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Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 DEF

A drug used in the treatment of parasite germs, especially against Pneumocytis carinii pneumonia (PCP), an opportunistic disease that people living with AIDS may get.  3, record 1, English, - eflornithine%20hydrochloride

Record number: 1, Textual support number: 1 OBS

It may alleviate some of the symptoms of cryptosporidiosis. In vitro studies suggests that DFMO(Eflornithine) has a synergistic effect with ganciclovir, implying that lower, less toxic doses might be possible in the future to control retinitis.  2, record 1, English, - eflornithine%20hydrochloride

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 CONT

L'eflornithine hydrochloride (inhibiteur de l'ornithine décarboxylase) est utilisé dans le traitement de la pneumonie à Pneumocystis carinii.  2, record 1, French, - eflornithine%20hydrochloride

Record 1,  Textual support,  Spanish

Record number: 1, Textual support number: 1 OBS

Agente inhibidor de la síntesis de poliamina. Ha sido estudiado en humanos como tratamiento [contra] la neumonía por Pneumocystis carinii. La toxicidad incluye supresión de la médula ósea y flebitis en el sitio de la inyección.  1, record 1, Spanish, - eflorentina

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 CONT

An acyclovir analog that is a potent inhibitor of the Herpes virus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.  2, record 2, English, - gancyclovir

Record number: 2, Textual support number: 1 OBS

Chemical formula: C₉H₁₃N₅O₄  3, record 2, English, - gancyclovir

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 OBS

Formule chimique : C₉H₁₃N₅O₄  2, record 2, French, - gancyclovir

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 CONT

In another application of gene therapy we have used an adenoviral vector that carries the gene for herpes simplex virus thymidine kinase(HSV-tk). Cells expressing HSV-tk will convert the anti-viral drug ganciclovir(GCV) to a form that is toxic to rapidly dividing cells. Using this adenoviral vector we have repeatedly shown robust tumoricidal effects in a variety of animal models of CNS tumor and will soon take this treatment to phase I clinical trials. We are extending this work to the manipulation of the CNSs immune response to tumors using adenoviral vectors that carry several cytokine genes.  1, record 3, English, - herpes%20simplex%20virus%20thymidine%20kinase

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 CONT

Traitement du glioblastome multiforme - une tumeur létale du cerveau - par transduction tumorale in vivo du gène codant la thymidine kinase du virus herpès simplex (HSV-TK), suivie par l'administration de ganciclovir, tel est l'intitulé des essais cliniques de phase II qui ont débuté en juin dernier en Belgique.  1, record 3, French, - thimidine%20kinase%20du%20virus%20herp%C3%A8s%20simplex

Record 3,  Textual support,  Spanish

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 CONT

Recent media reports have painted a relentlessly gloomy picture of the status of AIDS drug development. Yet much useful information on treatment emerged at the 10th International Conference on AIDS in Yokohama, Japan(August 7-12, 1994). Encouraging treatment developments presented in Yokohama include the following : Recombinant human growth hormone therapy significantly increases weight gain as represented by fat-free lean body mass among people with AIDS-related wasting. AZT treatment dramatically reduces the rate of HIV transmission from mother to infant. Acyclovir co-treatment with anti-HIV therapy significantly increases survival time among people with AIDS. Oral ganciclovir appears to be an effective primary prophylaxis for cytomegalovirus disease. The protease inhibitor drug saquinavir reduces viral load and increases CD4 cell counts significantly more when used in a triple combination with AZT and ddC compared to 2 double combinations(AZT plus ddC or saquinavir plus AZT). Quantitative polymerase chain reaction(PCR) and branched chain DNA(bDNA) testing for measuring HIV load is expected to become a major new tool to help guide individual treatment decisions and to evaluate anti-HIV therapies in clinical studies.  1, record 4, English, - AIDS%20drug

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 CONT

Chaque étape du cycle de réplication du virus est la cible potentielle d'un médicament contre le sida.  1, record 4, French, - m%C3%A9dicament%20contre%20le%20sida

Record number: 4, Textual support number: 2 CONT

[...] l'azidothymidine ou AZT constitue sans aucun doute le plus connu des médicaments du sida.  2, record 4, French, - m%C3%A9dicament%20contre%20le%20sida

Record 4,  Textual support,  Spanish

Record number: 4, Textual support number: 1 OBS

Las siglas del síndrome de inmunodeficiencia adquirida (sida) se han incorporado al español como un nombre común, por lo cual se escriben en minúsculas.  2, record 4, Spanish, - medicamento%20contra%20el%20sida

Record 5,  Textual support,  English

Record number: 5, Textual support number: 1 DEF

A hormone that stimulates production of both granulocytes and macrophages  3, record 5, English, - granulocyte%2Dmacrophage%20colony%20stimulating%20factor

Record number: 5, Textual support number: 1 OBS

Recombinant GM-CSF is under development as a means of alleviating the neutropenia caused by AZT and ganciclovir.  3, record 5, English, - granulocyte%2Dmacrophage%20colony%20stimulating%20factor

Record 5,  Textual support,  French

Record number: 5, Textual support number: 1 CONT

Étude de la différenciation, survie et prolifération cellulaires dans le système hématopoïétique : 1) analyse du récepteur du facteur de croissance hématopoïétique GM-CSF (facteur de stimulation des granulocytes et macrophages); étude de structure-fonction; signalisation.  1, record 5, French, - facteur%20de%20stimulation%20des%20granulocytes%20et%20macrophages

Record 5,  Textual support,  Spanish

Record number: 5, Textual support number: 1 DEF

Citocina que estimula el crecimiento de los granulocitos y macrófagos. Al igual que el factor estimulante de las colonias de granulocitos (G-CSF), este factor alivia la neutropenia, pero es menos específico y tiene más efectos secundarios que el G-CSF [...]  1, record 5, Spanish, - factor%20estimulante%20de%20las%20colonias%20de%20granulocitos%20y%20macr%C3%B3fagos

Record 6,  Textual support,  English

Record number: 6, Textual support number: 1 CONT

... according to Ashok Srinivasan, a paediatric oncologist at UCLA, the tk gene has already been grafted into the neurons of children suffering from brain tumours, with the aim of making these aggressive tumours susceptible to treatment with large doses of ganciclovir, a close relative of acyclovir.  1, record 6, English, - paediatric%20oncologist

Record 6,  Textual support,  French

Record 6,  Textual support,  Spanish

Record 7,  Textual support,  English

Record number: 7, Textual support number: 1 CONT

The intraocular ganciclovir implant was approved for induction and maintenance therapy of CMV retinitis with a median time to retinitis progression greater than 200 days.  1, record 7, English, - CMV%20retinitis

Record number: 7, Textual support number: 2 CONT

Combination Foscarnet and Ganciclovir Therapy vs Monotherapy for the Treatment of Relapsed Cytomegalovirus Retinitis in Patients With AIDS  2, record 7, English, - CMV%20retinitis

Record 7,  Textual support,  French

Record number: 7, Textual support number: 1 DEF

[...] grave infection associée [au sida], qui nécessite une perfusion quotidienne à l'hôpital.  1, record 7, French, - r%C3%A9tinite%20%C3%A0%20cytom%C3%A9galovirus

Record 7,  Textual support,  Spanish