TERMIUM Plus®
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GCV [1 record]
Record 1 - internal organization data 2010-04-20
Record 1, English
Record 1, Subject field(s)
- Biochemistry
- Genetics
Record 1, Main entry term, English
- herpes simplex virus thymidine kinase
1, record 1, English, herpes%20simplex%20virus%20thymidine%20kinase
correct
Record 1, Abbreviations, English
- HSV-TK 2, record 1, English, HSV%2DTK
correct
- HSV-tk 1, record 1, English, HSV%2Dtk
correct
Record 1, Synonyms, English
Record 1, Textual support, English
Record number: 1, Textual support number: 1 CONT
In another application of gene therapy we have used an adenoviral vector that carries the gene for herpes simplex virus thymidine kinase(HSV-tk). Cells expressing HSV-tk will convert the anti-viral drug ganciclovir(GCV) to a form that is toxic to rapidly dividing cells. Using this adenoviral vector we have repeatedly shown robust tumoricidal effects in a variety of animal models of CNS tumor and will soon take this treatment to phase I clinical trials. We are extending this work to the manipulation of the CNSs immune response to tumors using adenoviral vectors that carry several cytokine genes. 1, record 1, English, - herpes%20simplex%20virus%20thymidine%20kinase
Record 1, French
Record 1, Domaine(s)
- Biochimie
- Génétique
Record 1, Main entry term, French
- thimidine kinase du virus herpès simplex
1, record 1, French, thimidine%20kinase%20du%20virus%20herp%C3%A8s%20simplex
correct, feminine noun
Record 1, Abbreviations, French
- HSV-TK 2, record 1, French, HSV%2DTK
correct, feminine noun
Record 1, Synonyms, French
Record 1, Textual support, French
Record number: 1, Textual support number: 1 CONT
Traitement du glioblastome multiforme - une tumeur létale du cerveau - par transduction tumorale in vivo du gène codant la thymidine kinase du virus herpès simplex (HSV-TK), suivie par l'administration de ganciclovir, tel est l'intitulé des essais cliniques de phase II qui ont débuté en juin dernier en Belgique. 1, record 1, French, - thimidine%20kinase%20du%20virus%20herp%C3%A8s%20simplex
Record 1, Spanish
Record 1, Textual support, Spanish
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