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OCRIPLASMINE [1 record]

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Record 1 2026-03-27

English

Subject field(s)
  • Biochemistry
  • Genetics
  • Medication
  • Visual Disorders
DEF

A recombinant protease with activity against components of the interface between the retina and the vitreous humour, used for treatment of symptomatic vitreomacular adhesion.

CONT

Vitreomacular adhesion can lead to pathologic traction and macular hole. The standard treatment for severe, symptomatic vitreomacular adhesion is vitrectomy. Ocriplasmin is a recombinant protease with activity against fibronectin and laminin, components of the vitreoretinal interface.

OBS

[Ocriplasmin] works by dissolving the proteins that link the vitreous to the macula in this condition, thus preventing posterior detachment of the vitreous from the retina.

French

Domaine(s)
  • Biochimie
  • Génétique
  • Médicaments
  • Troubles de la vision
CONT

L'ocriplasmine (ou microplasmine) est une forme tronquée de la plasmine. Elle possède une activité protéolytique contre la fibronectine et la laminine, deux composants de l'interface vitréo-rétinienne. Des études précliniques et cliniques ont suggéré que l'ocriplasmine pouvait induire une liquéfaction du vitré et favoriser un DPV [décollement postérieur du vitré] [...]

Spanish

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TERMIUM Plus®, the Government of Canada's terminology and linguistic data bank
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