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FACTEUR CROISSANCE TRANSFORMANT [1 record]

Filter results by subject field Alphabetical list of terms

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Alphabetical list of terms

Record 1 2011-11-01

English

Subject field(s)
  • Biochemistry
  • Biotechnology
  • Cancers and Oncology
DEF

A protein secreted by transformed cells that can stimulate growth of normal cells.

CONT

A number of transforming growth factors have been isolated from media conditioned by tumor cells. Two of these were purified on the basis of their synergistic actions in stimulating the growth of fibroblasts in soft agar, an assay often used as an index of cell "transformation." Since cancer cells grow in soft agar, the growth factors were first thought to be mitogens involved in tumorigenesis and were called tumor growth factors. However their main role appear to be in embryonic development and in tissue repair.

French

Domaine(s)
  • Biochimie
  • Biotechnologie
  • Cancers et oncologie
CONT

Or Todaro et coll. avaient observé que les fibroblastes en culture, transformés par certains rétrovirus porteurs d'oncogènes, secrétaient dans le milieu de culture des substances capables d'imprimer à des cellules normales un comportement phénotypique proche de cellules transformées. Ces facteurs que l'on a appelés facteur de croissance transformant (TGF) ont été isolés et caractérisés chimiquement.

Spanish

Campo(s) temático(s)
  • Bioquímica
  • Biotecnología
  • Tipos de cáncer y oncología
DEF

Proteína segregada por un tumor que estimula la multiplicación de las células cancerígenas.

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