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Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 CONT

... the suprachoroidal injection approach delivers the gene therapy payload via the potential space between the sclera and the choroid(suprachoroidal space, or SCS). This is a potentially favored injection site for gene therapy because it may reduce the likelihood of eliciting an immunologic response due to its unique location with respect to the blood-retina barrier while simultaneously permitting adequate gene expression to control the nAMD [neovascular age-related macular degeneration] disease process. Surgical access to the SCS can be facilitated by creation of a sclerotomy, followed by introduction of a catheter or cannula. Separately, and potentially of greater interest, is for suprachoroidal gene therapy to be delivered in the clinic setting by utilizing hypodermic needles or hollow microneedles.  1, record 1, English, - suprachoroidal%20gene%20therapy

Record number: 1, Textual support number: 2 CONT

gene therapy: The treatment of certain medical disorders, especially those caused by genetic anomalies or deficiencies, by introducing specific engineered genes into a patient’s cells.  3, record 1, English, - suprachoroidal%20gene%20therapy

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 OBS

Thérapie qui consiste en l'injection de gènes dans la couche de la choroïde adhérant à la sclère dans le but de traiter une maladie rétinienne.  1, record 1, French, - th%C3%A9rapie%20g%C3%A9nique%20suprachoro%C3%AFdienne

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 CONT

TALENs are a chimera of transcription activator-like effectors (TALEs) and restriction enzymes, predominantly Fok1 nuclease. The TALE proteins act as programmable DNA search engines while the Fok1 are the molecular scissors cutting the DNA target site.  4, record 2, English, - transcription%20activator%2Dlike%20effector%20nuclease

Record number: 2, Textual support number: 2 CONT

Transcription activator-like effector nucleases(TALENs) are restriction enzymes that bind to DNA based on its specificity and can be tailored to cut sequences of DNA. They are made by combining TAL [transcription activator-like] binding domains, which allows entry into a cell, and a DNA cleavage domain, which is helpful in gene editing. These can be tailored to bind to any targeted area in the genome to cut any desired specific location.  5, record 2, English, - transcription%20activator%2Dlike%20effector%20nuclease

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 CONT

Les nucléases TALEN dérivent de la molécule «transcription activator-like effectors» (TALE) [...] Les TALEN sont composées d'un domaine de reconnaissance de l'ADN TALE fusionné avec la nucléase Fok1.  2, record 2, French, - nucl%C3%A9ase%20effectrice%20de%20type%20activateur%20de%20transcription

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 DEF

The linear arrangement of genes along the chromosomes of an organism. It is usually presented graphically, with the location of each gene determined by one or more of a variety of mapping techniques.  3, record 3, English, - chromosome%20map

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 DEF

Représentation linéaire de la position des gènes sur un chromosome.  4, record 3, French, - carte%20chromosomique

Record 3,  Textual support,  Spanish

Record number: 3, Textual support number: 1 DEF

Representación gráfica del ordenamiento espacial de los genes sobre un cromosoma.  3, record 3, Spanish, - mapa%20cromos%C3%B3mico

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 CONT

Since alleles derived from different parental origins that are identical in nucleotide sequence may exhibit imprinting, the differences between the paternal and maternal genetic material are due to differential programming during spermatogenesis or oogenesis. The different packaging constraints of the sperm cell compared with the ovum also may be important. The regulatory mechanisms superimpose on the nucleotide sequence of a gene to determine the location, timing and degree of expression, and are termed epigenetic effects. Epigenetic modification(rather than genetic divergence of the gametes) of the DNA is likely to be the signal that marks the sperm and egg alleles as different. Imprinting is a special type of epigenetic inheritance that is passed through the gene line into somatic tissues of the progeny and is parent-specific.  1, record 4, English, - epigenetic%20modification

Record number: 4, Textual support number: 1 OBS

epigenetic: The absence of factors in the genotype that exerts an effect upon the phenotype.  2, record 4, English, - epigenetic%20modification

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 DEF

Altération chromosomique pouvant être héritée et réversible, qui se surimpose à la séquence nucléotidique.  1, record 4, French, - modification%20%C3%A9pig%C3%A9n%C3%A9tique

Record number: 4, Textual support number: 1 OBS

Le niveau supplémentaire d'information ainsi créé permettrait, par exemple, de distinguer l'origine parentale des chromosomes.  1, record 4, French, - modification%20%C3%A9pig%C3%A9n%C3%A9tique

Record 4,  Textual support,  Spanish

Record 5,  Textual support,  English

Record number: 5, Textual support number: 1 DEF

Individual primary recombinant clones(hosted in phage, cosmid, YAC, or other vector) that are placed in two-dimensional arrays in microtiter dishes. Each primary clone can be identified by the identity of the plate and the clone location(row and column) on that plate. Arrayed libraries of clones can be used for many applications, including screening for a specific gene or genomic region of interest as well as for physical.  1, record 5, English, - arrayed%20library

Record number: 5, Textual support number: 1 OBS

Glossary in molecular biology (Portions of the glossary text were taken directly or modified from definitions in the U.S. Congress Office of Technology Assessment document.  2, record 5, English, - arrayed%20library

Record 5,  Textual support,  French

Record number: 5, Textual support number: 1 OBS

Les clones sont disposés en rangs et en colonnes (grilles) dans une boîte de Pétri. Ce type de banque est différent des banques génomiques où les clones sont dispersés sans ordre dans la boîte de Pétri.  1, record 5, French, - banque%20de%20clones%20dispos%C3%A9s%20en%20grille

Record number: 5, Textual support number: 2 OBS

Proposition faite par un spécialiste en biologie moléculaire à la GRC.  1, record 5, French, - banque%20de%20clones%20dispos%C3%A9s%20en%20grille

Record 5,  Textual support,  Spanish

Record 6,  Textual support,  English

Record number: 6, Textual support number: 1 CONT

The existence of a breast cancer susceptibility gene known as BRCA1 and its approximate location on human chromosome 17 have been known for about four years, based on family studies, but only now have scientists actually isolated, or "cloned, "the gene--pinpointed its exact location and made copies of it in the laboratory. In some families, the gene is inherited in a mutated(altered) form. Women who inherit a mutated form are highly susceptible to breast and ovarian cancers.  1, record 6, English, - susceptibility%20gene

Record 6,  Textual support,  French

Record number: 6, Textual support number: 1 CONT

Deux gènes de prédisposition au cancer du sein, BRCA1 et BRCA2 ont été découverts en 1994 et 1995 et semblent être la cause dans 5% à 10% des cancers du sein. Il faut noter que des gènes de prédisposition au cancer en général peuvent être responsables de cancers familiaux mais leur rôle direct dans cette affection est faible [...]  1, record 6, French, - g%C3%A8ne%20de%20pr%C3%A9disposition

Record 6,  Textual support,  Spanish