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ACIDO DIAMINOPIMELICO [1 record]

Filter results by subject field Alphabetical list of terms

Filter results by subject field

Alphabetical list of terms

Record 1 2001-11-15

English

Subject field(s)
  • Chemical Elements and Compounds
  • Biochemistry
DEF

A compound that serves as a component of cell wall mucopeptide in some bacteria and as a source of lysine in all bacteria.

CONT

Design and synthesis of inhibitors of biosynthesis of peptidoglycan, a key constituent of bacterial cell walls and a target for broad spectrum antibiotics. Special emphasis is on blocking formation and utilization of diaminopimelic acid (DAP) as well as preventing polymerization of the polysaccharide backbone.

CONT

Lysine has two distinct biosynthetic pathways, the diaminopimelic acid pathway and the [alpha]-aminoadipic acid pathway. The diaminopimelic acid pathway operates in bacteria, some lower fungi, algae, and higher plants. It begins with condensation of pyruvate with aspartate ß-semialdehyde and ends with decarboxylation of diaminopimelate. Diaminopimelate is an important constituent of bacterial cell walls. The [alpha]-aminoadipic acid pathway is less widespread and functions in other lower fungi, in higher fungi, and in the protist Euglena.

OBS

DAP: This might be an in-house or a non-recognized abbreviation; not to be used alone, to avoid any risk of confusion.

French

Domaine(s)
  • Éléments et composés chimiques
  • Biochimie
CONT

diaminopimélate : Sel de l'acide diaminopimélique.

CONT

On utilise pour obtenir un «confinement biologique», des souches d'E. coli réceptrices d'ADN étranger qui sont exigeantes en acide diaminopimélique (DAP), substance uniquement d'origine bactérienne et peu répandue dans l'environnement. On a pu montrer à l'aide de modèles gnotoxéniques que les parois de certaines bactéries de la flore du tube digestif pouvaient servir de source de DAP aux mutants exigeants et permettre leur croissance «in vivo».

OBS

DAP : abréviation non officielle; ne pas l'utiliser seule, pour éviter tout risque de confusion.

Spanish

Campo(s) temático(s)
  • Elementos y compuestos químicos
  • Bioquímica
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