TERMIUM Plus^®

Record 1,  Textual support,  English

Record number: 1, Textual support number: 1 OBS

Trivial name for glutathione : hydrogen peroxide oxidoreductase.  2, record 1, English, - glutathione%20peroxidase

Record 1,  Textual support,  French

Record number: 1, Textual support number: 1 CONT

Le protocole d'épreuve d'effort sur tapis roulant (60 min à 21 m·min-1, pente de 12 %) a induit un stress oxydatif important, tel qu'indiqué par le glutathion musculaire. L'administration d'œstrogène a eu peu d'effet sur les taux de vitamine E, l'activité de la glutathion peroxydase et de la superoxyde dismutase ainsi que sur le glutathion tissulaire post-exercice.  1, record 1, French, - glutathion%20peroxydase

Record 1,  Textual support,  Spanish

Record 2,  Textual support,  English

Record number: 2, Textual support number: 1 CONT

The main biotransformation steps of fluxapyroxad in rats are hydroxylation at the biphenyl ring, N-demethylation at the pyrazole ring, loss of a fluorine atom at the biphenyl ring, and conjugation with glucuronic acid or with glutathione derivatives... [N : must be written in italics. ]  1, record 2, English, - pyrazole%20ring

Record number: 2, Textual support number: 1 PHR

N-demethylation at the pyrazole ring.  1, record 2, English, - pyrazole%20ring

Record 2,  Textual support,  French

Record number: 2, Textual support number: 1 CONT

Les RRT [résidus radioactifs totaux] dans les feuilles de pommier se chiffraient entre 2,603 et 14,733 ppm et entre 3,723 et 9,729 ppm, respectivement, pour le chlorantraniliprole radiomarqué sur le carbonyle du noyau benzamide et sur le carbonyle du noyau pyrazole.  2, record 2, French, - noyau%20pyrazole

Record number: 2, Textual support number: 1 PHR

N-déméthylation du noyau pyrazole. [N : s'écrit en italique.]  3, record 2, French, - noyau%20pyrazole

Record 2,  Textual support,  Spanish

Record 3,  Textual support,  English

Record number: 3, Textual support number: 1 CONT

Congeners with varying numbers of ortho, meta, and para chlorines were extensively degraded, indicating relative nonspecificity for the position of chlorine substitutions on the biphenyl ring.  2, record 3, English, - biphenyl%20ring

Record number: 3, Textual support number: 2 CONT

The main biotransformation steps of fluxapyroxad in rats are hydroxylation at the biphenyl ring, N-demethylation at the pyrazole ring, loss of a fluorine atom at the biphenyl ring, and conjugation with glucuronic acid or with glutathione derivatives... [N : must be written in italics. ]  1, record 3, English, - biphenyl%20ring

Record number: 3, Textual support number: 1 PHR

Hydroxylation, loss of a fluorine atom at the biphenyl ring.  1, record 3, English, - biphenyl%20ring

Record 3,  Textual support,  French

Record number: 3, Textual support number: 1 CONT

Le nombre et la localisation des atomes de chlore sur le noyau biphényle définissent un isomère ou congénère de PCB [polychlorures biphényles].  2, record 3, French, - noyau%20biph%C3%A9nyle

Record number: 3, Textual support number: 1 PHR

Hydroxylation, perte d'un atome de fluor du noyau biphényle.  3, record 3, French, - noyau%20biph%C3%A9nyle

Record 3,  Textual support,  Spanish

Record 4,  Textual support,  English

Record number: 4, Textual support number: 1 DEF

Peptide chain made up of a few amino acids.  2, record 4, English, - oligopeptide

Record number: 4, Textual support number: 1 CONT

Naturally occurring oligopeptides include the tripeptide glutathione and the pituitary hormones vasopressin and oxytocin, which are octapeptides.  3, record 4, English, - oligopeptide

Record 4,  Textual support,  French

Record number: 4, Textual support number: 1 DEF

Molécule formée par l'enchaînement de quelques acides aminés grâce à la liaison peptidique.  2, record 4, French, - oligopeptide

Record 4,  Textual support,  Spanish

Record number: 4, Textual support number: 1 DEF

Péptido compuesto de menos de 10 aminoácidos.  2, record 4, Spanish, - oligop%C3%A9ptido

Record 5,  Textual support,  English

Record number: 5, Textual support number: 1 CONT

A far-Western blot(also known as an overlay assay) is used to detect the interaction of a recombinant GST [glutathione S-transferase] fusion protein(produced and purified from bacteria) with a target protein on a membrane.  2, record 5, English, - far%2DWestern%20blot

Record 5,  Textual support,  French

Record number: 5, Textual support number: 1 CONT

L'utilisation de la technique de Far-Western, dans le but d'identifier les interactions protéine-protéine entre un virus et son vecteur, ont permis d'isoler deux protéines de thrips de 50 et 94 kDa [kiloDaltons] présentant des affinités particulières pour les glycoprotéines du TSWV [tomato spotted wilt virus].  2, record 5, French, - technique%20de%20far%2DWestern

Record 5,  Textual support,  Spanish

Record 6,  Textual support,  English

Record number: 6, Textual support number: 1 CONT

5-oxoprolinuria is a metabolic, disorder caused by an inborn error of glutathione metabolism. It is characterized by excretion of massive amounts of 5-oxoproline(pyroglutamic acid) in the urine, and abnormally high levels of this acid in the blood and cerebrospinal fluid. The disorder is caused by a deficiency of the enzyme glutathione synthetase. Functioning of the central nervous system is impaired. High acidity levels in the blood and body tissues(metabolic acidosis) usually occur.  1, record 6, English, - pyroglutamic%20acid

Record 6,  Textual support,  French

Record number: 6, Textual support number: 1 CONT

Acidémie pyroglutamique. Maladie métabolique héréditaire récessive autosomique caractérisée par l'accumulation et l'excrétion urinaire excessive d'acide pyroglutamique (5-oxoproline), due au défaut de l'Activité de la glutathionsynthétase. Elle entraîne une anémie hémolytique chronique et une acidose métabolique, cette dernière pouvant faire défaut.  1, record 6, French, - acide%20L%2Dpyroglutamique

Record 6,  Textual support,  Spanish

Record 7,  Textual support,  English

Record number: 7, Textual support number: 1 CONT

I am interested in studying reactions of glutathione with electrophiles, enzyme catalysts for these reactions, and the biological and chemical fates of the glutathione-electrophile conjugate products of these reactions. My colleagues and I have identified a novel glutathione-conjugate transport protein, RLIP76, which functions in intracellular signaling pathways and can also transport structurally unrelated amphiphilic chemotherapeutic agents. We are currently studying the role of this transporter in lung cancer cell drug-resistance and morphology.  2, record 7, English, - glutathione%20conjugate

Record number: 7, Textual support number: 2 CONT

The molecular basis of glutathione conjugate transport in plants.  3, record 7, English, - glutathione%20conjugate

Record number: 7, Textual support number: 3 CONT

Kinetic studies of aflatoxin B1-glutathione conjugate formation in liver and kidneys of adult and weanling rats.... Aflatoxin B1(AFB1)-glutathione(GSH) conjugation is the major pathway for the detoxification of aflatoxin metabolites. This reaction is catalysed by GSH S-transferase(GST) and play a major role in modulation of AFB1 adduct formation to nuclear DNA.  4, record 7, English, - glutathione%20conjugate

Record number: 7, Textual support number: 1 OBS

conjugation: 1. The act of joining together or the state of being conjugated. ... 3. (chemistry) The joining together of two compounds to produce another compound, such as the combination of a toxic product with some substance in the body to form a detoxified product, which is then eliminated.  5, record 7, English, - glutathione%20conjugate

Record 7,  Textual support,  French

Record number: 7, Textual support number: 1 OBS

La double réduction de Birch du naphtalène fournit un triène non conjugué bien qu'un composé conjugué soit plus stable.  2, record 7, French, - compos%C3%A9%20conjugu%C3%A9%20du%20gluthation

Record number: 7, Textual support number: 2 OBS

Il y a plusieurs définitions possibles d'un système conjugué. Nous utiliserons la suivante : on appelle système conjugué, un ensemble d'atomes ayant des orbitales atomiques pouvant se recouvrir latéralement et permettant de fortes interactions électroniques entre au moins trois atomes contigüs. Les systèmes conjugués ont une réactivité originale car la délocalisation entraîne une certaine ambiguïté dans la répartition électronique.  3, record 7, French, - compos%C3%A9%20conjugu%C3%A9%20du%20gluthation

Record 7,  Textual support,  Spanish

Record 8,  Textual support,  English

Record number: 8, Textual support number: 1 CONT

Phytochelatins(PCs) are intracellular metal ligands produced by plants, fungi and algae in response to increase of metals in their environment. They are small metal-binding polypeptides, enzymatically produced from glutathione to form amino acids sequences(g-Glu-Cys) n-Gly where n=2 to 11. They sequester metals inside the cells by binding them through thiol coordination and by this way, limit damage to metabolic processes in reducing the cytotoxic free metal ion.  2, record 8, English, - phytochelatin

Record number: 8, Textual support number: 2 CONT

Hope for the phytoextraction of mercury has been inspired by recent discoveries showing some plants produce specific peptides, termed phytochelatins, that bind and detoxify hazardous metals such as cadmium.  3, record 8, English, - phytochelatin

Record 8,  Textual support,  French

Record number: 8, Textual support number: 1 DEF

Peptide de faible poids moléculaire riche en cystéine.  2, record 8, French, - phytoch%C3%A9latine

Record number: 8, Textual support number: 1 OBS

[Ce peptide] se lie fortement à des ions métalliques tels que le Cadmium (Cd) et le Cuivre (Cu).  2, record 8, French, - phytoch%C3%A9latine

Record 8,  Textual support,  Spanish

Record 9,  Textual support,  English

Record number: 9, Textual support number: 1 CONT

The phenotypic manifestations that have been described in association with GS [glutathione synthetase deficiency] deficiency include hemolytic anemia(occurring in mild GS deficiency) and 5-oxoprolinuria(pyroglutamicaciduria) and variable degrees of secondary neurological involvement(occurring in systemic GS deficiency).  1, record 9, English, - 5%2Doxoprolinuria

Record 9,  Textual support,  French

Record number: 9, Textual support number: 1 DEF

Maladie métabolique héréditaire récessive autosomique caractérisée par l'accumulation et l'excrétion urinaire excessive d'acide pyroglutamique (5-oxoproline), due au défaut de l'activité de la glutathionsynthétase.  2, record 9, French, - 5%2Doxoprolinurie

Record number: 9, Textual support number: 1 CONT

Le déficit en 5-oxoprolinase est une maladie autosomique récessive très rare [...] Le diagnostic est établi par la présence de 5-oxoprolinurie et par la faible activité de la 5-oxoprolinase.  2, record 9, French, - 5%2Doxoprolinurie

Record number: 9, Textual support number: 1 OBS

Elle entraîne une anémie hémolytique chronique et une acidose métabolique, cette dernière pouvant faire défaut.  3, record 9, French, - 5%2Doxoprolinurie

Record 9,  Textual support,  Spanish

Record 10,  Textual support,  English

Record number: 10, Textual support number: 1 DEF

An enzyme of the transferase class that catalyzes the transfer of the g-glutamyl group from glutathione to an amino acid to form a glutamyl-amino acid and the dipeptide cysteinyl-glycine.  1, record 10, English, - gamma%2Dglutamyl%20transpeptidase

Record number: 10, Textual support number: 1 OBS

Deficiency of the enzyme, an autosomal recessive trait, results in g-glutamyl transpeptidase deficiency.  1, record 10, English, - gamma%2Dglutamyl%20transpeptidase

Record 10,  Textual support,  French

Record number: 10, Textual support number: 1 CONT

Les phosphatases alcalines (PA) la gammaglutamyl transpeptidase (GGT), la lactase déshydrogénase (LDH), l'aspartate aminotransférase (AST) ainsi que l'échographie sont actuellement les examens les plus facilement réalisables et les moins onéreux pour le diagnostic des métastases hépatiques.  1, record 10, French, - gammaglutamyl%20transpeptidase

Record 10,  Textual support,  Spanish

Record 11,  Textual support,  English

Record number: 11, Textual support number: 1 DEF

Conversion of an open-chain organic compound into one having a closed ring structure. [Definition standardized by ISO.]  3, record 11, English, - cyclization

Record number: 11, Textual support number: 1 CONT

M3 was the major metabolite in the liver, unchanged dimethenamid was the major radiocarbon in fat. Metabolism was via glutathione conjugation, reductive dechlorination, hydroxylation, and ring cyclization.  2, record 11, English, - cyclization

Record number: 11, Textual support number: 1 OBS

cyclization: term standardized by ISO.  4, record 11, English, - cyclization

Record 11,  Textual support,  French

Record number: 11, Textual support number: 1 DEF

Transformation d'un composé organique à chaîne ouverte en un autre à structure cyclique. [Définition normalisée par l'ISO.]  2, record 11, French, - cyclisation

Record number: 11, Textual support number: 1 OBS

cyclisation : terme normalisé par l'ISO.  3, record 11, French, - cyclisation

Record number: 11, Textual support number: 2 OBS

Voir aussi les fiches TERMIUM pour les termes suivants : «cycle», «noyau» et «structure cyclique» (en chimie).  4, record 11, French, - cyclisation

Record 11,  Textual support,  Spanish

Record 12,  Textual support,  English

Record number: 12, Textual support number: 1 CONT

No parent residue was detected in excreta, milk, or tissues. Terminal residues were derived from glutathione conjugation, demethylation and reductive dechlorination.  2, record 12, English, - terminal%20residue

Record number: 12, Textual support number: 2 CONT

Since none of the [alpha]-amino groups that are combined in peptide linkages can ionize in the pH zone 0 to 14, the acid-base behavior of peptides is contributed by the free [alpha]-amino group of the N-terminal residue, the free [alpha]-carboxyl group of the carboxy-terminal (abbreviated C-terminal) residue, and those R groups of the residues in intermediate positions which can ionize.  3, record 12, English, - terminal%20residue

Record number: 12, Textual support number: 1 OBS

See also "carboxy terminal" and "N terminal" in TERMIUM.  4, record 12, English, - terminal%20residue

Record 12,  Textual support,  French

Record number: 12, Textual support number: 1 CONT

Si l'on traite une protéine par l'hydrazine à 100 °C, toutes les liaisons peptidiques sont rompues, et tous les résidus sont transformés en hydrazides, sauf le résidu COOH-terminal (ou C-terminal) que l'on retrouve sous forme d'aminoacide libre facile à isoler et à identifier.  2, record 12, French, - r%C3%A9sidu%20terminal

Record number: 12, Textual support number: 1 OBS

Au pluriel : «résidus terminaux», sur le modèle de «acides aminés terminaux» relevé dans le contexte accompagnant la vedette «N-terminal» dans TERMIUM.  3, record 12, French, - r%C3%A9sidu%20terminal

Record 12,  Textual support,  Spanish

Record 13,  Textual support,  English

Record number: 13, Textual support number: 1 DEF

Phenomenon producing either a loss of chromosomal material or a structural modification without any change in the quantity of material and produced by a cause which is not known.  1, record 13, English, - spontaneous%20chromosomal%20breakage

Record number: 13, Textual support number: 1 CONT

Spontaneous chromosomal breakage has been found in six inherited diseases : ataxia telangiectasia, glutathione reductase deficiency, Kostmann's agranulocytosis and pernicious anemia.  1, record 13, English, - spontaneous%20chromosomal%20breakage

Record 13,  Textual support,  French

Record number: 13, Textual support number: 1 DEF

Phénomène provoquant soit une perte de matériel chromosomique, soit une modification de structure sans que la quantité de matériel soit changée, et se déclenchant sans cause décelable.  1, record 13, French, - cassure%20chromosomique%20spontan%C3%A9e

Record number: 13, Textual support number: 1 CONT

(Le syndrome de Bloom) Les anomalies chromosomiques font rentrer ces deux observations dans le cadre des "cassures chromosomiques spontanées" englobant, selon Schroeder et Kurt (1971), six maladies héréditaires : le syndrome de Bloom, l'anémie de Fanconi, l'ataxie télangiectasie, le déficit en glutathion peroxydase, l'agranulocytose de Kostmann et l'anémie pernicieuse.  1, record 13, French, - cassure%20chromosomique%20spontan%C3%A9e

Record 13,  Textual support,  Spanish