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Record 1 2007-11-05

English

Subject field(s)
  • Toxicology
DEF

A snake toxin that [is] a very powerful inhibitor of acetylcholinesterase, an enzyme that terminates impulse transmission at cholinergic synapses.

French

Domaine(s)
  • Toxicologie
CONT

Les fasciculines sont des toxines inhibitrices de l'acétylcholinestérase (AChE), enzyme qui hydrolyse l'ACh [acétylcholine] présente en excès dans la fente synaptique. Son inhibition conduit à une augmentation de la concentration d'ACh et par conséquent à une «surstimulation» des récepteurs nicotiniques post-synaptiques, aboutissant à une fibrillation musculaire et finalement à une paralysie.

Spanish

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