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Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 CONT

Mouse P0 gene disruption leads to hypomyelination, abnormal expression of recognition molecules, and degeneration of myelin and axons.  2, record 1, English, - gene%20disruption

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 DEF

Interruption de la séquence codante d'un gène par introduction d'une autre séquence d'ADN.  1, record 1, French, - disruption%20g%C3%A9nique

Record 1,  Textual support,  Spanish

Record number: 1, Textual support number: 1 CONT

Generación de mutantes de levadura por interrupción génica. La integración de un fragmento de ADN dentro de un gen se logra utilizando un plásmido linearizado con una enzima de restricción. Dado que las moléculas lineales son substratos recombinogénicos (que recombinan frecuentemente), éstas se integran preferencialmente dentro de la secuencia cromosómica homóloga a la que se encuentra en los extremos del plásmido linearizado.  1, record 1, Spanish, - interrupci%C3%B3n%20g%C3%A9nica

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 CONT

The development of influenza virus-specific CD8+ cytotoxic T lymphocyte precursors(CTLp) is diminished in H-2b mice that are homozygous(-/-) for disruption of the H-2IA b gene. Virus clearance was not obviously delayed when compared with the congenic H-2IAb(+/+) controls, and evidence of CTL activity was apparent for inflammatory cells recovered from the respiratory tract in both cases. However, the virus-specific CTLp that are normally present in the regional lymph nodes and in the infected lung were evidently being consumed at the peak of the host response to give the terminally differentiated CTL effectors.  1, record 2, English, - cytotoxic%20T%20lymphocyte%20precursor

Record 2,  Textual support,  French

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 CONT

The scale of the gene disruption experiments we are carrying out--inactivating more than 25% of all vital genes--is unprecedented in multicellular organisms, and is likely to provide unique insights into the organization of eukaryotic genomes.  2, record 3, English, - gene%20disruption

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 DEF

Détection de gènes d'un organisme par hybridation de son génome avec des sondes moléculaires spécifiques.  1, record 3, French, - disruption%20g%C3%A9nique

Record number: 3, Textual support number: 1 OBS

Cette méthode est utilisée par exemple pour le diagnostic prénatal de certaines maladies héréditaires ou pour la détermination parentale.  1, record 3, French, - disruption%20g%C3%A9nique

Record 3,  Textual support,  Spanish