TERMIUM Plus^®

Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 DEF

A protein produced by the nef gene.  3, record 1, English, - nef%20protein

Record number: 1, Textual support number: 1 CONT

A regulatory gene expressed in the early phase [of HIV infection] is called nef. Until quite recently, it was believed that nef's role was to suppress transcription, but new experiments have cast doubt on that interpretation. Nef protein may somehow modify the cell to make it more suitable for manufacturing HIV virions later. In any event, it now appears that production of nef protein is required for the development of AIDS, a finding that could be important if a way can be found to block its action.  4, record 1, English, - nef%20protein

Record number: 1, Textual support number: 1 OBS

nef: negative factor.  5, record 1, English, - nef%20protein

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 CONT

La protéine nef ou p27, anciennement désignée par p27-3'orf, produite par le gène nef, n'est pas retrouvée dans le virus mais dans les cellules infectées, exerce un effet inhibiteur (régulateur négatif) mais couplée à d'autres systèmes de régulation; elle agirait au niveau de la LTR sur une zone de régulation négative (NRE ou negative regulatory element); nef jouerait plus un rôle d'anti-activateur que de répression du V.I.H. L'absence de production de protéine nef serait corrélée avec l'augmentation de la cythogénécité in vitro.  3, record 1, French, - prot%C3%A9ine%20nef

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 CONT

Like the Lee group, the Lemke team also used a mouse model system; genetically engineered mice lacking the erbB4 gene displayed a number of defects in the organization, spacing, and patterning of connections among neurons in the brain and central nervous system. The nature of these defects also provided the first evidence of chemorepulsion-an inhibitory block to the formation of connections-among brain cells as a regulatory mechanism in vertebrates.  2, record 2, English, - chemorepulsion

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 CONT

Chimio-attraction ou chimio-répulsion. À la fin de leur phase proliférative, les neurones postmitotiques migrent le long des axes gliaux, répondant à des indices positionnels qui permettent la localisation précise de leur corps cellulaire (ou soma).  1, record 2, French, - chimio%2Dr%C3%A9pulsion

Record 2,  Textual support,  Spanish