, fiche 3, Anglais, - adenine%20arabinoside

Fiche 3,  Justifications,  Français

Record number: 3, Textual support number: 1 DEF

La principale substance utilisée, avant l'avènement de l'acyclovir, pour lutter contre les infections à herpèsvirus menaçant le pronostic vital, [et qui] agit également en l'absence de thymidine kinase.  2, fiche 3, Français, - vidarabine

Fiche 3,  Justifications,  Espagnol

Fiche 4,  Justifications,  Anglais

Fiche 4,  Justifications,  Français

Record number: 4, Textual support number: 1 CONT

Les produits des gènes thérapeutiques cytotoxiques(thymidine kinase du virus herpès associée à un traitement par le ganciclovir) ou cytostatiques(protéines Rb, Gax, eNOS) inhibent efficacement la prolifération des cellules musculaires lisses et l'hyperplasie de l'intima.  1, fiche 4, Français, - g%C3%A8ne%20th%C3%A9rapeutique%20cytotoxique

Fiche 4,  Justifications,  Espagnol