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MOTIF RECONNAISSANCE PROTO-ESPACEUR [1 record]

Record 1 2026-02-13

English

Subject field(s)
  • Genetics
CONT

A protospacer adjacent motif (PAM) is a 2–6-base pair DNA sequence immediately following the DNA sequence targeted by the Cas9 nuclease in the CRISPR bacterial adaptive immune system.

CONT

A significant site called PAM ... is critical in CRISPR-Cas selective recognition for its target foreign protospacer sequence. The well documented characteristic of all CRISPR-Cas types is their ability to find and cleave target invader sequences upon the recognition of the highly conserved short PAMs.

Key term(s)
  • protospacer-adjacent motif
  • protospacer-adjacent motif sequence
  • proto-spacer adjacent motif

French

Domaine(s)
  • Génétique
DEF

Séquence de 2 à 6 paires de bases qui doit être préalablement reconnue par une endodésoxyribonucléase pour que celle-ci opère la coupure de l'ADN.

OBS

motif de reconnaissance du proto-espaceur; motif de reconnaissance : désignations et définition publiées au Journal officiel de la République française le 28 mars 2018.

Spanish

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