TERMIUM Plus^®

Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 DEF

A lipase inhibitor that aids weight loss by reversibly binding to the active center of the enzyme lipase, preventing the digestion and absorption of some dietary fats.  3, record 1, English, - %5B%282S%29%2D1%2D%5B%282S%2C3S%29%2D3%2Dhexyl%2D4%2Doxo%2Doxetan%2D2%2Dyl%5Dtridecan%2D2%2Dyl%5D%20N%2Dformyl%2DL%2Dleucinate

Record number: 1, Textual support number: 1 CONT

Orlistat, when used in conjunction with a mildly hypocaloric diet, is indicated for obesity management including weight loss and weight maintenance. ... Orlistat is indicated for obese patients with a BMI [body mass index] [greater than or equal to] 30 kg/m² or a BMI [greater than or equal to]27 kg/m² in the presence of other risk factors (e.g. hypertension, type 2 diabetes, dyslipidemia, excess visceral fat).  4, record 1, English, - %5B%282S%29%2D1%2D%5B%282S%2C3S%29%2D3%2Dhexyl%2D4%2Doxo%2Doxetan%2D2%2Dyl%5Dtridecan%2D2%2Dyl%5D%20N%2Dformyl%2DL%2Dleucinate

Record number: 1, Textual support number: 1 OBS

[(2S)-1-[(2S,3S)-3-hexyl-4-oxo-oxetan-2-yl]tridecan-2-yl] N-formyl-L-leucinate: The capital letter "N-" must be italicized; The letter "L-" is a small capital; form recommended by the IUPAC (International Union of Pure and Applied Chemistry) for the systematic name corresponding to the CAS number indicated on the present record.  1, record 1, English, - %5B%282S%29%2D1%2D%5B%282S%2C3S%29%2D3%2Dhexyl%2D4%2Doxo%2Doxetan%2D2%2Dyl%5Dtridecan%2D2%2Dyl%5D%20N%2Dformyl%2DL%2Dleucinate

Record number: 1, Textual support number: 2 OBS

orlistat: international nonproprietary name (INN).  1, record 1, English, - %5B%282S%29%2D1%2D%5B%282S%2C3S%29%2D3%2Dhexyl%2D4%2Doxo%2Doxetan%2D2%2Dyl%5Dtridecan%2D2%2Dyl%5D%20N%2Dformyl%2DL%2Dleucinate

Record number: 1, Textual support number: 3 OBS

Xenical (Roche): Name under which the active ingredient is sold.  5, record 1, English, - %5B%282S%29%2D1%2D%5B%282S%2C3S%29%2D3%2Dhexyl%2D4%2Doxo%2Doxetan%2D2%2Dyl%5Dtridecan%2D2%2Dyl%5D%20N%2Dformyl%2DL%2Dleucinate

Record number: 1, Textual support number: 4 OBS

Chemical formula: C₂₉H₅₃NO₅  5, record 1, English, - %5B%282S%29%2D1%2D%5B%282S%2C3S%29%2D3%2Dhexyl%2D4%2Doxo%2Doxetan%2D2%2Dyl%5Dtridecan%2D2%2Dyl%5D%20N%2Dformyl%2DL%2Dleucinate

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 DEF

Médicament qui agit contre l'obésité en inhibant, dans la lumière du tube digestif, l'activité de la lipase pancréatique, diminuant ainsi l'absorption des graisses.  3, record 1, French, - N%2Dformyl%2DL%2Dleucinate%20de%20%282S%29%2D1%2D%5B%282S%2C3S%29%2D3%2Dhexyl%2D4%2Doxo%2Dox%C3%A9tan%2D2%2Dyl%5Dtrid%C3%A9can%2D2%2Dyle

Record number: 1, Textual support number: 1 CONT

L'orlistat (Xenical). Ce médicament a pour effet d'entraver l'enzyme responsable de l'absorption des graisses dans le tube digestif. Il empêche ainsi l'absorption d'environ 30 % des graisses alimentaires (triglycérides), ce qui équivaut à une réduction calorique de 150 à 200 calories/jour pour un apport journalier de 1800 calories. Les graisses non absorbées sont éliminées dans les selles.  4, record 1, French, - N%2Dformyl%2DL%2Dleucinate%20de%20%282S%29%2D1%2D%5B%282S%2C3S%29%2D3%2Dhexyl%2D4%2Doxo%2Dox%C3%A9tan%2D2%2Dyl%5Dtrid%C3%A9can%2D2%2Dyle

Record number: 1, Textual support number: 1 OBS

N-formyl-L-leucinate de (2S)-1-[(2S,3S)-3-hexyl-4-oxo-oxétan-2-yl]tridécan-2-yle : La lettre majuscule «N-» s'écrit en italique; la lettre «L-» est une petite majuscule; forme recommandée par l'UICPA (Union internationale de chimie pure et appliquée) pour le nom systématique correspondant au numéro CAS indiqué sur la présente fiche.  1, record 1, French, - N%2Dformyl%2DL%2Dleucinate%20de%20%282S%29%2D1%2D%5B%282S%2C3S%29%2D3%2Dhexyl%2D4%2Doxo%2Dox%C3%A9tan%2D2%2Dyl%5Dtrid%C3%A9can%2D2%2Dyle

Record number: 1, Textual support number: 2 OBS

orlistat: dénomination commune internationale (DCI).  1, record 1, French, - N%2Dformyl%2DL%2Dleucinate%20de%20%282S%29%2D1%2D%5B%282S%2C3S%29%2D3%2Dhexyl%2D4%2Doxo%2Dox%C3%A9tan%2D2%2Dyl%5Dtrid%C3%A9can%2D2%2Dyle

Record number: 1, Textual support number: 3 OBS

Xenical (Roche) : Nom sous lequel le principe actif est commercialisé.  5, record 1, French, - N%2Dformyl%2DL%2Dleucinate%20de%20%282S%29%2D1%2D%5B%282S%2C3S%29%2D3%2Dhexyl%2D4%2Doxo%2Dox%C3%A9tan%2D2%2Dyl%5Dtrid%C3%A9can%2D2%2Dyle

Record number: 1, Textual support number: 4 OBS

Formule chimique : C₂₉H₅₃NO₅  5, record 1, French, - N%2Dformyl%2DL%2Dleucinate%20de%20%282S%29%2D1%2D%5B%282S%2C3S%29%2D3%2Dhexyl%2D4%2Doxo%2Dox%C3%A9tan%2D2%2Dyl%5Dtrid%C3%A9can%2D2%2Dyle

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 OBS

Methyl analog of dextrorphan that shows high affinity binding to several regions of the brain, including the medullary cough center.... It is one of the widely used antitussives, and is also used to study the involvement of glutamate receptors in neurotoxicity.  1, record 2, English, - dextromethorphan

Record number: 2, Textual support number: 2 OBS

Chemical formula: C₁₈H₂₅NO  3, record 2, English, - dextromethorphan

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 CONT

Santé Canada présente un aperçu des éléments probants en ce qui a trait à l'innocuité et à l'efficacité des médicaments en vente libre contre la toux et le rhume destinés aux enfants de moins de 12 ans qui contiennent les ingrédients suivants [...] l'antitussif dextrométhorphane [...]  1, record 2, French, - dextrom%C3%A9thorphane

Record number: 2, Textual support number: 1 OBS

Formule chimique : C₁₈H₂₅NO  2, record 2, French, - dextrom%C3%A9thorphane

Record 2,  Textual support,  Spanish

Record number: 2, Textual support number: 1 OBS

Fórmula química: C₁₈H₂₅NO  2, record 2, Spanish, - dextrometorfano

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 DEF

Method based on the covalent attachment of enzymes to water insoluble matrices. It is the most widespread and one of the most investigated approaches to enzyme immobilisation. The selection of conditions for immobilization is more difficult than in the cases of the other carrier binding methods described, and frequently involves more complicated and less mild conditions than the other methods, but, since covalent bonds are being formed, stable immobilized enzyme preparations which do not leach enzyme into solution in the presence of substrate or high ionic concentration solutions are formed in almost all cases. The immobilization of an enzyme by covalent attachment to a support matrix must involve only functional groups of the enzyme that are not essential for catalytic action, and therefore no reagents must be used which could affect the binding and active sites of the enzyme.  2, record 3, English, - covalent%20binding

Record number: 3, Textual support number: 1 CONT

The reaction conditions required for covalent binding are relatively complicated and not particularly mild. Therefore, in some cases, covalent binding alters the conformational structure and active center of the enzyme, resulting in major loss of activity and/or changes of substrate specificity.  3, record 3, English, - covalent%20binding

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 DEF

Technique largement employée dans le cas des enzymes qui met en jeu une réaction chimique créant une liaison irréversible entre la molécule enzymatique et les groupes réactifs du support. A ce type de liaison se surajoutent toujours des phénomènes d'adsorption électrostatique qui consolident la fixation.  2, record 3, French, - fixation%20par%20liaison%20covalente

Record number: 3, Textual support number: 1 CONT

L'enzyme fixée à un support soluble ou insoluble peut très facilement être récupérée en fin de réaction et être réemployé plusieurs fois et même fonctionner en continu dans des réacteurs. Il existe trois grands types d'immobilisation des enzymes : l'inclusion, l'adsorption et la fixation par liaison covalente.  3, record 3, French, - fixation%20par%20liaison%20covalente

Record 3,  Textual support,  Spanish

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 CONT

Immobilization of enzymes by covalent binding or cross-linking is carried out under relatively severe conditions in comparison with those of physical adsorption or ionic binding. Thus, in the former two cases, conformational change of the enzyme structure, and partial destruction of the active center may occur.  1, record 4, English, - enzyme%20structure

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 CONT

Quoique pendant des décades les organiciens aient formulé des hypothèses spéculatives sur la manière dont les groupes latéraux spécifiques des acides aminés peuvent accélérer certaines réactions chimiques, il fallut attendre une structure tridimensionnelle détaillée avant de disposer d'explications convaincantes. C'est ce que fournirent pour la première fois à Londres en 1967 D.C. Phillips et ses collègues de la Royal Institution, en déchiffrant la structure d'une enzyme, le lysozyme. La détermination de la structure tridimensionnelle les mit en mesure de proposer un mécanisme chimique précis de dégradation des chaînes de polysaccharides spécifiques par le lysozyme.  1, record 4, French, - structure%20d%27une%20enzyme

Record 4,  Textual support,  Spanish

Record 5,  Textual support,  English

Record number: 5, Textual support number: 1 CONT

The physical adsorption method for the immobilization of enzyme is based on the physical adsorption of enzyme protein on the surface of water-insoluble carriers. This method often causes little or no conformational change of the enzyme protein, or destruction of its active center. Accordingly, if a suitable carrier for the target enzyme is found, this method may be both simple and effective. However, this method has the disadvantage that the adsorbed enzyme may leak from the carrier during utilization, because the binding force between the enzyme protein and carrier is weak.  1, record 5, English, - adsorbed%20enzyme

Record 5,  Textual support,  French

Record number: 5, Textual support number: 1 CONT

L'immobilisation par adsorption met en jeu un grand nombre de forces d'interactions de faible énergie entre le support solide et la protéine : interactions de Van der WAALS, liaisons hydrogène ou liaisons hydrophobes. (...) Différents paramètres vont influer sur la quantité d'enzyme fixée et sur la solidité des liaisons créées. - Concentration en protéine enzymatique (...) - Force ionique du milieu (...) - Température (...) - pH (...) - Taille des particules et nature du support : La masse d'enzyme adsorbée croît avec l'aire spécifique et donc avec la finesse des particules du support, mais en deçà d'une certaine taille, les risques de colmatage dans les réacteurs deviennent importants.  1, record 5, French, - enzyme%20adsorb%C3%A9e

Record 5,  Textual support,  Spanish

Record 6,  Textual support,  English

Record number: 6, Textual support number: 1 CONT

Fold-over braid... is decorative as well as utilitarian. Both edges are finished; braid is folded in half, slightly off center, for easy application when binding or trimming an edge. Available in various colors and designs, usually by the yard.  1, record 6, English, - fold%2Dover%20braid

Record 6,  Textual support,  French

Record number: 6, Textual support number: 1 CONT

La tresse repliée est utile et décorative. Ses deux bords sont finis; sa pliure est légèrement excentrée pour faciliter son application sur les bords à border ou à garnir. Disponible à la verge en plusieurs coloris et motifs.  1, record 6, French, - tresse%20repli%C3%A9e

Record 6,  Textual support,  Spanish