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GENE SUBSTITUTION [4 records]

Record 1 1997-06-18

English

Subject field(s)
  • Microbiology and Parasitology
CONT

A variety of approaches is being used to develop a vaccine. The most advanced are live oral vaccines developed by scientists at the US National Institutes of Health and Wistar Institute, in collaboration with US vaccine manufacturers. These are "re-assortant" vaccines-so-called because they are based on an animal strain of rotavirus(from a monkey or cow) that has been modified by the substitution of gene segments from human strains of the virus. These genes encode protective antigens from the outer shell of the virus. The vaccines include genes from the four serotypes of rotavirus most commonly found-all of which occur in children. They are produced in tissue culture.

French

Domaine(s)
  • Microbiologie et parasitologie
OBS

réassortir : Reconstituer un assortiment en complétant ou en remplaçant ce qui manque.

OBS

Proposition approuvée par un chercheur de l'Unité de vaccinologie du Centre hospitalier de l'Université Laval (CHUL) à Québec.

Spanish

Save record 1

Record 2 1992-01-27

English

Subject field(s)
  • Genetics
OBS

(...), the distinction between gene mutation in the individual and gene substitution in the population should be kept in mind; only the latter is directly related to molecular evolution.

French

Domaine(s)
  • Génétique
OBS

(...), il faut toujours garder à l'esprit la distinction entre mutation génique chez l'individu et substitution allélique dans la population: seule cette dernière concerne directement l'évolution moléculaire.

Spanish

Save record 2

Record 3 1980-09-01

English

Subject field(s)
  • Microbiology and Parasitology
OBS

The alpha and beta chains have essentially the same structure, are about the same length and show roughly the same rate of evolutionary amino acid substitution. They arose through gene duplication some 450 million years ago and became differentiated as they accumulated mutations independently.

French

Domaine(s)
  • Microbiologie et parasitologie
OBS

Les chaînes alpha et bêta ont approximativement la même structure, sont de longueur à peu près identique et présentent des taux de substitution d'acide aminé voisins. Elles se sont formées, il y a quelque 450 millions d'années, par duplication génique, puis se sont différenciées indépendamment par accumulation de mutations.

Spanish

Save record 3

Record 4 1980-09-01

English

Subject field(s)
  • Microbiology and Parasitology
OBS

The alpha and beta chains have essentially the same structure, are about the same length and show roughly the same rate of evolutionary amino acid substitution. They arose through gene duplication some 450 million years ago and became differentiated as they accumulated mutations independently.

French

Domaine(s)
  • Microbiologie et parasitologie
OBS

Les chaînes alpha et bêta ont approximativement la même structure, sont de longueur à peu près identique et présentent des taux de substitution d'acide aminé voisins. Elles se sont formées, il y a quelque 450 millions d'années, par duplication génique, puis se sont différenciées indépendamment par accumulation de mutations.

Spanish

Save record 4

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