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GENE CLUSTER [3 records]

Record 1 2020-09-24

English

Subject field(s)
  • Genetics
CONT

... using gene cluster analysis, [researchers] observed heterogeneity in genetic expression profiles among cancers of a particular histopathological grade.

French

Domaine(s)
  • Génétique
CONT

Les protéines de liaison à l'ARN [acide ribonucléique], dites RBP [protéine de liaison du rétinol], jouent un rôle important dans la régulation de l'expression des gènes [...] les RBP sont presque toujours situés dans un sous-compartiment cellulaire, ce qui suggère qu'ils jouent un rôle actif dans la régulation des ARN [...] Certains pourraient, par exemple, avoir pour fonction de transporter des ARN vers des emplacements spécifiques de la cellule. D'autres peuvent réagir rapidement au stress externe, modifiant la distribution d'ARN dans la cellule et modifiant le profil d'expression génique.

Spanish

Save record 1

Record 2 2004-12-02

English

Subject field(s)
  • Genetics
DEF

A gene that contains a homeobox, a DNA sequence that determines the development of limbs and other body parts in an embryon.

CONT

A particular subgroup of homeobox genes are the Hox genes, which are found in a special gene cluster, the HOX cluster. Hox genes function in patterning the body axis. Thus, by providing the identity of particular body regions, Hox genes determine where limbs and other body segments will grow in a developing fetus or larva.

Key term(s)
  • HOX gene

French

Domaine(s)
  • Génétique
CONT

Parmi les structures dont le développement correct pourrait dépendre de l'expression coordonnée des gènes HOX se trouvent les membres. En effet, le gène Hox-5.2 est très fortement exprimé dans les ébauches des membres chez l'embryon de neuf jours.

OBS

Une classification numérique à l'exemple de gène Hox-1.2 renvoie au second gène isolé en tant que membre de l'homéobox de critère 1...

OBS

Les gènes Hox font partie d'une classe particulière de gènes à homéoboîtes.

Key term(s)
  • gène HOX

Spanish

Save record 2

Record 3 2004-07-12

English

Subject field(s)
  • Statistical Graphs and Diagrams
  • Information Theory
CONT

Nevertheless, clustering real-world data sets often raises problems, since the data space is usually a high dimensional feature space. A prominent example is the application of cluster analysis to gene expression data.... In general, most of the common clustering algorithms fail to generate meaningful results because of the inherent sparsity of the data space. In such high dimensional feature spaces data does not cluster anymore.

OBS

The modern world is full of large data sets: census data, multimedia databases, and remote sensing data, to name a few. With the aid of computers it is possible to collect scientific data on a grand scale. These examples are not "large" merely because they have many data points. They are also high dimensional, meaning that there are many measurements taken of each person, multimedia object, or point on the ground. The "data point" representing one person is made up of their age, gender, educational level, occupation, and whatever else was recorded. Suppose there are 12 attributes recorded for each person. We can think of that person’s record as a point in 12 dimensional space.

French

Domaine(s)
  • Diagrammes et graphiques (Statistique)
  • Théorie de l'information

Spanish

Save record 3

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