TERMIUM Plus^®

Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 DEF

A chip of silicon or other solid material on which microscopic arrays of molecules such as DNA sections or polypeptides are mounted for simultaneous testing or analysis.  6, record 1, English, - DNA%20chip

Record number: 1, Textual support number: 1 CONT

The completion of the sequencing of the human genome and that of many other organisms makes the determination of gene function an important... step in understanding the role of DNA in the processes of life. DNA microarrays are an excellent tool to address this question because their numerous probe sites enable the analysis of many genes simultaneously.  7, record 1, English, - DNA%20chip

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 DEF

Petite plaque de verre, de silicium ou d'un autre matériau inerte, sur laquelle ont été greffés des brins d'ADN [acide désoxyribonucléique] de cellules ou de micro-organismes, permettant d'en révéler spécifiquement la présence dans le milieu en contact avec la plaque.  5, record 1, French, - puce%20%C3%A0%20ADN

Record number: 1, Textual support number: 1 OBS

La lecture de la puce après hydridation avec un ADN marqué par fluorescence donne des informations sur sa séquence.  2, record 1, French, - puce%20%C3%A0%20ADN

Record number: 1, Textual support number: 2 OBS

puce à ADN; biopuce à ADN : termes publiés au Journal officiel de la République française le 6 juillet 2008.  6, record 1, French, - puce%20%C3%A0%20ADN

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 DEF

The determination of the order of bases of a DNA [segment] making up a gene.  2, record 2, English, - gene%20sequencing

Record number: 2, Textual support number: 1 CONT

CF [cystic fibrosis] gene sequencing detects the most common mutations, as well as less common mutations...  3, record 2, English, - gene%20sequencing

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 DEF

Établissement de la séquence des nucléotides d'un segment d'ADN donné constituant un gène.  2, record 2, French, - s%C3%A9quen%C3%A7age%20de%20g%C3%A8ne

Record number: 2, Textual support number: 1 CONT

Apport du séquençage de gène. Le recours au séquençage de gène (ADNr 16S ou divers gènes de ménage comme [...]) devient de plus en plus souvent une nécessité, car les caractères phénotypiques à notre disposition en nombre limité ne permettent souvent pas d'obtenir un diagnostic de certitude. C'est plus particulièrement le cas dans le groupe des bactéries anaérobies facultatives [...]  1, record 2, French, - s%C3%A9quen%C3%A7age%20de%20g%C3%A8ne

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 DEF

Sequence of amino acid residues along a polypeptide chain in a protein.  2, record 3, English, - primary%20structure

Record number: 3, Textual support number: 1 CONT

Today, the relative ease of gene sequencing is leading to an explosion in the derivation of protein primary structure by direct gene translation. This information is being stored in DNA databanks. The current problem with the design of enzymes is that we are still unable to predict reliably the three-dimensional structure adopted by a known primary structure(amino acid sequence)... Minor changes in primary structure can result in the formation of additional intramolecular intersubunit electrostatic or hydrophobic bonds. Even a small number of these bonds can drastically increase the stability of subunit enzymes against dissociative inactivation.  3, record 3, English, - primary%20structure

Record number: 3, Textual support number: 1 OBS

It completely determines the secondary, tertiary, and quaternary structures.  2, record 3, English, - primary%20structure

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 DEF

Dans une chaîne polypeptidique, arrangement séquentiel des acides aminés dont l'enchaînement est assuré par des liaisons peptidiques covalentes.  2, record 3, French, - structure%20primaire

Record number: 3, Textual support number: 1 CONT

La structure primaire de la molécule protéique [...] est la structure la plus importante et la plus spécifique : elle détermine les structures secondaire et tertiaire. [...] Les protéines thermostables, une fois déterminées leurs structures primaire et tertiaire, serviraient de modèles pour la construction d'enzymes qui pourraient alors être produites par génie génétique. Car si nous comprenions les principes qui donnent leur stabilité aux protéines, nous pourrions ne modifier que quelques résidus d'acides aminés de protéines connues pour les rendre stables.  2, record 3, French, - structure%20primaire

Record 3,  Textual support,  Spanish

Record number: 3, Textual support number: 1 DEF

Secuencia lineal de residuos que forman un polímero, como por ejemplo, ácidos nucleicos, polisacáridos o proteínas.  2, record 3, Spanish, - estructura%20primaria

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 CONT

What is Post-Genomics Biology? In this era of whole-genome sequencing, the questions are changing-the driving force is no longer to clone and sequence genes in the random fashion that was available before, but rather to use the wealth of information available from the sequencing projects to understand gene function and gene product interactions at the physiological level. Do homologous proteins have homologous functions in different organisms? How do we use information from a 'simple’ organism to focus research in more complex ones? What do all these genes do that have not been seen using traditional methods? How can we understand the different roles of members of gene families which are only now appearing as a result of the genome sequencing projects?  1, record 4, English, - post%2Dgenomics%20biology

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 CONT

Le gouvernement français s'apprête à lancer une action de grande envergure en génomique fonctionnelle et post-génomique.  1, record 4, French, - post%2Dg%C3%A9nomique

Record 4,  Textual support,  Spanish

Record 5,  Textual support,  English

Record number: 5, Textual support number: 1 OBS

Such as DNA gene sequencing and protein folding.  1, record 5, English, - biomolecular%20simulation

Record 5,  Textual support,  French

Record 5,  Textual support,  Spanish

Record 6,  Textual support,  English

Record number: 6, Textual support number: 1 DEF

Chromosome walking, one strategy for filling in gaps, involves hybridizing a primer known sequence to a clone from an unordered genomic library and synthezing a short complementary strand(called walking along a chromosome). The complementary strand is then sequenced and its end used as the next primer for further walking; in this way the adjacent, previously unknown region is identified and sequenced. Chromosome walking is also used to locate specific genes by sequencing the chromosomal segments between markers that flank the gene of interest.  1, record 6, English, - walking%20along%20a%20chromosome

Record 6,  Textual support,  French

Record number: 6, Textual support number: 1 DEF

Isolement séquentiel des clones dont les extrémités se chevauchent. Permet de progresser de proche en proche sur le DNA génomique à partir d'une séquence clonée initiale, dans un sens ou dans l'autre.  1, record 6, French, - marche%20sur%20le%20g%C3%A9nome

Record 6,  Textual support,  Spanish

Record 7,  Textual support,  English

Record number: 7, Textual support number: 1 CONT

Direct sequencing of exon 17 of the amyloid precursor protein(APP) gene led to the identification of 3 different types of APP717 pathogenic mutations associated with familial Alzheimer's disease(FAD).  3, record 7, English, - amyloid%20precursor%20protein

Record number: 7, Textual support number: 1 OBS

Term and context extracted from PASCAL data base.  1, record 7, English, - amyloid%20precursor%20protein

Record 7,  Textual support,  French

Record number: 7, Textual support number: 1 OBS

Équivalent trouvé dans une liste de descripteurs français d'un article tiré de la base de données PASCAL.  1, record 7, French, - prot%C3%A9ine%20pr%C3%A9curseur%20amylo%C3%AFde

Record 7,  Textual support,  Spanish