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GLUCOSE TOXICITY [1 record]

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Record 1 2024-10-30

English

Subject field(s)
  • Cytology
  • Biochemistry
CONT

The concept that chronic hyperglycemia induces a deterioration of beta-cell function was developed on observing that any hypoglycemic strategy can improve plasma insulin levels after OGTT [oral glucose tolerance test] in diabetes ... The deleterious effect of hyperglycemia was subsequently named glucotoxicity and encompasses glucose utilization by skeletal muscle.

French

Domaine(s)
  • Cytologie
  • Biochimie
CONT

L'excès chronique de glucose et de lipides circulants est pathogène avec des effets peut-être synergiques. L'hyperglycémie chronique, la dyslipidémie et l'excès d'acides gras et de triglycérides circulants, ainsi que des taux élevés de cytokines pro-inflammatoires, associés à l'insulinorésistance, sont les caractéristiques biologiques du sujet diabétique obèse. L'hyperglycémie chronique est toxique pour de nombreux tissus et organes, cellules β comprises (glucotoxicité) [...]

Key term(s)
  • gluco-toxicité

Spanish

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