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Record 1 1999-03-26

English

Subject field(s)
  • Biochemistry
CONT

Defective transcription-coupled repair of oxidative base damage in Cockayne syndrome patients from XP group G. Cooper PK, Nouskipel T, Clarkson SG & Leadon SA (1997) Science 275, 990-993.

French

Domaine(s)
  • Biochimie
CONT

Les parties de l'ADN qui sont transcrites grâce à BRCA1 sont aussi celles qui sont réparées le plus rapidement. Ce phénomène, appelé TCR (transcription-coupled repair, réparation couplée à la transcription) est sous le contrôle de plusieurs gènes. Pour évaluer l'implication des protéine BRCA1 dans le TCR, le groupe de Steven Leadon, a analysé sur des cellules de souris, grâce à un test immunologique mesurant l'incorporation d'une base dans l'ADN, la vitesse de réparation de l'ADN à la suite d'une exposition à des agents mutagènes.

Spanish

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