TERMIUM Plus®

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HYDROPHILIC MATRIX [1 record]

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Record 1 2008-02-08

English

Subject field(s)
  • Pharmaceutical Manufacturing
DEF

A matrix consisting of one or several active agents mixed with a gel compound that releases the active agents slowly as the gel becomes hydrated in the gastrointestinal tract.

French

Domaine(s)
  • Fabrication des produits pharmaceutiques
CONT

Les matrices hydrophiles résultent du mélange d'une ou de plusieurs substances actives avec un agent gélifiant. La libération se déroule en plusieurs étapes. Au contact de l'eau ou des fluides digestifs, une très petite fraction de la substance active se dissout immédiatement. Puis la pénétration progressive du solvant permet l'hydratation du système et la gélification des macromolécules, lesquelles forment une couche visqueuse de plus en plus épaisse à partir de laquelle la substance médicamenteuse est libérée après dissolution et diffusion dans le gel.

Spanish

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