TERMIUM Plus^®

Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 CONT

TALENs are a chimera of transcription activator-like effectors (TALEs) and restriction enzymes, predominantly Fok1 nuclease. The TALE proteins act as programmable DNA search engines while the Fok1 are the molecular scissors cutting the DNA target site.  4, record 1, English, - transcription%20activator%2Dlike%20effector%20nuclease

Record number: 1, Textual support number: 2 CONT

Transcription activator-like effector nucleases(TALENs) are restriction enzymes that bind to DNA based on its specificity and can be tailored to cut sequences of DNA. They are made by combining TAL [transcription activator-like] binding domains, which allows entry into a cell, and a DNA cleavage domain, which is helpful in gene editing. These can be tailored to bind to any targeted area in the genome to cut any desired specific location.  5, record 1, English, - transcription%20activator%2Dlike%20effector%20nuclease

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 CONT

Les nucléases TALEN dérivent de la molécule «transcription activator-like effectors» (TALE) [...] Les TALEN sont composées d'un domaine de reconnaissance de l'ADN TALE fusionné avec la nucléase Fok1.  2, record 1, French, - nucl%C3%A9ase%20effectrice%20de%20type%20activateur%20de%20transcription

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 CONT

Guide RNAs (gRNAs) are tiny RNA [ribonucleic acid] transcripts that guide the editing machinery through base-pairing with the mRNAs [messenger ribonucleic acids] in edited regions. gRNAs are complementary to small segments of the fully edited mRNAs, and thus serve as mini-templates to guide the addition and deletion of Us from the pre-edited mRNA as they form a locally double-stranded RNA helix.  4, record 2, English, - guide%20ribonucleic%20acid

Record number: 2, Textual support number: 2 CONT

No one studying molecular biology can escape the impact that the CRISPR/Cas9 system has had on the field. In its natural environment, it functions as an adaptive bacterial immune system that can remember past viral infections. However, it is mainly known and popular as a highly versatile and precise tool for gene editing.... At the heart of the system is Cas9, a programmable and sequence‐specific endonuclease that introduces double‐strand breaks into DNA, which can be exploited to modify the DNA sequence in many different ways. The Cas9 cleavage site is determined by a small RNA molecule, termed guide RNA(gRNA), that base pairs with the target DNA and at the same time binds to Cas9 to initiate the site‐specific double‐strand break...  5, record 2, English, - guide%20ribonucleic%20acid

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 DEF

ARN s'associant à une enzyme ou à un complexe protéique, qui, lorsqu'il s'apparie à une séquence d'ARN ou d'ADN complémentaire, permet à l'enzyme ou au complexe protéique de se positionner sur cet ARN ou ADN complémentaire.  4, record 2, French, - acide%20ribonucl%C3%A9ique%20guide

Record number: 2, Textual support number: 1 OBS

ARN guide : désignation et définition publiées au Journal officiel de la République française le 28 mars 2018.  5, record 2, French, - acide%20ribonucl%C3%A9ique%20guide

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 CONT

Prime editing ... uses exogenous reverse transcriptase activity to "write" DNA edits directly into genomic DNA ...  3, record 3, English, - prime%20editing

Record number: 3, Textual support number: 2 CONT

Prime editing is [an] innovative gene editing technique that allows for precise modifications to the DNA sequence, including insertions, deletions and substitutions, without the need for double-strand breaks. It combines the functions of a catalytically impaired Cas9 enzyme(nickase) and a reverse transcriptase enzyme, along with a unique RNA [ribonucleic acid] molecule called prime editing guide RNA(pegRNA).  4, record 3, English, - prime%20editing

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 DEF

Réécriture génomique qui consiste à incorporer au génome une séquence d'ADN issue de la transcription inverse in situ d'une matrice d'ARN [acide ribonucléique].  2, record 3, French, - r%C3%A9%C3%A9criture%20par%20matrice%20d%27acide%20ribonucl%C3%A9ique

Record number: 3, Textual support number: 1 OBS

réécriture par matrice d'ARN : désignation et définition publiées au Journal officiel de la République française le 9 avril 2022.  1, record 3, French, - r%C3%A9%C3%A9criture%20par%20matrice%20d%27acide%20ribonucl%C3%A9ique

Record 3,  Textual support,  Spanish

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 CONT

The detection of non-Mendelian inheritance in man. How to detect and interpret variation in gene structure or expression that does not or might not follow a Mendelian mode of inheritance : mitochondrial mutations(particularly when heteroplasmic) ;uniparental disomy(full or regional, heterodisomy, homodisomy, isodisomy, pseudodisomy) ;unstable DNA(including triplet repeat regions) ;imprinting; X chromosome inactivation mutations or effects; positional effects; cis-trans effects, singleton birth after regression of an MZ twin, chimerism, parthenogenesis, aneuploid reproduction and recombination, RNA editing, etc.  1, record 4, English, - heteroplasmic

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 CONT

Chez un enfant né d'un ovule hétéroplasmique, certains tissus sont enrichis en ADN mitochondrial normal, tandis que d'autres sont enrichis en ADN muté.  2, record 4, French, - h%C3%A9t%C3%A9roplasmique

Record 4,  Textual support,  Spanish