TERMIUM Plus®

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DETERMINANT MAJEUR [1 record]

Record 1 1993-02-11

English

Subject field(s)
  • Immunology
CONT

Penicillin produces immunologic response, as do most drug antigens, in almost all treated patients. However, only a small proportion of patients develop adverse symptoms or signs due to this immunologic reaction. The drug and its metabolites are small molecules and thus are haptens which must bind to protein before they will induce an immunologic response. The major metabolic product is the penicilloyl group, referred to as the major determinant.

French

Domaine(s)
  • Immunologie
CONT

[...] plusieurs produits de dégradation de la pénicilline G donnent lieu à des complexes haptènes-protéines distincts, notamment l'acide benzylpénicillénique, l'acide benzylpénicilloïque (BPO) et l'acide benzylpénamaldique. Chez l'homme, c'est le groupe BPO qui est le déterminant hapténique majeur.

CONT

[...] les déterminants reconnus comme majeurs (ou immunodominants) seraient ceux ayant la plus grande mobilité (ce qui est d'ailleurs le cas des déterminants les plus exposés à la surface de la molécule). (J.-F. Bach, P. Lesavre. Op, cit., p. 42).

Spanish

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