TERMIUM Plus^®

Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 CONT

Subtle shifts in the ratio between pro-and antiapoptotic molecules after activation of corticosteroid receptors decide neuronal fate. Glucocorticoid receptor(GR) activation induces apoptosis of granule cells in the hippocampus. In contrast, neuroprotection is seen after mineralocorticoid receptor(MR) activation. To date there is no in vivo evidence for direct interactions between corticosteroids and any of the key regulatory molecules of programmed cell death.  1, record 1, English, - antiapoptotic

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 CONT

Les stratégies antiapoptotiques sont, bien entendu, au cœur de l'activité des grosses entreprises pharmaceutiques, car la rentabilité d'une nouvelle molécule de ce type, potentiellement applicable à toutes les maladies neurodégénératives et traumatiques (accident vasculaire, lésion spinale...), ne fait guère de doute.  1, record 1, French, - antiapoptotique

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 DEF

A very potent synthetic glucocorticoid. It is used in the treatment of conditions that respond to glucocorticoids, as anti-inflammatory agents.  2, record 2, English, - triamcinolone

Record number: 2, Textual support number: 1 OBS

Used especially in treating psoriasis and allergic skin and respiratory disorders.  3, record 2, English, - triamcinolone

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 DEF

Corticostéroïde de synthèse, ayant des propriétés anti-inflammatoires et anti-allergiques.  2, record 2, French, - triamcinolone

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 OBS

The main glucocorticoid secreted by the adrenal cortex. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.  2, record 3, English, - hydrocortisone

Record number: 3, Textual support number: 2 OBS

Chemical formula: C₂₁H₃₀O₅  3, record 3, English, - hydrocortisone

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 OBS

Formule chimique : C₂₁H₃₀O₅  2, record 3, French, - hydrocortisone

Record 3,  Textual support,  Spanish

Record number: 3, Textual support number: 1 OBS

Fórmula química: C₂₁H₃₀O₅  2, record 3, Spanish, - hidrocortisana

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 DEF

An anti-inflammatory glucocorticoid used in veterinary practice.  2, record 4, English, - flumethasone

Record number: 4, Textual support number: 1 OBS

Chemical formula: C₂₂H₂₈F₂O₅  3, record 4, English, - flumethasone

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 OBS

Formule chimique : C₂₂H₂₈F₂NO₅  2, record 4, French, - flum%C3%A9tasone

Record 4,  Textual support,  Spanish

Record 5,  Textual support,  English

Record number: 5, Textual support number: 1 OBS

A derivative of prednisolone with high glucocorticoid activity and low mineralocorticoid activity. Absorbed through the skin faster than fluocinocide, it is used topically in treatment of psoriasis but may cause marked adrenocortical suppression.  2, record 5, English, - clobetasol

Record number: 5, Textual support number: 2 OBS

Chemical formula: C₂₂H₂₈ClFO₄  3, record 5, English, - clobetasol

Record 5,  Textual support,  French

Record number: 5, Textual support number: 1 OBS

Formule chimique : C₂₂H₂₈ClFO₄  2, record 5, French, - clob%C3%A9tasol

Record 5,  Textual support,  Spanish

Record 6,  Textual support,  English

Record number: 6, Textual support number: 1 OBS

Cream-colored crystals... Glucocorticoid; anti-inflammatory(gastric ulcer).  3, record 6, English, - 3%C3%9F%2D%5B%283%2Dcarboxypropanoyl%29oxy%5D%2D11%2Doxoolean%2D12%2Den%2D30%2Doic%20acid

Record number: 6, Textual support number: 2 OBS

3ß-[(3-carboxypropanoyl)oxy]-11-oxoolean-12-en-30-oic acid: form recommended by the IUPAC (International Union of Pure and Applied Chemistry).  1, record 6, English, - 3%C3%9F%2D%5B%283%2Dcarboxypropanoyl%29oxy%5D%2D11%2Doxoolean%2D12%2Den%2D30%2Doic%20acid

Record number: 6, Textual support number: 3 OBS

Chemical formula: C₃₄H₅₀O₇  4, record 6, English, - 3%C3%9F%2D%5B%283%2Dcarboxypropanoyl%29oxy%5D%2D11%2Doxoolean%2D12%2Den%2D30%2Doic%20acid

Record 6,  Textual support,  French

Record number: 6, Textual support number: 1 OBS

acide 3ß-[(3-carboxypropanoyl)oxy]-11-oxooléan-12-én-30-oïque : forme recommandée par l'UICPA (Union internationale de chimie pure et appliquée).  1, record 6, French, - acide%203%C3%9F%2D%5B%283%2Dcarboxypropanoyl%29oxy%5D%2D11%2Doxool%C3%A9an%2D12%2D%C3%A9n%2D30%2Do%C3%AFque

Record number: 6, Textual support number: 2 OBS

Formule chimique : C₃₄H₅₀O₇  3, record 6, French, - acide%203%C3%9F%2D%5B%283%2Dcarboxypropanoyl%29oxy%5D%2D11%2Doxool%C3%A9an%2D12%2D%C3%A9n%2D30%2Do%C3%AFque

Record 6,  Textual support,  Spanish

Record number: 6, Textual support number: 1 OBS

Fórmula química: C₃₄H₅₀O₇  2, record 6, Spanish, - carbenoxonola

Record 7,  Textual support,  English

Record number: 7, Textual support number: 1 DEF

An adrenocortical insufficiency due to the destruction or dysfunction of the entire adrenal cortex [affecting] both glucocorticoid and mineralocorticoid function.  5, record 7, English, - Addison%27s%20disease

Record number: 7, Textual support number: 1 CONT

In 1855, Thomas Addison first described adrenal insufficiency, which was subsequently named after him. The basis of Addison disease has dramatically changed since its initial description. Originally, the disease usually resulted from an infection of the adrenal gland; the most common infection was tuberculosis, which is still the predominant cause of Addison disease in developing countries. Currently, in developed countries, Addison disease most commonly results from nonspecific autoimmune destruction of the adrenal gland.  3, record 7, English, - Addison%27s%20disease

Record number: 7, Textual support number: 1 OBS

Addison’s disease ... is characterized by a bronzelike pigmentation of the skin and mucous membranes, anemia, weakness, and low blood pressure.  2, record 7, English, - Addison%27s%20disease

Record 7,  Textual support,  French

Record number: 7, Textual support number: 1 CONT

La maladie d'Addison est une maladie rare due à une atteinte des glandes corticosurrénales conduisant à un déficit total en aldostérone et en cortisol. C'est un médecin anglais, Thomas Addison, qui décrivit ses premiers cas d'insuffisance surrénale lente par destruction bilatérale des surrénales. [...] Autrefois, la maladie était due surtout à la tuberculose. À l'heure actuelle, on souligne la fréquence des atteintes auto-immunes (les anticorps produits par le système immunitaire attaquent les glandes surrénales). [Elle se caractérise notamment par] une pigmentation brunâtre de la peau, des plis de flexions, des zones de frottement (d'où le nom de maladie bronzée) et des muqueuses.  4, record 7, French, - maladie%20d%27Addison

Record 7,  Textual support,  Spanish

Record number: 7, Textual support number: 1 DEF

[Enfermedad que] se caracteriza por la pigmentación bronceada de la piel, postración grave y anemia progresiva. Es debida a la hipofunción de las glándulas suprarrenales y termina generalmente por la muerte.  1, record 7, Spanish, - enfermedad%20de%20Addison

Record 8,  Textual support,  English

Record number: 8, Textual support number: 1 CONT

Downward in the biological hierarchy, explanation for these response differences could notionally be linked to syntoxic hormone(glucocorticoid) responses in which blood glucose increases under stress.  1, record 8, English, - syntoxic

Record 8,  Textual support,  French

Record number: 8, Textual support number: 1 DEF

Relatif à une substance permettant d'habituer l'organisme à un toxique.  1, record 8, French, - syntoxique

Record 8,  Textual support,  Spanish

Record 9,  Textual support,  English

Record number: 9, Textual support number: 1 DEF

A natural glucocorticoid that is metabolically convertible to cortisol.  2, record 9, English, - cortisone

Record number: 9, Textual support number: 1 OBS

The human adrenal cortex secretes only minute amounts of cortisone; most of the cortisone found in peripheral plasma is formed from cortisol by a reversible reaction. The synthetic hormone exerts its pharmaceutical effects through its metabolic conversion to cortisol.  2, record 9, English, - cortisone

Record 9,  Textual support,  French

Record number: 9, Textual support number: 1 DEF

Hormone sécrétée par la corticosurrénale, moins active que le cortisol.  2, record 9, French, - cortisone

Record number: 9, Textual support number: 1 OBS

Synthétisée, elle est utilisée comme médicament anti-inflammatoire, antiallergique, etc.)  2, record 9, French, - cortisone

Record 9,  Textual support,  Spanish

Record number: 9, Textual support number: 1 DEF

Glucocorticosteroide adrenal. In vivo a hidrocortisona, de eficaz acción antiinflamatoria.  2, record 9, Spanish, - cortisona

Record 10,  Textual support,  English

Record number: 10, Textual support number: 1 DEF

17, 21-Dihydroxypregna-1, 4-diene-3, 11, 20-trione. A synthetic steroid with glucocorticoid activity and pronounced anti-inflammatory action.  2, record 10, English, - prednisone

Record number: 10, Textual support number: 1 CONT

A trial of prednisone, a powerful corticosteroid, showed a trend to reduce fatigue and increased muscle strength ... The drug reduces the inflammation and also affects the immune system.  3, record 10, English, - prednisone

Record 10,  Textual support,  French

Record number: 10, Textual support number: 1 CONT

La prednisone est environ 5 fois plus puissante selon le poids que la cortisone concernant l'activité glucocorticoïde et anti-inflammatoire.  3, record 10, French, - prednisone

Record 10,  Textual support,  Spanish

Record 11,  Textual support,  English

Record number: 11, Textual support number: 1 DEF

The major natural glucocorticoid(q. v.) synthesized in the zona fasciculata of the adrenal cortex; it affects the metabolism of glucose, protein and fats and has appreciable mineralocorticoid activity. It also regulates the immune system and affects many other functions.  2, record 11, English, - cortisol

Record number: 11, Textual support number: 1 OBS

When used as a pharmaceutical, it is usually referred to as hydrocortisone. For therapeutic uses.  2, record 11, English, - cortisol

Record 11,  Textual support,  French

Record number: 11, Textual support number: 1 DEF

Hormone (17-hydroxycorticostérone) la plus active et la plus importante parmi les corticoïdes agissant sur le métabolisme des glucides, sécrétés par la corticosurrénale.  2, record 11, French, - cortisol

Record 11,  Textual support,  Spanish

Record 12,  Textual support,  English

Record number: 12, Textual support number: 1 CONT

Steroid hormones can be grouped in various classes according to a number of criteria. Based on their chemical structure they can belong to one of the classes(series) mentioned above(e. g. "a pregnane derivative "). If their site of production is considered to be more important, one can distinguish for example between "ovarian" or "vadrenal" steroids. If their biological function is essential, terms like a glucocorticoid or sex steroids can be used. Finally, classification can also be based on their molecular actions("an estrogen-receptor agonist"), or biochemical effects.  1, record 12, English, - pregnane%20derivative

Record 12,  Textual support,  French

Record number: 12, Textual support number: 1 CONT

[...] l'Europe dispose d'une grande richesse de progestatifs. Deux groupes sont utilisés dans le traitement hormonal substitutif (THS): (1) la progestérone naturelle et la rétroprogestérone (2) les dérivés pregnanes et norpregnanes.  1, record 12, French, - d%C3%A9riv%C3%A9%20pregnane

Record 12,  Textual support,  Spanish

Record 13,  Textual support,  English

Record number: 13, Textual support number: 1 DEF

A test for the integrity of the adrenal-pituitary feedback loop, in which small amounts of the potent glucocorticoid dexamethasone are given to suppress pituitary secretion of adrenocorticotropic hormone(ACTH).  2, record 13, English, - dexamethasone%20suppression%20test

Record 13,  Textual support,  French

Record number: 13, Textual support number: 1 DEF

Épreuve testant la sensibilité de l'axe hypophyso-surrénalien à l'action puissamment freinatrice de la dexaméthasone.  1, record 13, French, - %C3%A9preuve%20de%20freinage%20%C3%A0%20la%20dexam%C3%A9thasone

Record 13,  Textual support,  Spanish

Record 14,  Textual support,  English

Record number: 14, Textual support number: 1 CONT

Ibuprofen displays anti-inflammatory, analgesic and antipyretic activity in animal studies. It has no demonstrable glucocorticoid effect.  2, record 14, English, - ibuprofen

Record number: 14, Textual support number: 2 CONT

Arthritis is often treated with NSAIDs (nonsteroidal anti-inflammatory drugs), among which are aspirin and ibuprofen.  3, record 14, English, - ibuprofen

Record 14,  Textual support,  French

Record number: 14, Textual support number: 1 DEF

Dérivé de l'acide propionique doué d'une action anti-inflammatoire modérée mais nette, et d'un discret pouvoir analgésique. [...] Ses effets secondaires et ses contre-indications sont ceux des anti-inflammatoires non stéroïdiens [...]  2, record 14, French, - ibuprof%C3%A8ne

Record number: 14, Textual support number: 1 CONT

L'ibuprofène a exercé une activité anti-inflammatoire, analgésique et antipyrétique au cours d'études sur des animaux. Aucun effet glucocorticoïde n'a pu être démontré.  3, record 14, French, - ibuprof%C3%A8ne

Record 14,  Textual support,  Spanish

Record 15,  Textual support,  English

Record number: 15, Textual support number: 1 CONT

Abundant pseudocallus formation at the site of stress fractures is a hallmark of corticosteroid-induced osteoporosis.  1, record 15, English, - pseudocallus%20formation

Record number: 15, Textual support number: 1 OBS

Osteoporosis due to glucocorticoid excess should be considered when there is associated osteoporosis of the skull, fractures of the ribs and pelvic rami, and prominent partially mineralized callus at the site of fracture.  2, record 15, English, - pseudocallus%20formation

Record 15,  Textual support,  French

Record number: 15, Textual support number: 1 OBS

cal : Nom donné à la substance fibreuse néoformée, (cal primaire), apparaissant au sein d'un foyer de fracture et aboutissant à la consolidation par ossification (cal secondaire).  2, record 15, French, - pseudo%2Dcal

Record number: 15, Textual support number: 2 OBS

Ce tissu est appelé cal primaire (...) S'il n'y a pas de stimulation par la suite, ce cal régresse. Cette observation s'applique à la formation du tissu de granulation plutôt qu'à la formation d'un cal véritable. Les signaux émis par les sollicitations de l'os contrôlent la formation du cal.  3, record 15, French, - pseudo%2Dcal

Record 15,  Textual support,  Spanish