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MOTIF HELICE-BOUCLE-HELICE [1 record]
Record 1 - internal organization data 1991-07-17
Record 1, English
Record 1, Subject field(s)
- Biochemistry
- Molecular Biology
Record 1, Main entry term, English
- helix-loop-helix motif
1, record 1, English, helix%2Dloop%2Dhelix%20motif
correct
Record 1, Abbreviations, English
Record 1, Synonyms, English
Record 1, Textual support, English
Record number: 1, Textual support number: 1 DEF
We isolated full-length cDNAs encoding the 43-kD form of human upstream stimulatory factor (USF), a cellular factor required for efficient transcription of the adenovirus major late (AdML) promoter in vitro. Sequence analysis showed USF to be a member of the c-myc-related family of DNA-binding proteins. Using proteins translated in vitro, we identified a DNA-binding domain near the carboxyl terminus, which includes both a helix-loop-helix motif and a leucine repeat. 1, record 1, English, - helix%2Dloop%2Dhelix%20motif
Record number: 1, Textual support number: 1 OBS
Tiré du périodique Américain: Genes & development, 1990, 4 (10), 1730-1740. 1, record 1, English, - helix%2Dloop%2Dhelix%20motif
Record 1, French
Record 1, Domaine(s)
- Biochimie
- Biologie moléculaire
Record 1, Main entry term, French
- motif hélice-boucle-hélice
1, record 1, French, motif%20h%C3%A9lice%2Dboucle%2Dh%C3%A9lice
correct
Record 1, Abbreviations, French
Record 1, Synonyms, French
Record 1, Textual support, French
Record number: 1, Textual support number: 1 CONT
Il existe une grande famille de protéines se liant à l'ADN, exerçant une activité d'inducteurs de différenciation et de modulateurs de transcription, caractérisée par la présence d'un motif protéique dit "hélice-boucle-hélice" localisé à proximité d'une région basique. Le motif hélice-boucle-hélice (HLH, helix-loop-helix) assure la dimérisation de ces protéines, qui se lient sous la forme de dimères à l'ADN par leurs régions basiques. 1, record 1, French, - motif%20h%C3%A9lice%2Dboucle%2Dh%C3%A9lice
Record 1, Key term(s)
- HLH
Record 1, Spanish
Record 1, Textual support, Spanish
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