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PrPsc [2 records]
Record 1 - internal organization data 2011-05-09
Record 1, English
Record 1, Subject field(s)
- Viral Diseases
- Genetics
Record 1, Main entry term, English
- PrPsc
1, record 1, English, PrPsc
correct
Record 1, Abbreviations, English
Record 1, Synonyms, English
- PrP-res 2, record 1, English, PrP%2Dres
correct
Record 1, Textual support, English
Record number: 1, Textual support number: 1 DEF
The abnormal form of the mature Prnp gene product found in tissue of transmissible spongiform encephalopathy sufferers, operationally defined as being partly resistant to digestion by proteinase K under standardized conditions. 3, record 1, English, - PrPsc
Record number: 1, Textual support number: 1 OBS
PrPsc stands for the abnormal disease-causing prion protein where the 'sc' refers to scrapie and PrP-res to the resistive prion protein or residue. 2, record 1, English, - PrPsc
Record 1, French
Record 1, Domaine(s)
- Maladies virales
- Génétique
Record 1, Main entry term, French
- PrPres
1, record 1, French, PrPres
correct
Record 1, Abbreviations, French
Record 1, Synonyms, French
- PrPsc 2, record 1, French, PrPsc
correct
Record 1, Textual support, French
Record number: 1, Textual support number: 1 DEF
Forme anormale et insoluble de la protéine prion (PrP) présente dans les tissus atteints d'une encéphalopathie spongiforme transmissible, largement résistante au processus naturel de dégradation des protéines et présentant un aspect en fibrilles ou bâtonnets. 2, record 1, French, - PrPres
Record number: 1, Textual support number: 1 OBS
Elle a été baptisée PrPres pour sa résistance partielle à la protéinase ou encore PrPsc pour scrapie. 2, record 1, French, - PrPres
Record 1, Spanish
Record 1, Campo(s) temático(s)
- Enfermedades víricas
- Genética
Record 1, Main entry term, Spanish
- PrPres
1, record 1, Spanish, PrPres
correct
Record 1, Abbreviations, Spanish
Record 1, Synonyms, Spanish
Record 1, Textual support, Spanish
Record 2 - internal organization data 1999-06-16
Record 2, English
Record 2, Subject field(s)
- Biochemistry
Record 2, Main entry term, English
- PrPSC
1, record 2, English, PrPSC
correct
Record 2, Abbreviations, English
- PrPsc 2, record 2, English, PrPsc
correct
Record 2, Synonyms, English
Record 2, Textual support, English
Record number: 2, Textual support number: 1 CONT
Scrapie, the prototype of a group of diseases which have the unique property of being both hereditary and infectious, is also exceptional in that it fails to evoke an immune response. Purification of crude scrapie preparations showed a strong association of infectivity with a membrane protein ('PrPSC'); but a protein with the same amino acid sequence ('PrPC') was subsequently also found in normal mammalian nervous tissue. It is postulated by some investigators that 'PrPSC' is itself the infectious agent, or the most important part thereof, but in papers making that proposal immunological aspects have not been addressed. Experimental evidence supporting the hypothesis of a membrane fragment as agent has likewise lately not been taken into account. A modified form of the membrane hypothesis could account for immunological as well as genetic aspects of these diseases. 1, record 2, English, - PrPSC
Record 2, French
Record 2, Domaine(s)
- Biochimie
Record 2, Main entry term, French
- PrP de la tremblante
1, record 2, French, PrP%20de%20la%20tremblante
correct, feminine noun
Record 2, Abbreviations, French
- PrPsc 2, record 2, French, PrPsc
correct, feminine noun
Record 2, Synonyms, French
Record 2, Textual support, French
Record number: 2, Textual support number: 1 CONT
Rappelons brièvement les connaissances acquises sur ces deux isoformes de la PrP (protéine du prion). On l'a vu, la protéine normale présente chez l'individu sain est facilement dégradée par les protéases. Elle a été appelée PrPc (pour cellaire) ou PrPsen (pour sensible aux protéases), afin de distinguer la forme anormale appelée PrPsc dans le cas de la tremblante (sc pour scrapie) ou PrPes pour résistante. 1, record 2, French, - PrP%20de%20la%20tremblante
Record number: 2, Textual support number: 1 OBS
protéine du prion pathologique 3, record 2, French, - PrP%20de%20la%20tremblante
Record 2, Spanish
Record 2, Textual support, Spanish
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