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FRAGMENT ANTIGEN BINDING [2 records]

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Alphabetical list of terms

Record 1 2014-07-14

English

Subject field(s)
  • Immunology
CONT

To combat pathogens that replicate outside cells, antibodies bind to pathogens to link them together, causing them to agglutinate. Since an antibody has at least two paratopes, it can bind more than one antigen by binding identical epitopes carried on the surfaces of these antigens. By coating the pathogen, antibodies stimulate effector functions against the pathogen in cells that recognize their Fc [fragment crystalizable] region.

French

Domaine(s)
  • Immunologie
CONT

Souvent, la liaison de l’anticorps à l’antigène ne conduit à aucun effet biologique direct. Les effets biologiques importants des anticorps sont plutôt la conséquence de fonctions effectrices secondaires. Les immunoglobulines possèdent des fonctions effectrices variées. En général, pour qu’une fonction effectrice soit mise en œuvre, il faut que l’anticorps se lie à l’antigène. Les immunoglobulines ne présentent pas toutes l’ensemble des fonctions effectrices.

CONT

Le mode exact par lequel les anticorps neutralisent et détruisent les cellules cancéreuses est encore imparfaitement compris. Il est cependant clair que trois mécanismes entrent en jeu : l'induction de la mort cellulaire (apoptose), la cytotoxicité dépendant des anticorps (CDA) et la cytotoxicité dépendant du complément (CDC), appelées collectivement les fonctions effectrices.

Spanish

Save record 1

Record 2 1979-03-23

English

Subject field(s)
  • Genetics
CONT

Pooled rabbit IgG [immunoglobulin gamma] digested with papain results in two major fragments. One of the fragments is present in twice the yield of the other, contains the light chain, and is able to bind univalently to antigen. This is called the Fab, for "fragment, antigen binding".

Key term(s)
  • fragment, antigen binding
  • antigen binding fragment

French

Domaine(s)
  • Génétique
DEF

Fragment d'immunoglobuline ne possédant qu'un seul site d'attachement pour antigène.

CONT

Ces fragments dénommés Fab ("fragment antigen binding") correspondent à l'un des bras des molécules complètes d'immunoglobulines.

Spanish

Save record 2

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