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GDNF [2 records]

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Alphabetical list of terms

Record 1 2001-10-18

English

Subject field(s)
  • Biochemistry
CONT

GDNF increases motoneuron survival and cell number, neurite outgrowth and choline acethyltransferase(ChAT) activity(Henderson et al., 1994). The motoneurons can also be rescued from axotomy-induced or natural cell death by GDNF in mouse, rat and avian models(Henderson et al., 1994; Oppenheim et al., 1995). This response is not limited to developing motor neurons, but is also seen in the neurons of adult animals(Li et al., 1995; Yan et al., 1995) supporting the idea of the applicability of GDNF as a potential therapeutic agent in motor neuron diseases, such as amyotrophic lateral sclerosis(ALS), spinal muscular atrophy or in ischemic and mechanic injuries of the spinal cord.

French

Domaine(s)
  • Biochimie
CONT

La choline acéthyltransférase (ChAT) catalyse la biosynthèse du neurotransmetteur acétylcholine. Outre sa forme soluble, hydrophile, nous avons démontré l'existence d'une forme membranaire, amphiphile, de la ChAT dans la tête de Drosophile. Les taux d'enzyme membranaire augmentent au cours du développement.

Spanish

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Record 2 2001-06-06

English

Subject field(s)
  • Biological Sciences
CONT

Human GDNF(glial derived Neurotrophic Factor) is a 30. 1kDa protein that specifically promotes dopamine uptake and survival of midbrain neurons. GDNF is a disulphide linked homodimeric protein consisting of two 134 amino acid chains.

French

Domaine(s)
  • Sciences biologiques
OBS

Facteur neurotrophique ayant une application thérapeutique potentielle dans les cas de maladie de Parkinson.

Spanish

Save record 2

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