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GLYCOSAMINOGLYCAN [3 records]

Record 1 2004-05-12

English

Subject field(s)
  • Blood
  • Medication
DEF

A sulfated glycosaminoglycan of mixed polysaccharide nature varying in molecular weights and composed of polymers of alternating derivatives of D-glycosamine and L-iduronic acid or D-glucuronic acid.

OBS

It is released by mast cells and by basophils of the blood and is present in many tissues, especially the liver and lungs. Heparin is a mixture of active principles, some of which have potent anticoagulant properties that result from binding to and greatly enhancing the activity of antithrombin III and from inhibition of a number of coagulation factors, particularly activated factor X (factor Xa). Heparin also has lipotrophic properties, promoting transfer of fat from the blood to the fat depots by activation of lipoprotein lipase.

French

Domaine(s)
  • Sang
  • Médicaments
DEF

Polysaccharide hautement sulfaté produit par les granulocytes basophiles du sang circulant et leurs dérivés tissulaires les mastocytes. Utilisé en thérapeutique comme anticoagulant.

Spanish

Campo(s) temático(s)
  • Sangre
  • Medicamentos
DEF

Ácido orgánico presente en los tejidos de los mamíferos. Inhibe la coagulación de la sangre. Polvo amorfo, blanco, higroscópico, soluble en agua.

Save record 1

Record 2 2001-08-10

English

Subject field(s)
  • Chemical Elements and Compounds
  • Biochemistry
  • Animal Science
DEF

Glycosaminoglycan; a major component of cartilage and other connective tissue,... composed of polymers of the repeating disaccharide beta-(1, 4) D-glucoronic acid-beta(1, 3)-N-acetyl-D-galactosamine-6-sulfate.

CONT

... chondroitin 6-sulfate has been found to be more efficient than chondroitin 4-sulfate for inhibiting detrimental enzyme activity.

Key term(s)
  • chondroitin-6 sulphate

French

Domaine(s)
  • Éléments et composés chimiques
  • Biochimie
  • Zootechnie
CONT

Il existe deux isoformes de chondroïtine sulfate : la forme 4-sulfate et la forme 6-sulfate. Dans les cartilages de sujets jeunes, la forme 4-sulfate prédomine sur la forme 6-sulfate, alors que c'est l'inverse dans les cartilages de sujets âgés. Plus le taux de chondroïtine-4-sulfate est bas et celui de 6-sulfate est élevé au sein du cartilage articulaire, plus le métabolisme des protéoglycanes décline. Le ratio chondroïtine-6-sulfate sur chondroïtine-4-sulfate serait donc le reflet du degré de gravité de l'arthrose. [...] Des deux formes de chondroïtine sulfate, le chondroïtine-4-sulfate favorise surtout la synthèse de glucosamine par les chondrocytes, tandis que le chondroïtine-6-sulfate inhibe surtout l'activité de l'élastase.

Spanish

Save record 2

Record 3 2000-01-19

English

Subject field(s)
  • Nervous System
DEF

Any of the cytoplasmic inclusion bodies found in neurons of parts of the central nervous system in myoclonic epilepsy and consisting of a complex of glycoprotein and glycosaminoglycan.

French

Domaine(s)
  • Système nerveux

Spanish

Save record 3

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