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CRISPR [5 records]
Record 1 - internal organization data 2026-02-13
Record 1, English
Record 1, Subject field(s)
- Genetics
Record 1, Main entry term, English
- protospacer adjacent motif
1, record 1, English, protospacer%20adjacent%20motif
correct, noun
Record 1, Abbreviations, English
- PAM 2, record 1, English, PAM
correct, noun
Record 1, Synonyms, English
- protospacer adjacent motif sequence 3, record 1, English, protospacer%20adjacent%20motif%20sequence
correct, noun
- PAM sequence 4, record 1, English, PAM%20sequence
correct, noun
Record 1, Textual support, English
Record number: 1, Textual support number: 1 CONT
A protospacer adjacent motif(PAM) is a 2–6-base pairDNA sequence immediately following the DNA sequence targeted by the Cas9 nuclease in the CRISPR bacterial adaptive immune system. 5, record 1, English, - protospacer%20adjacent%20motif
Record number: 1, Textual support number: 2 CONT
A significant site called PAM... is critical in CRISPR-Cas selective recognition for its target foreign protospacer sequence. The well documented characteristic of all CRISPR-Cas types is their ability to find and cleave target invader sequences upon the recognition of the highly conserved short PAMs. 6, record 1, English, - protospacer%20adjacent%20motif
Record 1, Key term(s)
- protospacer-adjacent motif
- protospacer-adjacent motif sequence
- proto-spacer adjacent motif
Record 1, French
Record 1, Domaine(s)
- Génétique
Record 1, Main entry term, French
- motif de reconnaissance du proto-espaceur
1, record 1, French, motif%20de%20reconnaissance%20du%20proto%2Despaceur
correct, masculine noun
Record 1, Abbreviations, French
Record 1, Synonyms, French
- motif de reconnaissance du protoespaceur 2, record 1, French, motif%20de%20reconnaissance%20du%20protoespaceur
correct, masculine noun
- motif de reconnaissance 1, record 1, French, motif%20de%20reconnaissance
correct, masculine noun
Record 1, Textual support, French
Record number: 1, Textual support number: 1 DEF
Séquence de 2 à 6 paires de bases qui doit être préalablement reconnue par une endodésoxyribonucléase pour que celle-ci opère la coupure de l'ADN. 1, record 1, French, - motif%20de%20reconnaissance%20du%20proto%2Despaceur
Record number: 1, Textual support number: 1 OBS
motif de reconnaissance du proto-espaceur; motif de reconnaissance : désignations et définition publiées au Journal officiel de la République française le 28 mars 2018. 2, record 1, French, - motif%20de%20reconnaissance%20du%20proto%2Despaceur
Record 1, Spanish
Record 1, Textual support, Spanish
Record 2 - internal organization data 2026-02-13
Record 2, English
Record 2, Subject field(s)
- Biochemistry
- Genetics
Record 2, Main entry term, English
- CRISPR-associated protein 9
1, record 2, English, CRISPR%2Dassociated%20protein%209
correct, noun
Record 2, Abbreviations, English
- Cas9 2, record 2, English, Cas9
correct, noun
Record 2, Synonyms, English
- CRISPR-associated sequence 9 3, record 2, English, CRISPR%2Dassociated%20sequence%209
correct, noun
- Cas9 4, record 2, English, Cas9
correct, noun
- Cas9 4, record 2, English, Cas9
Record 2, Textual support, English
Record number: 2, Textual support number: 1 CONT
CRISPR-associated protein 9... is an enzyme capable of "cutting" DNA. Modified RNA [ribonucleic acid] attached to the enzyme is used to recognize a DNA sequence, and the... enzyme cuts the DNA at the targeted location. 5, record 2, English, - CRISPR%2Dassociated%20protein%209
Record number: 2, Textual support number: 1 OBS
CRISPR : clustered regularly interspaced short palindromic repeats. 6, record 2, English, - CRISPR%2Dassociated%20protein%209
Record 2, Key term(s)
- CRISPR-associated protein nine
- CRISPR-associated sequence nine
- Cas-9
- Cas 9
- Cas nine
Record 2, French
Record 2, Domaine(s)
- Biochimie
- Génétique
Record 2, Main entry term, French
- endodésoxyribonucléase 9
1, record 2, French, endod%C3%A9soxyribonucl%C3%A9ase%209
correct, feminine noun
Record 2, Abbreviations, French
Record 2, Synonyms, French
- enzyme Cas9 2, record 2, French, enzyme%20Cas9
correct, see observation, masculine and feminine noun
Record 2, Textual support, French
Record number: 2, Textual support number: 1 DEF
Enzyme qui, positionnée grâce à son ARN [acide ribonucléique] guide, coupe les deux brins d'un ADN porteur d'un motif de reconnaissance du proto-espaceur dans la région où la séquence d'un brin de l'ADN est complémentaire de celle de l'ARN guide. 1, record 2, French, - endod%C3%A9soxyribonucl%C3%A9ase%209
Record number: 2, Textual support number: 1 OBS
enzyme Cas9 : désignation dont le genre peut être masculin ou féminin. 3, record 2, French, - endod%C3%A9soxyribonucl%C3%A9ase%209
Record number: 2, Textual support number: 2 OBS
endodésoxyribonucléase 9 : désignation et définition publiées au Journal officiel de la République française le 4 février 2021. 3, record 2, French, - endod%C3%A9soxyribonucl%C3%A9ase%209
Record 2, Key term(s)
- endodésoxyribonucléase neuf
- enzyme Cas-9
- enzyme Cas 9
Record 2, Spanish
Record 2, Textual support, Spanish
Record 3 - internal organization data 2026-01-07
Record 3, English
Record 3, Subject field(s)
- Genetics
Record 3, Main entry term, English
- guide ribonucleic acid
1, record 3, English, guide%20ribonucleic%20acid
correct, noun
Record 3, Abbreviations, English
- gRNA 1, record 3, English, gRNA
correct, noun
Record 3, Synonyms, English
- guide RNA 2, record 3, English, guide%20RNA
correct, noun
- gRNA 3, record 3, English, gRNA
correct, noun
- gRNA 3, record 3, English, gRNA
Record 3, Textual support, English
Record number: 3, Textual support number: 1 CONT
Guide RNAs (gRNAs) are tiny RNA [ribonucleic acid] transcripts that guide the editing machinery through base-pairing with the mRNAs [messenger ribonucleic acids] in edited regions. gRNAs are complementary to small segments of the fully edited mRNAs, and thus serve as mini-templates to guide the addition and deletion of Us from the pre-edited mRNA as they form a locally double-stranded RNA helix. 4, record 3, English, - guide%20ribonucleic%20acid
Record number: 3, Textual support number: 2 CONT
No one studying molecular biology can escape the impact that the CRISPR/Cas9 system has had on the field. In its natural environment, it functions as an adaptive bacterial immune system that can remember past viral infections. However, it is mainly known and popular as a highly versatile and precise tool for gene editing.... At the heart of the system is Cas9, a programmable and sequence‐specific endonuclease that introduces double‐strand breaks into DNA, which can be exploited to modify the DNA sequence in many different ways. The Cas9 cleavage site is determined by a small RNA molecule, termed guide RNA(gRNA), that base pairs with the target DNA and at the same time binds to Cas9 to initiate the site‐specific double‐strand break... 5, record 3, English, - guide%20ribonucleic%20acid
Record 3, French
Record 3, Domaine(s)
- Génétique
Record 3, Main entry term, French
- acide ribonucléique guide
1, record 3, French, acide%20ribonucl%C3%A9ique%20guide
correct, masculine noun
Record 3, Abbreviations, French
- ARNg 1, record 3, French, ARNg
correct, masculine noun
Record 3, Synonyms, French
- ARN guide 2, record 3, French, ARN%20guide
correct, masculine noun
- ARNg 3, record 3, French, ARNg
correct, masculine noun
- ARNg 3, record 3, French, ARNg
Record 3, Textual support, French
Record number: 3, Textual support number: 1 DEF
ARN s'associant à une enzyme ou à un complexe protéique, qui, lorsqu'il s'apparie à une séquence d'ARN ou d'ADN complémentaire, permet à l'enzyme ou au complexe protéique de se positionner sur cet ARN ou ADN complémentaire. 4, record 3, French, - acide%20ribonucl%C3%A9ique%20guide
Record number: 3, Textual support number: 1 OBS
ARN guide : désignation et définition publiées au Journal officiel de la République française le 28 mars 2018. 5, record 3, French, - acide%20ribonucl%C3%A9ique%20guide
Record 3, Spanish
Record 3, Textual support, Spanish
Record 4 - internal organization data 2026-01-07
Record 4, English
Record 4, Subject field(s)
- Genetics
Record 4, Main entry term, English
- protospacer
1, record 4, English, protospacer
correct, noun
Record 4, Abbreviations, English
Record 4, Synonyms, English
Record 4, Textual support, English
Record number: 4, Textual support number: 1 CONT
In bacteria and archaea, CRISPR–Cas(clustered regularly interspaced short palindromic repeats and CRISPR-associated genes) systems provide RNA-guided [ribonucleic acid-guided] adaptive immunity againstinvaders such as viruses and plasmids... CRISPR–Cas systems are diverse... In all... CRISPR–Cas systems, adaptive immunity consists of three stages : adaptation to novel invaders, CRISPRRNA(crRNA) biogenesis, and invader silencing. During adaptation, short fragments of DNA called "protospacers" are recognized and excised from invader DNA and then processed and integrated into CRISPR arrays(where the same sequences are called "spacers") for use in future invader silencing. 2, record 4, English, - protospacer
Record 4, Key term(s)
- proto-spacer
Record 4, French
Record 4, Domaine(s)
- Génétique
Record 4, Main entry term, French
- proto-espaceur
1, record 4, French, proto%2Despaceur
correct, masculine noun
Record 4, Abbreviations, French
Record 4, Synonyms, French
- protoespaceur 2, record 4, French, protoespaceur
correct, masculine noun
Record 4, Textual support, French
Record number: 4, Textual support number: 1 DEF
Séquence d'ADN de phage ou de plasmide invasifs qui, chez les procaryotes pourvus de groupements d'éléments palindromiques et d'espaceurs, comporte un motif de reconnaissance et la séquence qui deviendra l'espaceur. 1, record 4, French, - proto%2Despaceur
Record number: 4, Textual support number: 1 OBS
proto-espaceur : désignation et définition publiées au Journal officiel de la République française le 28 mars 2018. 3, record 4, French, - proto%2Despaceur
Record 4, Spanish
Record 4, Textual support, Spanish
Record 5 - internal organization data 2025-11-26
Record 5, English
Record 5, Subject field(s)
- Plant Breeding
- Genetics
Record 5, Main entry term, English
- new plant-breeding technique
1, record 5, English, new%20plant%2Dbreeding%20technique
correct, noun
Record 5, Abbreviations, English
- NPBT 2, record 5, English, NPBT
correct, noun
- NBT 3, record 5, English, NBT
correct, noun
Record 5, Synonyms, English
- new plant breeding technique 4, record 5, English, new%20plant%20breeding%20technique
correct, noun
- NPBT 5, record 5, English, NPBT
correct, noun
- NBT 6, record 5, English, NBT
noun
- NPBT 5, record 5, English, NPBT
- new breeding technique 7, record 5, English, new%20breeding%20technique
noun
- NBT 7, record 5, English, NBT
noun
- NBT 7, record 5, English, NBT
Record 5, Textual support, English
Record number: 5, Textual support number: 1 CONT
New plant-breeding techniques... are methods allowing the development of new plant varieties with desired traits, by modifying the DNA of seeds and plant cells.... Based on assessments of the European Commission, the following plant-breeding techniques can currently be considered as the main [techniques] 1) site-directed nucleases(SDN)(including ZFN-1/2/3 and CRISPR [clustered regularly interspaced short palindromic repeat] systems) ;2) oligonucleotide directed mutagenesis(ODM) ;3) cisgenesis; 4) RNA-dependent [ribonucleic acid-dependent] DNA methylation(RdDM) ;5) Grafting(non-GM [genetically modified] scion on GM rootstock) ;6) reverse breeding; [and] 7) agro-infiltration. 3, record 5, English, - new%20plant%2Dbreeding%20technique
Record number: 5, Textual support number: 1 OBS
new plant-breeding technique; new plant breeding technique; new breeding technique; NPBT; NBT: designations usually used in the plural. 8, record 5, English, - new%20plant%2Dbreeding%20technique
Record 5, Key term(s)
- new plant-breeding techniques
- new plant breeding techniques
- new breeding techniques
- NPBTs
- NBTs
Record 5, French
Record 5, Domaine(s)
- Amélioration végétale
- Génétique
Record 5, Main entry term, French
- nouvelle technique de sélection des plantes
1, record 5, French, nouvelle%20technique%20de%20s%C3%A9lection%20des%20plantes
correct, feminine noun
Record 5, Abbreviations, French
Record 5, Synonyms, French
- nouvelle technique de sélection végétale 2, record 5, French, nouvelle%20technique%20de%20s%C3%A9lection%20v%C3%A9g%C3%A9tale
correct, feminine noun
- nouvelle technique d'amélioration des plantes 3, record 5, French, nouvelle%20technique%20d%27am%C3%A9lioration%20des%20plantes
correct, feminine noun
- nouvelle technique de sélection génomique 4, record 5, French, nouvelle%20technique%20de%20s%C3%A9lection%20g%C3%A9nomique
feminine noun
Record 5, Textual support, French
Record number: 5, Textual support number: 1 CONT
L'expression [...] «nouvelles techniques d'amélioration des plantes» [...] recouvre un certain nombre de biotechnologies appliquées au végétal qui ont été développées depuis la fin des années 1990 sur la base de techniques préexistantes. [...] Très diverses, ces techniques peuvent néanmoins être regroupées en plusieurs catégories. Il s'agit : des techniques d'édition du génome qui rassemblent la mutation ciblée par nucléases dirigées ([...] «zinc finger nucleases» (ZFN), méganucléases (MN), TALEN [transcription activator-like effector nucleases], [clustered regularly interspaced short palindromic repeat] CRISPR-Cas) et la mutation dirigée par oligonucléotides (ODM)[;] des techniques d'intégration ciblée d'une séquence d'ADN [acide désoxyribonucléique] par nucléases dirigées[;] des techniques exploitant les mécanismes épigénétiques qui modulent l'expression des gènes : «RNA-dependent DNA methylation» (RdDM)[;] et d'autres techniques [:] agroinfiltration, greffe végétale, cisgenèse et intragenèse, ségrégants négatifs… 3, record 5, French, - nouvelle%20technique%20de%20s%C3%A9lection%20des%20plantes
Record number: 5, Textual support number: 1 OBS
nouvelle technique de sélection des plantes; nouvelle technique de sélection végétale; nouvelle technique d'amélioration des plantes; nouvelle technique de sélection génomique : désignations habituellement utilisées au pluriel. 5, record 5, French, - nouvelle%20technique%20de%20s%C3%A9lection%20des%20plantes
Record 5, Key term(s)
- nouvelles techniques de sélection des plantes
- nouvelles techniques de sélection végétale
- nouvelles techniques d'amélioration des plantes
- nouvelles techniques de sélection génomique
Record 5, Spanish
Record 5, Textual support, Spanish
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