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GP41 [7 records]
Record 1 - internal organization data 2011-09-28
Record 1, English
Record 1, Subject field(s)
- Biochemistry
- Microbiology and Parasitology
Record 1, Main entry term, English
- glycoprotein 120
1, record 1, English, glycoprotein%20120
correct
Record 1, Abbreviations, English
- gp120 1, record 1, English, gp120
correct
Record 1, Synonyms, English
Record 1, Textual support, English
Record number: 1, Textual support number: 1 DEF
A glycoprotein from HIV’s envelope that binds to the CD4 molecules on cells’ outside membrane. 2, record 1, English, - glycoprotein%20120
Record number: 1, Textual support number: 1 CONT
gp160, code for a glycoprotein that provides an outer coat for the HIV(human immunodeficiency virus). The outer coat, in turn, is composed of gp120, which protrudes from the virus surface, and gp41, which is embedded in the envelope coat. 2, record 1, English, - glycoprotein%20120
Record number: 1, Textual support number: 1 OBS
Free gp120 in the body may be toxic to cells on its own, causing CD4 cell depletion in the immune system through apoptosis and neurological damage leading to AIDS dementia complex. 2, record 1, English, - glycoprotein%20120
Record 1, French
Record 1, Domaine(s)
- Biochimie
- Microbiologie et parasitologie
Record 1, Main entry term, French
- glycoprotéine 120
1, record 1, French, glycoprot%C3%A9ine%20120
correct, feminine noun
Record 1, Abbreviations, French
- gp120 2, record 1, French, gp120
correct, feminine noun
Record 1, Synonyms, French
Record 1, Textual support, French
Record number: 1, Textual support number: 1 CONT
Le VIH est constitué d'un noyau central contenant le génome viral et des enzymes dont la principale est la transcriptase inverse; ce noyau est entouré d'une membrane lipidique externe exhibant plusieurs projections [spikes] contenant un antigène, la glycoprotéine 120, qui favorise l'adhésion du virus à la surface de la cellule exprimant le récepteur CD4. 3, record 1, French, - glycoprot%C3%A9ine%20120
Record 1, Spanish
Record 1, Campo(s) temático(s)
- Bioquímica
- Microbiología y parasitología
Record 1, Main entry term, Spanish
- glucoproteína 120
1, record 1, Spanish, glucoprote%C3%ADna%20120
correct, feminine noun
Record 1, Abbreviations, Spanish
- gp-120 1, record 1, Spanish, gp%2D120
correct, feminine noun
Record 1, Synonyms, Spanish
Record 1, Textual support, Spanish
Record number: 1, Textual support number: 1 DEF
Glucoproteína que se encuentra en las espículas del VIH [virus de la inmunodeficiencia humana] que le sirven para adherirse al receptor CD4 de la célula T4. 1, record 1, Spanish, - glucoprote%C3%ADna%20120
Record number: 1, Textual support number: 1 CONT
La gp-120 circula libremente en el organismo y como partícula independiente puede por sí misma ser tóxica para las células, causando la depleción del sistema inmune a través de la apoptosis y el daño neurológico que puede conducir al complejo de demencia por sida. 1, record 1, Spanish, - glucoprote%C3%ADna%20120
Record 2 - internal organization data 2011-06-10
Record 2, English
Record 2, Subject field(s)
- Microbiology and Parasitology
- Biotechnology
Record 2, Main entry term, English
- viral protein
1, record 2, English, viral%20protein
correct
Record 2, Abbreviations, English
Record 2, Synonyms, English
Record 2, Textual support, English
Record number: 2, Textual support number: 1 CONT
The human immunodeficiency virus (HIV) genome encodes at least seven groups of viral proteins. These groups of proteins include the three classes of polypeptides present in the majority of animal retroviruses: 1. structural, nonenvelope polypeptides encoded by the gag gene; 2. enzymes required for virion replication (reverse transcriptase/r) and for cleavage of viral precursor proteins (protease/pr), both encoded by the pol gene; 3. envelope polypeptides encoded by env gene. In addition, HIV’s possess genes that encode four sets of polypeptides not found in the majority of typical retroviruses. These include a transactivating regulator of RNA translation (tat), a cis-acting downregulator of RNA transcription (nef), a regulator that modulates the expression of structural proteins (rev), a protein that modulates viral infectivity (vif), and two proteins (vpr,vpu) whose functions are still unclear. [From source a]. 2, record 2, English, - viral%20protein
Record number: 2, Textual support number: 1 OBS
Both the core and envelope of HIV are composed of viral proteins. The core viral proteins include p24 and p18, and the envelope viral proteins include gp41 and gp120. 3, record 2, English, - viral%20protein
Record 2, French
Record 2, Domaine(s)
- Microbiologie et parasitologie
- Biotechnologie
Record 2, Main entry term, French
- protéine virale
1, record 2, French, prot%C3%A9ine%20virale
correct, feminine noun
Record 2, Abbreviations, French
Record 2, Synonyms, French
Record 2, Textual support, French
Record number: 2, Textual support number: 1 CONT
Protéines virales. Les protéines du V.I.H.-1, toutes antigéniques, c'est-à-dire capables d'induire la production d'anticorps, se répartissent en : 1) Des protéines associées à la nucléocapside. Ce sont des protéines structurales internes liées aux unités d'ARN et formant avec elle la nucléoïde. 2) Des protéines d'enveloppes chargées de sucres (glycoprotéines) 3) De nombreuses autres protéines identifiées récemment et dont le rôle commence à être connu. 2, record 2, French, - prot%C3%A9ine%20virale
Record 2, Spanish
Record 2, Campo(s) temático(s)
- Microbiología y parasitología
- Biotecnología
Record 2, Main entry term, Spanish
- proteína viral
1, record 2, Spanish, prote%C3%ADna%20viral
correct, feminine noun
Record 2, Abbreviations, Spanish
Record 2, Synonyms, Spanish
Record 2, Textual support, Spanish
Record 3 - internal organization data 2011-06-01
Record 3, English
Record 3, Subject field(s)
- Medication
Record 3, Main entry term, English
- castanospermine
1, record 3, English, castanospermine
correct
Record 3, Abbreviations, English
Record 3, Synonyms, English
Record 3, Textual support, English
Record number: 3, Textual support number: 1 DEF
A plant alkaloid that has anti-HIV activity in vitro. 2, record 3, English, - castanospermine
Record number: 3, Textual support number: 1 OBS
The antiviral mechanism appears to involve inhibition of glucosidase I, an enzyme that catalyzes glycosylation of the envelope proteins gpl20 and gp41. Glycosylation may be necessary for viral binding to the CD4 receptor. 1, record 3, English, - castanospermine
Record 3, French
Record 3, Domaine(s)
- Médicaments
Record 3, Main entry term, French
- castanospermine
1, record 3, French, castanospermine
correct, feminine noun
Record 3, Abbreviations, French
Record 3, Synonyms, French
Record 3, Textual support, French
Record number: 3, Textual support number: 1 CONT
Traitement à visée spécifique du VIH: analogues de nucléosides. La castanospermine inhibe la glycosylation et interfère spécifiquement avec la gp160 et la gp 120. 2, record 3, French, - castanospermine
Record 3, Spanish
Record 3, Textual support, Spanish
Record 4 - internal organization data 2005-05-04
Record 4, English
Record 4, Subject field(s)
- Microbiology and Parasitology
- Cytology
- Biochemistry
Record 4, Main entry term, English
- envelope gene
1, record 4, English, envelope%20gene
correct
Record 4, Abbreviations, English
Record 4, Synonyms, English
- env gene 1, record 4, English, env%20gene
correct
- env 1, record 4, English, env
correct
Record 4, Textual support, English
Record number: 4, Textual support number: 1 OBS
The HIV envelope gene encodes the major virion surface envelope glycoprotein gp160, which then is processed to form a transmembrane segment(gp41) and a glycosylated external segment(gp120) ;the vpr(r) gene, whose function is presently unknown. 1, record 4, English, - envelope%20gene
Record 4, French
Record 4, Domaine(s)
- Microbiologie et parasitologie
- Cytologie
- Biochimie
Record 4, Main entry term, French
- gène enveloppe
1, record 4, French, g%C3%A8ne%20enveloppe
correct, masculine noun, less frequent
Record 4, Abbreviations, French
- gène env 1, record 4, French, g%C3%A8ne%20env
correct, masculine noun
Record 4, Synonyms, French
Record 4, Textual support, French
Record number: 4, Textual support number: 1 CONT
Les gènes du V.I.H.-1 comportent les trois gènes structuraux fondamentaux des rétrovirus, présents à la fois dans les cellules infectées et dans les particules virales matures. Le gène gag (ce qui signifie gène de l'antigène de groupe) qui code pour les protéines de nucléotide; le gène pol (pour polymérase) qui détermine la synthèse de l'enzyme caractéristique des rétrovirus, la transcriptase inverse (ou reverse transcriptase); à son extrémité existe un petit gène qui code pour une protéase dont le rôle est de cliver les protéines produites par le gène gag; le gène env (pour enveloppe) qui permet la synthèse des glycoprotéines de l'enveloppe virale. 2, record 4, French, - g%C3%A8ne%20enveloppe
Record 4, Spanish
Record 4, Campo(s) temático(s)
- Microbiología y parasitología
- Citología
- Bioquímica
Record 4, Main entry term, Spanish
- gen env
1, record 4, Spanish, gen%20env
correct, masculine noun
Record 4, Abbreviations, Spanish
Record 4, Synonyms, Spanish
- env 1, record 4, Spanish, env
correct, masculine noun
Record 4, Textual support, Spanish
Record number: 4, Textual support number: 1 DEF
Gen responsable de la síntesis de los componentes de la envoltura de los retrovirus: gp160, gp120 y gp41. 1, record 4, Spanish, - gen%20env
Record 5 - internal organization data 2004-10-05
Record 5, English
Record 5, Subject field(s)
- Biochemistry
- Microbiology and Parasitology
Record 5, Main entry term, English
- glycoprotein 160
1, record 5, English, glycoprotein%20160
correct, less frequent
Record 5, Abbreviations, English
- gp160 1, record 5, English, gp160
correct
Record 5, Synonyms, English
Record 5, Textual support, English
Record number: 5, Textual support number: 1 DEF
A precursor of HIV envelope proteins gp41 and gp120. 1, record 5, English, - glycoprotein%20160
Record 5, French
Record 5, Domaine(s)
- Biochimie
- Microbiologie et parasitologie
Record 5, Main entry term, French
- glycoprotéine 160
1, record 5, French, glycoprot%C3%A9ine%20160
correct, feminine noun, less frequent
Record 5, Abbreviations, French
- gp160 2, record 5, French, gp160
correct, feminine noun
Record 5, Synonyms, French
Record 5, Textual support, French
Record number: 5, Textual support number: 1 OBS
La glycosylation d'une protéine de 90 kDa (produit par le gène env du VIH), aboutit à un précurseur de 160 kDa intracellulaire dont le clivage par une protéase cellulaire donne naissance à : une glycoprotéine de 110/120 kDa, d'où le sigle gp110/120, N-terminale la plus externe (EGP), correspondant aux spicules d'attachement; une seconde de PM [poids moléculaire] plus faible (41 kDA ou gp41), C-terminale, qui est transmembranaire et dotée d'une région hydrophobe qui assure son ancrage à la membrane cellulaire phospholipidique. 3, record 5, French, - glycoprot%C3%A9ine%20160
Record 5, Spanish
Record 5, Campo(s) temático(s)
- Bioquímica
- Microbiología y parasitología
Record 5, Main entry term, Spanish
- glicoproteína 160
1, record 5, Spanish, glicoprote%C3%ADna%20160
feminine noun
Record 5, Abbreviations, Spanish
- Gp-160
Record 5, Synonyms, Spanish
- glucoproteína 160 1, record 5, Spanish, glucoprote%C3%ADna%20160
feminine noun
Record 5, Textual support, Spanish
Record number: 5, Textual support number: 1 OBS
Glucoproteína viral precursora de las Gp 41 y Gp 120 de la envoltura viral. La Gp160 se puede producir sintéticamente para ser usada como vacuna terapéutica. Mejora la respuesta inmune al administrarse a personas con VIH. 1, record 5, Spanish, - glicoprote%C3%ADna%20160
Record 5, Key term(s)
- Gp160
- Gp 160
Record 6 - internal organization data 1996-10-31
Record 6, English
Record 6, Subject field(s)
- Microbiology and Parasitology
Record 6, Main entry term, English
- p17
1, record 6, English, p17
correct
Record 6, Abbreviations, English
Record 6, Synonyms, English
Record 6, Textual support, English
Record number: 6, Textual support number: 1 CONT
The coat of the HIV virion bears numerous viral proteins "spikes" that project into the external medium. Each spike probably consists of four molecules of a protein called gp120 on the outside and the same number of gp41 embedded in the membrane. These envelope proteins play a crucial role when HIV binds to, and enters target cells. Underneath the envelope is a layer of matrix protein called p17, which in turn surrounds the core, or capsid. Gp stands for glycoprotein-the proteins are linked to sugars-and the number refers to the mass of the protein, in thousands of daltons. [From source a]. 2, record 6, English, - p17
Record 6, French
Record 6, Domaine(s)
- Microbiologie et parasitologie
Record 6, Main entry term, French
- p17
1, record 6, French, p17
correct, feminine noun
Record 6, Abbreviations, French
Record 6, Synonyms, French
Record 6, Textual support, French
Record number: 6, Textual support number: 1 CONT
Le génome viral du VIH comprend 3 gènes principaux soit le gag, le pol et l'env. Les glycoprotéines 120 et gp41 sont codées par le gène env tandis que le gène gag code les protéines du noyau [core proteins] telles les p55, p40, p24,p17 et p7; le gène pol code les protéines p66 et p51 (transcriptase inverse), p11 (protéase), et p32 (intégrase). 1, record 6, French, - p17
Record 6, Spanish
Record 6, Textual support, Spanish
Record 7 - internal organization data 1996-10-31
Record 7, English
Record 7, Subject field(s)
- Biochemistry
- Microbiology and Parasitology
Record 7, Main entry term, English
- soluble gp160
1, record 7, English, soluble%20gp160
correct
Record 7, Abbreviations, English
Record 7, Synonyms, English
Record 7, Textual support, English
Record number: 7, Textual support number: 1 OBS
gp160 : code for a glycoprotein that provides an outer coat for the HIV(human immunodeficiency virus). The outer coat, in turn, is composed of gp120, which protrudes from the virus surface, and gp41, which is embedded in the envelope coat. 2, record 7, English, - soluble%20gp160
Record 7, French
Record 7, Domaine(s)
- Biochimie
- Microbiologie et parasitologie
Record 7, Main entry term, French
- gp160 soluble
1, record 7, French, gp160%20soluble
correct, masculine noun
Record 7, Abbreviations, French
Record 7, Synonyms, French
Record 7, Textual support, French
Record 7, Spanish
Record 7, Textual support, Spanish
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