TERMIUM Plus^®

Fiche 1,  Justifications,  Anglais

Record number: 1, Textual support number: 1 CONT

ARNI, or an angiotensin receptor/neprilysin inhibitor, is made up of two drugs put together to treat heart failure. It contains an ARB (angiotensin II receptor blocker) and a neprilysin inhibitor.  6, fiche 1, Anglais, - angiotensin%20II%20receptor%20and%20neprilysin%20inhibitor

Record number: 1, Textual support number: 2 CONT

Angiotensin II receptor–neprilysin inhibitors. Sacubitril-valsartan is a fixed dose combination of the angiotensin II receptor blocker valsartan and the neprilysin inhibitor sacubitril. ... Sacubitril/valsartan is a combination product. Sacubritil acts as a neprilysin inhibitor and works by blocking the action of neprilysin, inhibiting the breakdown of natriuretic peptides. This results in increased diuresis, vasodilation, reduction in blood pressure and work on the heart. Valsartan is an angiotensin receptor blocker and inhibits the RAAS [renin-angiotensin aldosterone system] ... to reduce the maladaptive response to cardiac failure. Neprilysin breaks down angiotensin II, so sacubitril given alone would result in an accumulation of angiotensin II. For this reason, it must be combined with an angiotensin receptor blocker to block the effect of excess angiotensin II.  2, fiche 1, Anglais, - angiotensin%20II%20receptor%20and%20neprilysin%20inhibitor

Fiche 1,  Justifications,  Français

Record number: 1, Textual support number: 1 OBS

Médicament composé de deux agents actifs qui est employé pour traiter l'insuffisance cardiaque.  2, fiche 1, Français, - inhibiteur%20de%20la%20n%C3%A9prilysine%2Fantagoniste%20des%20r%C3%A9cepteurs%20de%20l%27angiotensine%20II

Fiche 1,  Justifications,  Espagnol

Fiche 2,  Justifications,  Anglais

Record number: 2, Textual support number: 1 DEF

A posttranscriptional genetic mechanism of eukaryotes that suppresses gene expression and in which double-stranded RNA [ribonucleic acid] cleaved into small fragments initiates the degradation of a complementary messenger RNA sequence.  4, fiche 2, Anglais, - ribonucleic%20acid%20interference

Fiche 2,  Justifications,  Français

Record number: 2, Textual support number: 1 CONT

L'interférence d'ARN [acide ribonucléique] est un mécanisme de régulation post-transcriptionnel physiologique très conservé dans l'évolution, conduisant à l'inhibition de l'expression génique. L'interférence est due au clivage des ARN double brin dans la cellule par des petites molécules d'ARN [...] qui ciblent des séquences complémentaires et entraînent la destruction de l'ARN sous l'effet d'un complexe comprenant une ribonucléase.  7, fiche 2, Français, - interf%C3%A9rence%20par%20acide%20ribonucl%C3%A9ique

Fiche 2,  Justifications,  Espagnol