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GRADING FRACTION [1 record]
Record 1 - internal organization data 2017-04-27
Record 1, English
Record 1, Subject field(s)
- Toxicology
- Visual Disorders
Record 1, Main entry term, English
- irritation score
1, record 1, English, irritation%20score
correct
Record 1, Abbreviations, English
Record 1, Synonyms, English
Record 1, Textual support, English
Record number: 1, Textual support number: 1 CONT
Response to Morpholine - Route: Eye - Species: Rabbit - Dose: 0.1 ml undiluted - Irritation score = 67.7/110. 2, record 1, English, - irritation%20score
Record number: 1, Textual support number: 1 OBS
Numerical scoring system developed by Friedenwald, Hughes and Herrmann for the evaluation of primary irritants using the rabbit's eye(for the toxicologic appraisal of a given compound). Table 6 : Scale of weighted scores for grading the severity of ocular lesions : I. Cornea : A. Opacity... B. Area involved.... Total maximum score=80. II. Iris :... Total possible maximum=10. III. Conjunctivae :... Total maximum=20. The maximum total score(110) is the sum of all scores obtained for the cornea, iris and conjunctivae. NB : A test score may result in a fraction [as shown in the above example 67. 7/110] because of the fact that it represents the average of all the animals in the test group. 3, record 1, English, - irritation%20score
Record number: 1, Textual support number: 2 OBS
The above context was taken from an article by Draize et. al. in the December 1984 issue of the Journal of Pharmacology and Experimental Therapeutics, which is the basis for the cited irritation score. This article along with supplementary explanations on this concept were given to us by Evan D. Riehl, M.D., Medical Consultant at E.I. Du Pont de Nemours and Company, Newark, Delaware, USA. 3, record 1, English, - irritation%20score
Record 1, French
Record 1, Domaine(s)
- Toxicologie
- Troubles de la vision
Record 1, Main entry term, French
- cote d'irritation
1, record 1, French, cote%20d%27irritation
proposal, feminine noun
Record 1, Abbreviations, French
Record 1, Synonyms, French
- note d'irritation 1, record 1, French, note%20d%27irritation
proposal, feminine noun
Record 1, Textual support, French
Record number: 1, Textual support number: 1 OBS
Représentation numérique d'une évaluation complexe de l'irritation qui résulte d'une exposition à un produit chimique donné à partir des réactions des différentes parties de l'œil d'un lapin soumis à un essai toxicologique. 2, record 1, French, - cote%20d%27irritation
Record 1, Spanish
Record 1, Textual support, Spanish
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