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NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR [1 record]
Record 1 - internal organization data 2006-08-30
Record 1, English
Record 1, Subject field(s)
- Medication
Record 1, Main entry term, English
- nucleoside reverse transcriptase inhibitor
1, record 1, English, nucleoside%20reverse%20transcriptase%20inhibitor
correct
Record 1, Abbreviations, English
- NARTI 1, record 1, English, NARTI
correct
Record 1, Synonyms, English
Record 1, Textual support, English
Record number: 1, Textual support number: 1 DEF
An agent (e.g., AZT, 3TC, abacavir) that mimics one of the building blocks of genetic material [and] suppress retrovirus replication by interfering with the reverse transcriptase enzyme, causing premature termination of DNA copying. 1, record 1, English, - nucleoside%20reverse%20transcriptase%20inhibitor
Record 1, French
Record 1, Domaine(s)
- Médicaments
Record 1, Main entry term, French
- inhibiteur nucléosidique de la transcriptase inverse
1, record 1, French, inhibiteur%20nucl%C3%A9osidique%20de%20la%20transcriptase%20inverse
correct, masculine noun
Record 1, Abbreviations, French
- INTI 1, record 1, French, INTI
correct, masculine noun
Record 1, Synonyms, French
Record 1, Textual support, French
Record number: 1, Textual support number: 1 CONT
[Les] inhibiteurs nucléosidiques de la transcriptase inverse (INTI) [sont des] anti-rétroviraux [actifs] sur VIH-1 et VIH-2. [Ces] analogues de bases nucléiques nécessitent pour être actifs d'être phosphorylés dans le milieu intra-cellulaire. Ils rentrent ensuite en compétition avec les substrats naturels de la transcriptase inverse et inhibent l'action de cette dernière. Ils bloquent ainsi la fabrication d'ADN pro-viral. 1, record 1, French, - inhibiteur%20nucl%C3%A9osidique%20de%20la%20transcriptase%20inverse
Record 1, Spanish
Record 1, Campo(s) temático(s)
- Medicamentos
Record 1, Main entry term, Spanish
- inhibidor de la transcriptasa inversa análogo del nucleósido
1, record 1, Spanish, inhibidor%20de%20la%20transcriptasa%20inversa%20an%C3%A1logo%20del%20nucle%C3%B3sido
masculine noun
Record 1, Abbreviations, Spanish
Record 1, Synonyms, Spanish
Record 1, Textual support, Spanish
Record number: 1, Textual support number: 1 DEF
Medicamento antirretroviral análogo de los nucleósidos cuya estructura química constituye una versión modificada de un nucleósido natural. Este compuesto suprime la duplicación de los retrovirus al inactivar la enzima transcriptasa inversa. Los análogos de los nucleósidos causan terminación prematura de la cadena de ADN provírico (precursor vírico). Todos estos inhibidores exigen fosforilación en las células anfitrionas antes de su incorporación al ADN vírico. 1, record 1, Spanish, - inhibidor%20de%20la%20transcriptasa%20inversa%20an%C3%A1logo%20del%20nucle%C3%B3sido
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