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DRK1 [1 record]

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Record 1 2017-04-11

English

Subject field(s)
  • Biochemistry
CONT

K+ channels are ubiquitous membrane proteins, which have a central role in the control of cell excitability. In the heart, voltage-gated delayed rectifier K+ channels, like Kv1.5, determine repolarization and the cardiac action potential plateau duration. Here we review the broader properties of cloned voltage-gated K+ channels with specific reference to the hKv1.5 channel in heart. We discuss the basic structural components of K+ channels such as the pore, voltage sensor, and fast inactivation, all of which have been extensively studied.

French

Domaine(s)
  • Biochimie
CONT

Les canaux K+ sont des protéines membranaires ubiquistes qui ont rôle central dans le contrôle de l'excitabilité des cellules. Dans le cœur, les canaux K+ rectifiants retardés potentiel-dépendants, tels que le Kv1.5, déterminent la repolarisation et la durée du plateau du potentiel d'action cardiaque. Dans cet article, nous révisons les propriétés générales de canaux K+ potentiel-dépendants clonés, en nous intéressant particulièrement au canal de type hKv1.5 cardiaque. Nous discutons des constituants structuraux de base bien connus des canaux K+, tels que le pore, celui détectant le potentiel membranaire et l'inactivation rapide.

Spanish

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