TERMIUM Plus®

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FACTEUR AJUSTEMENT PROPRE SUBSTANCES CHIMIQUES [1 record]

Record 1 2026-03-02

English

Subject field(s)
  • Toxicology
  • Collaboration with Health Canada
CONT

... chemical-specific adjustment factors (CSAFs) were developed to replace default assessment factors to address uncertainties in inter- and intraspecies extrapolation in human health risk assessments. CSAFs may consider both toxicokinetic and toxicodynamic properties. These factors can be derived for a single agent or chemical, for a class of chemicals with shared chemical or toxicological properties, and for a group of chemicals that share a mode or mechanism of action or toxicokinetic characteristics.

French

Domaine(s)
  • Toxicologie
  • Collaboration avec Santé Canada
CONT

Un grand avantage de l'application de facteurs d'ajustement propres aux substances chimiques par rapport à l'utilisation de facteurs d'incertitude ou d'ajustement allométrique par défaut est que cette approche intègre à la fois des données propres à l'espèce et des données propres au composé chimique.

Spanish

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