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Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 CONT

Once the long and medium-length transcripts reach the cytoplasm, the cell' s protein-making machinery begins constructing the components for new virions. The viral gene called gag encodes the core proteins; pol encodes the reverse transcriptase, protease, integrase and ribonuclease; and env encodes the two envelope proteins.  1, record 1, English, - protein%2Dmaking%20machinery

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 CONT

Lorsque les séquences d'ARN viral longues et moyennes ont migré dans le cytoplasme, la machinerie de synthèse des protéines de la cellule hôte produit les différents constituants des nouveaux virions. Le gène viral gag code les protéines de la nucléocapside; le gène pol code les enzymes transcriptase inverse, protéase, intégrase et ribonucléase, et le gène env code les protéines gpl20 et gp41 de l'enveloppe.  1, record 1, French, - machinerie%20de%20synth%C3%A8se%20de%20prot%C3%A9ines

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 CONT

The human immunodeficiency virus(HIV) genome encodes at least seven groups of viral proteins. These groups of proteins include the three classes of polypeptides present in the majority of animal retroviruses : 1. structural, nonenvelope polypeptides encoded by the gag gene; 2. enzymes required for virion replication(reverse transcriptase/r) and for cleavage of viral precursor proteins(protease/pr), both encoded by the pol gene; 3. envelope polypeptides encoded by env gene. In addition, HIV's possess genes that encode four sets of polypeptides not found in the majority of typical retroviruses. These include a transactivating regulator of RNA translation(tat), a cis-acting downregulator of RNA transcription(nef), a regulator that modulates the expression of structural proteins(rev), a protein that modulates viral infectivity(vif), and two proteins(vpr, vpu) whose functions are still unclear. [From source a].  2, record 2, English, - viral%20protein

Record number: 2, Textual support number: 1 OBS

Both the core and envelope of HIV are composed of viral proteins. The core viral proteins include p24 and p18, and the envelope viral proteins include gp41 and gp120.  3, record 2, English, - viral%20protein

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 CONT

Protéines virales. Les protéines du V.I.H.-1, toutes antigéniques, c'est-à-dire capables d'induire la production d'anticorps, se répartissent en : 1) Des protéines associées à la nucléocapside. Ce sont des protéines structurales internes liées aux unités d'ARN et formant avec elle la nucléoïde. 2) Des protéines d'enveloppes chargées de sucres (glycoprotéines) 3) De nombreuses autres protéines identifiées récemment et dont le rôle commence à être connu.  2, record 2, French, - prot%C3%A9ine%20virale

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 DEF

A core protein of HIV produced by the gag gene.  2, record 3, English, - p24%20antigen

Record number: 3, Textual support number: 1 OBS

A protein specific to HIV, which is an indirect measure of how quickly the virus is replicating, or making new viruses.  3, record 3, English, - p24%20antigen

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 OBS

Ce qui distingue le sida des autres épidémies, c'est la très longue période d'incubation qui, en moyenne, est d'une dizaine d'années. Tout au long de cette période, il y a peu de réplication virale dans le sang périphérique et le décompte des lymphocytes CD4 demeure légèrement abaissé. Par contre la réplication virale se poursuit dans les tissus lymphoïdes. L'antigène p24 est souvent absent mais les anticorps anti-VIH demeurent décelables.  2, record 3, French, - antig%C3%A8ne%20p24

Record 3,  Textual support,  Spanish

Record number: 3, Textual support number: 1 CONT

Los niveles del antígeno 24 en la sangre se usan para monitorear la actividad viral. Los niveles altos sugieren que el VIH se está replicando y los niveles bajos [indican] que se encuentra en estado de latencia. Sin embargo, no se considera un método exacto porque la existencia de anticuerpos p24 puede hacer que esta partícula viral sea indetectable.  1, record 3, Spanish, - ant%C3%ADgeno%20p24

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 CONT

HIV is composed of a single positive strand of RNA that is 9300 nucleotide bases in length, along with viral genetic segments encoding both structural and regulatory proteins. One of them, the gag gene, encodes the major internal viral structural proteins p17, p24, p15.  2, record 4, English, - gag%20gene

Record number: 4, Textual support number: 1 OBS

gag: group antigen (core protein).  3, record 4, English, - gag%20gene

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 CONT

Les gènes du V.I.H.-1 comportent les trois gènes structuraux fondamentaux des rétrovirus, présents à la fois dans les cellules infectées et dans les particules virales matures. Le gène gag (ce qui signifie gène de l'antigène de groupe) qui code pour les protéines de nucléotide.  2, record 4, French, - g%C3%A8ne%20gag

Record 4,  Textual support,  Spanish

Record number: 4, Textual support number: 1 DEF

Gen característico de los retrovirus, que contiene la información para que se formen las proteínas de su núcleo o corazón.  1, record 4, Spanish, - gen%20gag

Record 5,  Textual support,  English

Record number: 5, Textual support number: 1 CONT

Treated with these two genomes, the packaging cell produces a crop of retroviruses with : the envelope protein needed to infect the human target cells; an RNA copy of the human ADA [adenosine deaminase] gene, complete with R sequences at each end; reverse transcriptase, needed to make a DNA copy of the ADA gene that can be inserted into the DNA of the target cell and none of the genes(gag, pol, env) that would enable the virus to replicate in its new host.  3, record 5, English, - packaging%20cell

Record number: 5, Textual support number: 2 CONT

To create the retroviral vectors that are used in gene therapy, the life-cycles of their naturally occurring counterparts are exploited. The transgene (in this case, the gene for factor IX) in a vector backbone is put into a packaging cell, which expresses the genes that are required for viral integration.  4, record 5, English, - packaging%20cell

Record 5,  Textual support,  French

Record number: 5, Textual support number: 1 CONT

Les différents modes de transfert sont : [...] Injection de cellules produisant le vecteur viral pour éviter son inactivation trop rapide par le complément. Ces cellules sont appelés cellules transcomplémentantes (ou cellules d'encapsidation).  3, record 5, French, - cellule%20d%27encapsidation

Record number: 5, Textual support number: 1 OBS

Il s'agit d'un type de cellules utilisées pour produire des virus non pathogènes en supprimant les gènes nécessaires à leur réplication et en les remplaçant par une séquence choisie et des éléments régulateurs.  4, record 5, French, - cellule%20d%27encapsidation

Record 5,  Textual support,  Spanish

Record 6,  Textual support,  English

Record number: 6, Textual support number: 1 DEF

Sequence found within the structural genes of HIV-1 and of other complex retroviruses. Multiple INS elements exist within the genome and can act independently; one of the best characterized elements spans nucleotides 414 to 631 in the gag region of HIV-1. The INS elements have been defined by functional assays as elements that inhibit expression posttranscriptionally. Mutation of the RNA elements was shown to lead to INS inactivation and up regulation of gene expression.  1, record 6, English, - inhibitory%20RNA%20sequence

Record number: 6, Textual support number: 1 OBS

In plural in the text.  2, record 6, English, - inhibitory%20RNA%20sequence

Record number: 6, Textual support number: 2 OBS

Glossary in molecular biology (Portions of the glossary text were taken directly or modified from definitions in the U.S. Congress Office of Technology Assessment document).  2, record 6, English, - inhibitory%20RNA%20sequence

Record 6,  Textual support,  French

Record 6,  Textual support,  Spanish